Efficacy of N. sativa-honey vs. clotrimazole for VVC

Linda Rider

On the other hand, the authors mentioned that that inappropriate use of around-the-counter (OTC) medications like clotrimazole brings about drug resistance, major to better prevalence of the an infection.

The review comprised 84 married, nonpregnant women of all ages, concerning the ages of 18 and 49, who have been referred for VVC to the Baharloo Medical center of Tehran College of Healthcare Sciences, in Iran, from August 2019 to February 2020.

People with good yeast cultures had been randomly divided into two major groups: N. sativa-honey vaginal product (the intervention team n = 42) and 1{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} clotrimazole vaginal cream (the control group n = 42).

A ratio of hydroalcoholic extract of 3{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} N. sativa and 30{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} honey ended up made use of to formulate the previous vaginal cream.

Scientific symptoms and symptoms and lab tests had been recorded at baseline and 6 by 10 days soon after remedy. Clients utilized an applicator (5 grams) of the selected product ahead of heading to the mattress for seven consecutive nights.

At the start out of the review, 100{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} of the contributors in both equally groups described discharge, redness and itching.

Following finishing treatment, secretion, redness, itching and fungal society substantially improved in the two teams (P < 0.001).

But itching and discharge were statistically better in the N. sativa-honey group than in the clotrimazole group.

Conversely, pruritus and secretion significantly improved in the clotrimazole group compared to the N. sativa-honey group.

Vaginal cultures of Candida became negative in 67.5{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} of patients in the intervention group and in 74.4{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} of patients in the control group.

The difference in outcomes between the two therapies may be due to the additional benefit of combining N. sativa and honey, according to the authors, who noted that “N. sativa seems to have a synergistic effect.”

Honey inhibits the growth of Candida, which might be attributed in part to honey’s low pH, the osmotic pressure of honey and honey’s production of hydrogen peroxide.

“Most of the biological and medicinal effects of N. sativa on the prevention of fungal growth and the effective antiinflammatory and analgesic may be due to the presence of thymoquinone,” wrote the authors.

There was no statistically significant difference between the two therapies for fungal culture results, satisfaction with the method of drug prescribed and satisfaction with the drug itself.

No study patient showed drug-specific side effects either.

“The results of this study show that the N. sativa-honey significantly improves the symptoms of VVC thus, the application of N. sativa-honey can be considered as a complementary therapy in the treatment of VVC,” wrote the authors. “The complementary medicine appears to be safe, effective, and tolerable.”

However, due to the high cost, the investigators did not employ chromium agar medium to identify the type of Candida species. Additional studies are also needed to demonstrate the safety and the mechanism of action for N. sativa-honey vaginal cream.


Korabi MNA, Mirmolaei ST, Tabarrai M, et al. Comparison between the efficacy of nigella sativa-honey and clotrimazole on vulvovaginal candidiasis: a randomized clinical trial. Evid-based Complement Altern Med. Published online October 14, 2022. doi:10.1155/2022/1739729

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