Geneology International

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  • Cannabis has same effect on adolescents and a

    Cannabis has same effect on adolescents and a

    The shorter-time period consequences of vaporised hashish do not differ concerning adolescents and grownups, though cannabidiol (CBD) does not dampen the outcomes of the drug, finds a new examine led by UCL and King’s College London scientists.

    For the experimental review printed in Addiction, the researchers measured how typical cannabis buyers of various ages responded to inhaling cannabis with differing ranges of CBD.

    The analyze participants incorporated 24 adolescents (16-17 yrs outdated) and 24 grownups (26-29 decades outdated), all of whom ended up now typical buyers of hashish (.5 to three days for every week, averaging 1.5 times of cannabis use for every week).

    In a scientific study facility (Invicro), the members inhaled three varieties of vaporised hashish underneath near professional medical supervision. On a few independent weeks, individuals ended up offered both a placebo, or a strain of cannabis large in delta-9-tetrahydocannabinol (THC, the most important psychoactive part, which normally predominates in each unlawful and lawful markets), or a significant-CBD and higher-THC version (consisting of the same level of THC, and also made up of CBD)*. There have been administered in doses equivalent to normal recreational use.

    The participants were requested to report how the drug was influencing them at frequent intervals, and done exams evaluating their verbal memory and the psychotic-like effects of the drug (these types of as delusions, cognitive disorganisation or paranoia).

    The scientists found all the expected effects of hashish in the THC and THC+CBD problems, between the participants’ responses: sensation large, emotion nervous, possessing delicate transient psychotic-like ordeals, and memory impairment.

    On the other hand, crucially there was no evidence that adolescents differed from older people in their responses to cannabis, when below the impact.

    Lead author, psychology lecturer Dr Will Garden, who performed the analyze at UCL prior to moving to King’s Higher education London, mentioned: “Immediately subsequent consumption, hashish can elicit psychotic-like effects, and impair verbal memory, and adolescents in our analyze who consistently smoke hashish have been just as vulnerable to this as the older people were. Adolescence is a critical developmental phase of lifetime, when persons are at an increased hazard of developing mental overall health troubles.

    “Regularly developing transient psychotic-like consequences and memory impairments through cannabis use is most likely to augment the hazard of psychological distress, specially in all those who are vulnerable to these harms. Even so, critically, our results also point out that 16- to 17-calendar year-outdated hashish people were not more sensitive to the acute harmful effects of cannabis than grown ups.”

    In recent decades, there has been increasing concern about the impact of hashish on younger people today, as well as hope that CBD may well protect against some hashish harms. A latest prolonged-time period, observational review by the similar authors located that adolescents are more susceptible to hashish dependancy, as opposed to adult end users, but they are not extra susceptible to depression and stress and anxiety.**

    Hashish has normal variation in CBD, which is a non-intoxicating constituent of the drug, as perfectly as the relative concentrations of THC, which is psychoactive and gets people substantial.

    CBD has fast grown as an over-the-counter wellness supplement in current yrs, and previously CBD in cannabis had been assumed to mitigate in opposition to some of the uncomfortable effects of THC.

    For the hottest examine, in tests the impression of differing CBD concentrations, the researchers uncovered that CBD levels did not impression the subjective feel of the drug, and it also did not influence memory impairment or psychotic-like results.

    The scientists say their examine does not deal with high-dose CBD’s opportunity professional medical positive aspects when administered by alone, but the results do forged question on well-liked solutions that these decrease doses of CBD discovered in cannabis may possibly safeguard against THC’s acute results on memory and psychotic-like experiences.

    Dr Garden explained: “Adding a average dose of vaporised CBD, about 25mg, to cannabis that is currently large in THC does not change the subjective encounter, nor does it shield from results these kinds of as paranoia or memory impairment. Even so, we have not investigated the very long-phrase outcomes of minimal-dose CBD nor the therapeutic outcomes of large-dose pharmaceutical CBD below.”

    Senior writer Professor Val Curran (UCL Clinical Psychopharmacology Device, UCL Psychology & Language Sciences) commented: “Cannabis is the world’s most frequently employed internationally managed drug. It is specifically well-known amongst adolescents, with over 15{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} of 15-12 months-olds in England and 28{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} of individuals in the US reporting utilization in the previous year. As cannabis rules are promptly modifying all around the world, it is vital that we recognize irrespective of whether the adolescent mind is more vulnerable, in order to notify laws and correct, proof-primarily based harm reduction messaging. Below, we have uncovered that adolescents are neither more resilient nor far more susceptible to the rapid effects of hashish.”

    The investigation fashioned aspect of the Professional medical Investigation Council-funded CannTeen study***, associated scientists at UCL, King’s School London, the College of Bathtub and Invicro llc, and been given total moral approval from the UCL Ethics Committee. As all participants had been around 16 yrs previous, all people consented as a lawful grownup. All individuals had been by now cannabis consumers and the analyze was finished securely with out issues, with medical experts current at all situations.

    The scientists say that strengths of this randomised, double-blind, placebo-controlled experiment are the restricted experimental controls and that individuals in the grownup and adolescent groups ended up meticulously matched on their natural cannabis use. The researchers warning that their study does not lose light-weight on prolonged-phrase impacts of cannabis.

     

    * For a 75kg particular person, the “THC” issue experienced 8mg of THC, and the “THC+CBD” situation experienced 8mg of THC + 24mg of CBD. This dose of THC displays roughly 1 quarter of a joint, and a average dose of CBD that was assumed may affect the drug’s consequences. The placebo consisted of a product or service making use of hashish as the starting material, but with all cannabinoids (which includes THC and CBD) taken out.

    ** UCL News, 2022: Adolescents additional vulnerable to cannabis habit but not other psychological well being challenges

    *** Far more about the CannTeen examine

    Strategy of Study

    Randomized controlled/scientific trial

    Topic of Analysis

    Men and women

    Report Title

    The acute outcomes of hashish with and with no cannabidiol in grown ups and adolescents: a randomised, double-blind, placebo-managed, crossover experiment

    Article Publication Date

    7-Feb-2023

  • 9 Science-Backed Benefits Beyond Its Calming Effect

    9 Science-Backed Benefits Beyond Its Calming Effect

    Tea With Chamomile

    Chamomile tea is a popular herbal tea made from the dried flowers of the Chamomile plant. It is known for its calming and relaxing properties, making it a popular choice for helping with sleep and reducing anxiety. Chamomile tea has a light, slightly sweet and floral flavor and is often enjoyed before bedtime. It is also believed to have a number of health benefits, including aiding in digestion, reducing inflammation, and helping with skin conditions. Chamomile tea is generally considered safe and can be consumed by most people, although those with allergies to plants in the daisy family may want to avoid it.

    Chamomile is widely known and used for its ability to soothe the nerves and calm the body. However, this flower boasts several other lesser-known but equally powerful health benefits. As a natural remedy, it can treat ailments beyond insomnia or nerves, such as PMS symptoms, inflammation, diarrhea, nausea, and gas. With over 100 bioactive substances contributing to chamomile’s benefits, it’s a rich source of antioxidants and even has antimicrobial qualities.

    What is Chamomile?

    Chamomile is a daisy-like flower native to Europe, Africa, Asia, and North America. Chamomile is known to have been used as medicine from as early as 500 BC. It was prescribed for fever in the medieval age and is used as a remedy for colic in babies to this day.[1] Chamomile flowers must be steeped instead of boiled to make tea, to preserve its antioxidants. You can also take chamomile powder in capsule form or drink a chamomile tincture. Chamomile tea is mild as opposed to bitter, with a slightly sweet undertone, a silky texture, and a floral aroma.

    Types of Chamomile

    There are different types of chamomile, including German chamomile, Roman chamomile, English chamomile, and Egyptian chamomile. German chamomile is the most common kind brewed as medicinal tea. German chamomile is more concentrated in the bioactive compounds of chamomile, and it boasts a smoother taste.

    9 Benefits of Chamomile

    There are many reasons to enjoy chamomile tea beyond its taste and soothing effect. Here are 9 things chamomile can do to transform human health, according to science:

    1. Huge Source of Antioxidants

    Chamomile flowers contain high levels of antioxidants, including flavonoids, phenols, and terpenoids.[2] Free radicals from the environment and natural metabolic processes can damage DNA when not balanced by antioxidants. Antioxidants neutralize free radicals and prevent this damage, which is known as oxidative stress–a precursor to many chronic diseases. The antioxidants in chamomile help keep your cells young, and they protect your heart, brain, and other vital organs against chronic diseases.

    2. Combats Diarrhea

    Chamomile was traditionally used as a natural remedy for diarrhea, and modern research seems to have confirmed its effectiveness. In a lab study, chamomile extract was found to stop diarrhea in rats through its antioxidant enzyme activities.[3] Meanwhile, a clinical trial on children with diarrhea found that chamomile extract improved symptoms.[4]

    3. Helps Fight Anxiety and Depression

    Chamomile has a mild sedative effect that can be helpful in alleviating anxiety and soothing the nerves in the face of stress. In a study on 57 participants with depression and anxiety, 220 mg of chamomile per day taken in capsule form decreased symptoms significantly better than a placebo in all participants.[5]

    4. Improves Sleep Quality

    The quality of your sleep includes how long it takes you to fall asleep (ideally less than 20 minutes), and how long you stay asleep (ideally one interruption per night at most). Stress and anxiety can cause trouble falling asleep or sleeping soundly. An antioxidant in chamomile known as apigenin binds to benzodiazepine receptors in your brain to produce tranquilizing effects.[6]

    In a 28-day study on insomnia patients, 270 mg of chamomile taken twice daily improved sleep quality and daytime functioning.[7] Even if you don’t suffer from insomnia, taking chamomile could potentially help you get more out of your night’s sleep.

    5. Reduces Inflammation

    According to research published in the International Journal of Molecular Medicine, chamomile binds to receptors that regulate your inflammatory response.[8] In addition to its anti-spasmodic qualities, chamomile’s anti-inflammatory action is part of how it soothes the gut. In traditional medicine, chamomile flowers were prepared in salves or ointments for the skin to treat inflammatory conditions like rashes and eczema.[6]

    Chronic inflammation in the body is linked to a wide range of diseases, from cancer to heart disease. Herbs like chamomile that lower inflammation can potentially lower your risk for these common diseases.

    6. Alleviates Menstrual Cramps

    Drinking chamomile can be helpful for menstruating women. According to a review of studies that examined the effects of chamomile on menstrual pain and bleeding, chamomile in daily doses ranging 250 to 500 mg per day effectively reduced pain and bleeding volume. In fact, chamomile was more effective in relieving pain than non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen.[9]

    Heavy menstrual bleeding can be caused by excess production of prostaglandins — hormone-like substances that control uterine contraction. Chamomile seems to work by balancing the body’s prostaglandin production to reduce heavy bleeding.

    7. Relieves Gas and Bloating

    A popular benefit of chamomile is its ability to relieve gas, flatulence, indigestion, and bloating when you’re in a pinch. A cup or two of chamomile tea can help ease most symptoms of gastrointestinal distress, which is why chamomile is often included in herbal remedy blends for irritable bowel syndrome.[10] Whether you get an occasional stomachache or you’re struggling with a gut-related illness, chamomile can probably help. It’s also used to relieve colic in babies.

    8. May Help Prevent Cancer

    The antioxidant in chamomile called apigenin serves the function in chamomile to protect the plant against ultraviolet radiation. As it turns out, this compound can also potentially help protect humans against melanoma. In fact, chamomile has shown wide-ranging anti-cancer actions in multiple types of cancers, including prostate, bone, lung, breast, and colon cancer.[11] While research has only been done in test tubes and petri dishes so far, it points to the possibility that the apigenin in chamomile could help prevent cancer in healthy individuals.

    9. Protects Metabolic Health

    Research shows that chamomile can lower high blood sugar in people with type 2 diabetes. In one study, three cups of chamomile tea per day were shown to improve blood sugar levels within eight weeks.[12] Drinking chamomile tea with meals could potentially help healthy individuals protect against blood sugar spikes that put you at risk of developing metabolic diseases like diabetes.

    Chamomile’s Many Benefits and Uses

    Chamomile tea is one of the most versatile natural remedies to keep at your home. Its smooth, floral taste makes it easy to enjoy on a daily basis, and doing so gives you long-term health benefits, including disease prevention. When you need help settling an anxious mind or getting to sleep when you’re stressed, chamomile can also help.

    References:

    1. abc.herbalgram.org/site/DocServer/CRCPRESSChamomile-Section_1.5978-1-4665-7759-6.pdf
    2. “Antioxidant and anticancer activities of chamomile (Matricaria recutita L.)” by Bayan Al-Dabbagh, Ismail A. Elhaty, Mohamed Elhaw, Chandraprabha Murali, Ameera Al Mansoori, Basma Awad and Amr Amin, 3 January 2019, BMC Research Notes.
      DOI: 10.1186/s13104-018-3960-y
    3. “Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats” by Hichem Sebai, Mohamed-Amine Jabri, Abdelaziz Souli, Kais Rtibi, Slimen Selmi, Olfa Tebourbi, Jamel El-Benn and MohsenSakly, 22 January 2014, Journal of Ethnopharmacology.
      DOI: 10.1016/j.jep.2014.01.015
    4. “Double-blind, randomized evaluation of clinical efficacy and tolerability of an apple pectin-chamomile extract in children with unspecific diarrhea” by Brigitta Becker, Ulrike Kuhn and Bettina Hardewig-Budny, 2006, Arzneimittelforschung Drug Research.
      DOI: 10.1055/s-0031-1296739
    5. “Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study” by Jay D Amsterdam, Justine Shults, Irene Soeller, Jun James Mao, Kenneth Rockwell and Andrew B Newberg, September 2012, Alternative Therapies in Health and Medicine.
      PMCID: PMC3600408
    6. “Chamomile: A herbal medicine of the past with a bright future (Review)” by Janmejai K. Srivastava, Eswar Shankar and Sanjay Gupta, 27 September 2010, Molecular Medicine Reports.
      DOI: 10.3892/mmr.2010.377
    7. “Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: A randomized placebo-controlled pilot study” by Suzanna M Zick, Benjamin D Wright, Ananda Sen and J Todd Arnedt, 22 September 2011, BMC Complementary and Alternative Medicine.
      DOI: 10.1186/1472-6882-11-78
    8. “Chamomile: An anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity” by Natarajan Bhaskaran, Sanjeev Shukla, Janmejai K. Srivastava and Sanjay Gupta, 1 December 2010, International Journal of Molecular Medicine.
      DOI: 10.3892/ijmm_00000545
    9. “The Effect of Chamomile on Pain and Menstrual Bleeding in Primary Dysmenorrhea: A Systematic Review” by Azin Niazi, MSc and Maryam Moradi, PhD, July 2021,
      International Journal of Community Based Nursing & Midwifery.
      DOI: 10.30476/ijcbnm.2021.87219.1417
    10. “Complementary and alternative medicines in irritable bowel syndrome: An integrative view” by Oliver Grundmann and Saunjoo L Yoon, 14 January 2014, World Journal of Gastroenterology.
      DOI: 10.3748/wjg.v20.i2.346
    11. “Apigenin in cancer therapy: anti-cancer effects and mechanisms of action” by Xiaohui Yan, Miao Qi, Pengfei Li, Yihong Zhan and Huanjie Shao, 5 October 2017, Cell & Bioscience.
      DOI: 10.1186/s13578-017-0179-x
    12. “Chamomile tea improves glycemic indices and antioxidants status in patients with type 2 diabetes mellitus” by Maryam Zemestani, Maryam Rafraf and Mohammad Asghari-Jafarabadi, 28 November 2015, Nutrition.
      DOI: 10.1016/j.nut.2015.07.011

  • The effect of prophylactic chemotherapy on treatment outcome of postmolar gestational trophoblastic neoplasia | BMC Women’s Health

    The effect of prophylactic chemotherapy on treatment outcome of postmolar gestational trophoblastic neoplasia | BMC Women’s Health

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  • Placebo effect: A cancer patient’s guide to alternative therapies

    Placebo effect: A cancer patient’s guide to alternative therapies

    They may well not essentially have scientific proof, but therapies ranging from forest bathing to exotic spices can make us come to feel greater, writes journalist and most cancers affected person Jeremy Rose.

    In the late 1980s, I developed a

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  • Omicron variant spreads to U.K., Germany, Italy as new travel bans take effect : Coronavirus Updates : NPR

    Omicron variant spreads to U.K., Germany, Italy as new travel bans take effect : Coronavirus Updates : NPR

    Vacationers wander around an electronic flight recognize board displaying canceled flights at O.R. Tambo Worldwide Airport in Johannesburg, South Africa, on Saturday. Numerous nations around the world have started travel bans in response to the omicron variant.

    Phill Magakoe/AFP by means of Getty Images


    cover caption

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    Phill Magakoe/AFP via Getty Visuals

    Tourists stroll near an electronic flight detect board exhibiting canceled flights at O.R. Tambo Intercontinental Airport in Johannesburg, South Africa, on Saturday. Many nations have begun vacation bans in reaction to the omicron variant.

    Phill Magakoe/AFP by means of Getty Images

    The omicron pressure of the coronavirus is cropping up across Europe, with cases detected in two people in the United Kingdom, two in Germany and at minimum a single in Italy, as the latest variant of concern spreads all over the globe.

    A number of nations, like the U.S., have initiated journey bans against South Africa — exactly where the speedily circulating new pressure was initially discovered on Nov. 24 — as very well as seven other southern African nations. More tests and self-isolation steps for travelers from these countries are also in location.

    The two persons arrived at Munich airport in Germany on Wednesday, according to a statement by the Bavarian Ministry of Overall health and Treatment. It states one more 50 folks who arrived from Cape Town on Friday are in quarantine.

    What to know about omicron, the new COVID variant

    At the very least two individuals in the United Kingdom have the omicron variant, Wellness Secretary Sajid Javid said Saturday. The folks are isolating at property.

    One circumstance was also recognized by wellness authorities in Italy, in accordance to Corriere della Sera, a foremost day-to-day newspaper.

    Circumstances have also been reported in Botswana, Belgium, Hong Kong and Israel throughout a rather short interval of time.

    In the U.S., the Centers for Ailment Handle and Prevention so considerably has not discovered any cases of the rapid-spreading pressure.

    President Biden has been briefed on the latest on the omicron variant, a White Property official stated Saturday.

    “At the identical time, senior health officers and the COVID response staff have been monitoring the most current updates on omicron and in normal touch with health officials around the planet,” the formal said.

    Stricter vacation restriction and testing steerage introduced

    The issue over the quick distribute of the variant has led to constraints on travel from quite a few nations in southern Africa. The Biden administration declared limited journey for non-U.S. citizens starting up Monday from South Africa, Botswana, Zimbabwe, Namibia, Lesotho, Eswatini, Mozambique and Malawi. The Condition Division also issued “do not travel” advisories for U.S. citizens.

    The European Union also introduced designs to halt vacation from South Africa and other southern African nations.

    In the U.K., Primary Minister Boris Johnson declared more necessities for travelers in a press convention Saturday.

    Peru has the world's highest COVID death rate. Here's why

    Any tourists getting into the nation will be essential to take a PCR examination by the conclusion of the next working day immediately after arrival, and be needed to self-isolate till they obtain a detrimental final result, Johnson stated.

    “We need to take qualified and proportionate steps now as a precaution as we find out far more,” Johnson reported. In aspect, he extra, the attempts are a way to obtain scientists additional time as they check out to discover additional about the variant.

    Johnson also thanked the experts in South Africa who recognized and shared information on the new variant “widely and right away.”

    More steps Johnson declared Saturday include at the time once more demanding face coverings in retailers and general public transportation, and requiring all contacts of everyone who exams positive for the omicron variant to isolate for 10 times no matter of vaccination standing.

    The mutations of the omicron variant are about, WHO claims

    The omicron variant is the initial new variant of problem given that the delta variant that swept as a result of the globe earlier this summer months, resulting in an uptick in bacterial infections and deaths, particularly among the the unvaccinated population. The delta strain was two times as infectious as the authentic COVID-19 virus.

    When there are a range of scientific tests underway to continue evaluating the omicron variant, the Earth Wellness Corporation claims the selection of mutations in this variant is “concerning” and that it could propose an “greater possibility of reinfection.”

    The WHO also suggests that existing COVID-19 tests are able of pinpointing this omicron variant, which is how authorities have been able to monitor how quickly the variant is spreading. But even more information and facts and experiments on the variant could get “times to weeks,” overall health officials from WHO mentioned.

    Specifically how rapid the variant is spreading and no matter whether the present-day vaccines readily available can stop an infection are nevertheless unclear. But Dr. Francis Collins, director of the National Institutes of Well being, advised NPR: “Allow me be clear, there is no knowledge at the present time to indicate that the existing vaccines would not do the job.”

    In the meantime, individuals ought to continue to just take steps to reduce their publicity to infection and lessen the spread of the virus, the WHO urges. This contains mask-carrying and having the vaccine when it is your switch to do so.

    Collins also suggests that people who are six months out from becoming absolutely vaccinated get their booster shot.