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Genetic Based Testing Creates New Department and New Discipline
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Dublin, Jan. 13, 2023 (GLOBE NEWSWIRE) — The “Global Clinical In Vitro Diagnostic Medical Laboratory Services Market: Strategy & Trends with Volume & Price Forecasts by Chemistry, Hematology, Microbiology, Pathology, Covid-19, and Molecular Dx by Country. Updated with Impact of COVID-19” report has been added to ResearchAndMarkets.com’s offering.

The Clinical Laboratory rose to the COVID challenge, but the end of the pandemic has created a new approach to diagnostics. Point of Care and Self Testing are threatening long term demand for clinical lab services but Molecular Diagnostics is driving runaway growth. Understand the opportunities and the threats in this comprehensive report.

The fundamentals are still here. Clinical laboratory testing is positioned to directly benefit from the explosion in biotechnology, especially genomics.

Exciting technical developments especially in the area of molecular diagnostics and pharmacogenomics hold the promise of a dynamic, growing and evolving world market that is moving out of the national and regional orientation and onto a global stage.

The report provides data that analysts and planners can use. Hundreds of pages of information including a complete list of Current United States Medicare Fee Payment Schedules to help sharpen your pricing. Make facilities planning decisions. Forecast demand for new testing regimes or technologies.

Make research investment decisions. Based on extensive primary and secondary research the testing volume data is broken down into price and volumes allowing researchers and investors to quickly create informed and reasonable forecasts of demand. Existing laboratories and hospitals can use the information directly to forecast and plan for clinical facilities growth.

A range of dynamic trends are pushing market growth and company valuations.

Trends like:

Key Topics Covered:

1 Market Guides
1.1 Clinical Laboratory Services – Strategic Situation Analysis and Covid -19 Impact
1.2 Guide for Executives, Marketing, Sales and Business Development Staff
1.3 Guide for Management Consultants and Investment Advisors

2 Introduction and Market Definition
2.1 The Growing Demand for Clinical Testing
2.2 Defining the Opportunity
2.2.1 Volumes
2.2.2 Prices
2.2.3 Revenue Market Size
2.3 Methods and Sources
2.3.1 Authors
2.3.2 Sources
2.4 Perspective: Healthcare, the IVD Industry, and the COVID-19 Pandemic
2.4.1 Global Healthcare Spending
2.4.2 Spending on Diagnostics
2.4.3 Important Role of Insurance for Diagnostics

3 Overview of a Dynamic Market
3.1 Players in a Dynamic Market
3.1.1 Academic Research Lab
3.1.2 Diagnostic Test Developer
3.1.3 Genomic Instrumentation Supplier
3.1.4 Pharmaceutical/Reagent Supplier
3.1.5 Independent Testing Lab
3.1.6 Public National/regional lab
3.1.7 Hospital lab
3.1.8 Physician Lab
3.1.9 Audit Body
3.1.10 Certification Body
3.2 Segmentation – Different Approaches
3.2.1 Traditional Market Segmentation
3.2.2 Laboratory Focus and Segmentation
3.3 Structure of Clinical Testing Industry
3.3.1 The Hospital Lab – Share of the Pie
3.3.2 Key Role for Economies of Scale
3.3.3 Physician Office Lab’s are Still Here
3.3.4 Physician’s and POCT – Reviving Patient Service in China
3.4 National and Regional Diversity

4 Trends Driving a Changing Market
4.1 Growth Is Pushed from Many Sides
4.1.1 Understanding the Impact of Aging Population
4.1.2 COVID Related Testing Growth
4.1.3 Point of Care Testing can increase demand
4.1.4 Alternative Medicine Creates Testing Opportunity
4.1.5 Esoteric Testing Moving Mainstream
4.1.6 Genetic Based Testing Creates New Department and New Discipline
4.2 Factors at Work to Shrink the Market
4.2.1 Lower Unit Costs
4.2.2 Economic or population contraction
4.2.3 Testing usage analysis curtailing growth
4.2.4 Wellness has a downside
4.2.5 Test Displacement Impacts Important
4.2.6 Point of Care Testing
4.3 Automation
4.3.1 Stranded LIMS Investment
4.3.2 Software as a Service
4.3.3 Physician Office and Access Systems
4.4 Environment and Evolution
4.5 Diagnostic Technology Development
4.5.1 Next Generation Sequencing Fuels a Revolution
4.5.2 Impact of NGS on pricing
4.5.3 POCT/Self Testing Disruptive Force
4.5.4 Pharmacogenomics Blurs Diagnosis and Treatment
4.5.5 CGES Testing, A Brave New World
4.5.6 Molecular Diagnostics Technologies at The Forefront of Growth
4.5.7 Biochips/Giant magneto resistance based assay

5 Laboratory, Molecular Diagnostics and Genomic Testing Recent Developments
5.1 Recent Developments – Importance and How to Use This Section
5.1.1 Importance of These Developments
5.1.2 How to Use This Section
5.2 Seegene to Enter Syndromic MDx Space
5.3 EKF Diagnostics Acquires Advanced Diagnostic Laboratory
5.4 Molecular Health, EDGC Ink Liquid Biopsy Partnership
5.5 ProPhase Labs Acquires Nebula Genomics for $14.6M
5.6 Karius Cell-Free DNA Method to Detect Infection Validated
5.7 South Korean Firm EDGC to Expand Into Liquid Biopsy Space With Cf DNA Platform
5.8 TruDiagnostic Receives CLIA Certification for Kentucky Laboratory
5.9 Enzo Biochem Q2 Revenues Up 62 Percent
5.10 Thermo Fisher Gets CE Mark for High-Throughput COVID-19 Assay
5.11 FDA Issues Alert – False Negatives due to SARS-CoV-2 Mutations
5.12 Will Labs Use Expanded Molecular Testing Capacities Post-COVID-19?
5.13 Chinese Infectious Dx Firm Vision Medicals Completes Series B Financing
5.14 Cooperative Aims to Expand Clinical, Commercial NGS Access
5.15 Emerging COVID-19 Sequencing Assays – An Alternative to Existing Diagnostics?
5.16 CDC Ranks Two More Microbes as ‘Urgent Threat’
5.17 ACLA Requests $5 billion to keep private labs going
5.18 Applied Biology to Launch New Laboratory for Hair and Skin Disorders
5.19 Quest Diagnostics Acquires Outreach Operations
5.20 Quest Diagnostics Buys Assets of Boston Clinical Laboratory Services
5.21 CLA Urges FDA to Halt Crackdown on PGx Testing
5.22 Quest Diagnostics Subsidiary Buys True Health Dx Assets
5.23 BioReference Laboratories selected by IPA Association

6 Profiles of Key Companies
6.1 Acibadem Labmed Laboratory
6.2 ACM Medical Laboratory
6.3 Adicon Clinical Laboratories
6.4 American Bio-Clinical Laboratories, Int’l
6.5 American Pathology Partners
6.6 ARUP Laboratories
6.7 Ascend Clinical
6.8 Assurance Scientific Laboratories
6.9 Aurora Diagnostics
6.10 Bio-Reference Laboratories
6.11 Bioscientia Institut fur Medizinische Diagnostik GmbH
6.12 BP Healthcare Group
6.13 Clinical Reference Laboratory
6.14 Clongen Laboratories
6.15 CompuNet Clinical Laboratories
6.16 Diagnosticos da America
6.17 DIAN Diagnostics Co., Ltd.
6.18 Enzo Biochem
6.19 Eone Laboratories
6.20 Eurofins Scientific
6.21 Exagen Diagnostics
6.22 Genzyme Corporation
6.23 Gribbles Pathology
6.24 Guangzhou Kingmed Diagnostics Group Co., Ltd.
6.25 Integrated Regional Laboratories
6.26 KDL Group
6.27 Laboratory Corporation of America
6.28 Lifelabs
6.29 Mayo Clinic Laboratories
6.30 Mid America Clinical Laboratories
6.31 MNG Labs
6.32 Myriad Genetics/Myriad RBM
6.33 NeoGenomics
6.34 OncoDNA
6.35 Pathology, Inc.
6.36 ProPhase Labs
6.37 Psychemedics Corporation
6.38 Quest Diagnostics
6.39 RDL Reference Laboratory
6.40 Sonic Healthcare
6.41 Spectra Laboratories
6.42 Sysmex Inostics
6.43 Unilabs

7 The Global Market for Clinical Laboratory Testing
7.1 Global Market Overview by Country
7.2 Global Market by Assay Type – Overview

8 Global Clinical Laboratory Diagnostic Markets – By Assay Type
8.1 Chemistry
8.2 Microbiology
8.3 Hematology
8.4 Anatomic Pathology
8.5 Covid-19
8.6 Molecular Diagnostics
9 Global Clinical Laboratory Diagnostic Markets – Price and Volume Charts
9.1 Chemistry Price and Volume
9.2 Microbiology Price and Volume
9.3 Hematology Price and Volume
9.4 Anatomic Pathology Price and Volume
9.5 Covid-19 Price and Volume
9.6 Molecular Diagnostics Price and Volume
10 The Future of the Clinical Laboratory

11 Appendices
11.1 United States Medicare System: 2021 Clinical Laboratory Fees Schedule

For more information about this report visit https://www.researchandmarkets.com/r/4stu7y

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January 14, 2023
People With Genetic Risk for Stroke Can Lower Risk via Healthy Lifestyle

Men and women who are genetically at bigger risk for stroke can decrease that chance by as significantly as 43{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} by adopting a healthier cardiovascular way of living, in accordance to new analysis led by UTHealth Houston, which was published today in the Journal of the American Coronary heart Association.

The review provided 11,568 grown ups from ages 45 to 64 who have been stroke-totally free at baseline and adopted for a median of 28 several years. The degrees of cardiovascular overall health have been centered on the American Heart Association’s Life’s Straightforward 7 recommendations, which contain halting cigarette smoking, ingesting greater, obtaining exercise, losing excess weight, running blood pressure, controlling cholesterol, and cutting down blood sugar. The life span threat of stroke was computed in accordance to what is termed a stroke polygenic chance score, with people today who experienced a lot more genetic possibility components joined to the chance of stroke scoring higher.

“Our study confirmed that modifying way of life danger factors, this kind of as controlling blood pressure, can offset a genetic threat of stroke,” said Myriam Fornage, PhD, senior creator and professor of molecular drugs and human genetics at the Institute of Molecular Drugs at UTHealth Houston. “We can use genetic data to ascertain who is at greater risk and stimulate them to undertake a balanced cardiovascular way of life, this kind of as adhering to the AHA’s Life’s Very simple 7, to lower that threat and are living a lengthier, more healthy everyday living.” Fornage is The Laurence and Johanna Favrot Distinguished Professor in Cardiology at McGovern Health care University at UTHealth Houston.

Just about every year, 795,000 people today in the U.S. go through a stroke, in accordance to the Facilities for Disease Control and Avoidance. That equates to an individual getting a stroke each and every 40 seconds, and another person dies from a stroke each 3.5 minutes. Stroke is a main cause of extended-term critical disability with stroke decreasing mobility in a lot more than half of stroke survivors age 65 and older. But stroke also takes place in young grownups – in 2014, 38{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} of people hospitalized for stroke were significantly less than 65 yrs outdated.

Folks in the study who scored the greatest for genetic danger of stroke and the poorest for cardiovascular wellbeing had the maximum lifetime threat of acquiring a stroke at 25{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}. No matter of the amount of genetic threat of stroke, people who experienced practiced optimal cardiovascular health and fitness reduced that possibility by 30{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} to 45{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}. That extra up to approximately 6 much more many years of everyday living totally free of stroke.

Total, folks with a very low adherence to Life’s Very simple 7 suffered the most stroke occasions (56.8{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}) while all those with a substantial adherence experienced 71 strokes (6.2{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}).

A limitation of the paper is the polygenic possibility score has not been validated broadly, so its medical utility is not best, specially for persons from numerous racial or ethnic backgrounds.

Reference: Thomas EA, Enduru N, Tin A, et al. Polygenic risk, midlife life’s uncomplicated 7, and life span threat of stroke. J. Am. Heart Assoc. ():e025703. doi: 10.1161/JAHA.122.025703

This post has been republished from the subsequent materials. Take note: substance may well have been edited for length and articles. For further more details, make sure you make contact with the cited source.

July 24, 2022
Healthy lifestyle may offset genetic risk of prostate cancer

Despite the fact that males could not be in a position to training their possibility of prostate cancer absent, lifestyle may possibly issue in the aggressiveness of the most cancers, researchers reported. Photo by qimono/Pixabay

Genes can put some adult males at heightened threat of prostate cancer, but a new study suggests they can undo substantially of that potential harm with a nutritious life-style.

Researchers observed that between guys at enhanced genetic chance of prostate most cancers, those people who maintained a balanced way of living were being much much less very likely to die of the sickness over just about 3 many years.

“Nutritious” intended they exercised consistently, refrained from smoking cigarettes, kept their excess weight down and favored fish around processed meat.

Adult men who met these aims had a 1.6{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} life time possibility of dying from prostate cancer. That compared with a 5.3{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} probability between their counterparts with harmful behaviors, the investigators found.

Having said that, nutritious routines did not show up to guard guys from building prostate most cancers in the initial spot, famous lead researcher Dr. Adam Kibel.

It is really probable they as a substitute decrease the possibility of aggressive prostate cancer, in accordance to Kibel, chief of urology at Brigham and Women’s Healthcare facility, in Boston.

Prostate cancer is extremely widespread: About a person in 8 guys will be diagnosed with the disorder in their life time, in accordance to the American Cancer Modern society (ACS). But the most cancers is typically slow-rising, and may in no way progress to the stage of threatening a man’s lifetime: Only one in every single 41 gentlemen really die of prostate cancer.

So whilst guys may possibly not be in a position to exercise their danger of the disorder absent, way of living may well matter in the aggressiveness of the cancer.

“A person way to glance at it is, an unhealthy way of living might throw gas on to the fireplace,” Kibel mentioned.

The research, revealed online a short while ago in the journal European Urology, concerned more than 12,000 adult men from two extensive-functioning investigate projects. All were being wellbeing professionals who, commencing in the 1980s, done periodic questionnaires on their wellness and way of living habits. They also gave blood samples, so their genetic info could be analyzed.

Prostate cancer has a massive genetic component, and about 200 gene variants have been connected to the hazard of producing the ailment. Kibel and his colleagues made use of that facts to assign every single participant a “polygenic threat rating” for their odds of creating prostate most cancers.

Every single male was also presented a healthier life style rating, earning 1 level for every of 6 components: preserving their weight beneath the being overweight cutoff routinely obtaining vigorous work out, like jogging not smoking cigarettes and frequently ingesting fatty fish (like salmon) eating tomato solutions and limiting processed meats. In specific, studies have tied individuals 3 diet program behaviors to a decreased possibility of prostate cancer or demise from the ailment.

Above 27 years, just in excess of 3,000 men made prostate most cancers, and 435 died from it. Genes produced a significant big difference: Gentlemen with genetic hazard scores in the top rated 25{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} were being about 4 times additional probable to die of the sickness, versus individuals in the base 25{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, the investigators located.

But for those identical men, life style also experienced a major effect. Individuals who trapped with at minimum 4 of the 6 healthful way of living components slice their odds of dying from prostate cancer by 45{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, as opposed to men who adhered to couple of or none.

Of all lifestyle habits, Kibel explained, exercising appeared most significant, adopted by sustaining a healthier pounds.

The results do not establish that all those nutritious patterns, per se, saved some men’s lives. But Dr. William Dahut, main scientific officer at the ACS, named the results “encouraging.”

“What is attention-grabbing is this indicates that a healthier way of living may well not reduce your hazard of creating prostate cancer, but may lower your risk of lethal prostate most cancers – which is significantly far more crucial,” said Dahut, who was not associated in the study.

In the real environment, gentlemen would not know their polygenic chance rating, but equally medical doctors stated that could improve in the coming yrs.

For now, males can get some perception of their genetic hazard based mostly on family history, although that is not the whole tale, Dahut stated. Possessing a father or brother with prostate most cancers much more than doubles a man’s threat of producing the disorder, according to the ACS.

Based mostly on the most recent conclusions, Kibel mentioned he suspects that a balanced way of life would help reduce the surplus threat linked to family members heritage.

There was no proof that way of living adjusted the chance of deadly prostate most cancers among the adult males at reduce genetic threat. That, Kibel reported, may well be since several of all those males died of the ailment – producing it really hard for any way of life measure to present an influence.

However, there are a great deal of factors further than prostate most cancers for guys to adopt healthful behaviors, both of those physicians said.

“Persons are normally happier when they are in fantastic actual physical shape,” Kibel famous.

He also inspired adult males to study about their household health care record. While women of all ages normally have a excellent perception of that, Kibel stated, he has identified that male individuals typically do not know if any family have experienced prostate most cancers.

Extra facts

The American Most cancers Society has more on prostate cancer.

Copyright © 2022 HealthDay. All rights reserved.

July 13, 2022
Dementia: 7 things to do to avoid the condition even if you have high genetic risk

A analyze of people today in the US implies those at significant genetic chance of dementia are less possible to develop the issue if they increase their lives in seven methods

Wellness

25 May perhaps 2022

By Jason Arunn Murugesu

A healthier life-style can assistance reduce the odds of acquiring dementia

Portra ehf./Getty Images

Individuals with a significant genetic danger for dementia can minimize the likelihood of establishing the condition by living a much healthier way of life, a review in the US suggests.

Adrienne Tin at Johns Hopkins University in Maryland and her colleagues applied facts from additional than 11,000 men and women in the US collected in between 1987 to 2019. The contributors experienced an common age of 54 at the commence of the study and were followed, on typical, for 26 a long time. Of these individuals, 8823 were being of primarily European descent and 2738 had been of mainly African descent.

The scientists devised a score for each and every participant centered on seven wellness things. These are: to cease smoking, try to eat a nutritious diet regime, manage a healthful excess weight, remain bodily active, and to management blood sugar levels, cholesterol amounts and blood stress. The team combined these elements into a solitary rating on a 14-place scale, with remaining the minimum wholesome and 14 the healthiest.

These elements are promoted by the American Heart Association as a suggests to retain excellent cardiovascular overall health and are recognized as “Life’s Easy 7”. Earlier scientific studies have demonstrated that enhancing your wellbeing in any of these locations can also decrease the chance of establishing dementia, states Tin.

In this research, the researchers preferred to see if this was continue to accurate for all those who are most at chance of establishing dementia due to their genetics.

The crew utilized genome-huge affiliation experiments to evaluate every single person’s genetic hazard for acquiring dementia, and then utilized the data to split the participants into groups based mostly on how superior their threat was. Individuals in the greatest chance group were being 1.5 to 2.7 occasions as possible to develop the disorder as people in the cheapest hazard team.

The scientists found that men and women of generally European descent in the maximum genetic possibility team could cut down the chance of creating dementia by 8 for every cent for every point by which they amplified their healthful life-style rating on the 14-issue scale.

They also saw similar results for people today of principally African descent, but thanks to the scaled-down sample sizing the researchers can not be as specific about their conclusions, says Tin. Overall, persons of primarily African descent who scored in between 9 and 14 in the way of living assessment experienced a 17 for every cent reduce possibility of dementia than people who scored amongst and 6, the crew observed.

In the timespan researched, 2234 of the members made dementia. “There had been no important distinctions in our conclusions among African and European ancestry,” Tin suggests.

“These conclusions show that it is particularly advantageous to preserve [these healthy habits] early in lifestyle, since our research finds that a larger Life’s Uncomplicated 7 rating in midlife is involved with reduced possibility for dementia,” she states.

She suggests the next move is to establish what social aspects may possibly avoid individuals from producing their lifestyles more healthy.

“These final results are pretty promising,” says Claudia Cooper at University University London. “They show that though none of us can know for selected our starting off hazard for developing dementia, we can all acquire measures to lower it.”

Rosa Sancho at the charity Alzheimer’s Investigation Uk states the outcomes are excellent news, but notes that due to the fact the way of life score was taken at the begin of the research, it is unclear regardless of whether a participant’s healthful practices lasted for the rest of the analyze.

“Ideally, long term experiments really should also include things like frequently monitoring wellness behavior in the participants to evaluate very long-term consequences of a nutritious life style,” she claims.

Journal reference: Neurology, DOI: 10.1212/WNL.0000000000200520

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May 29, 2022
A healthy lifestyle helps to prevent gestational diabetes in those at highest genetic risk — ScienceDaily

Researchers have designed a genetic-threat score for pinpointing individuals who would reward the most from life-style counselling to prevent gestational and postpartum diabetic issues.

Gestational diabetes is the most popular overall health-similar challenge for the duration of being pregnant. Right now, it is diagnosed in just about every fifth expectant mom in Finland. Gestational diabetes has a sizeable impression on the well being of both the mother and the baby, each throughout being pregnant and just after shipping and delivery.

A analyze executed at the College of Helsinki investigated the consequences of way of life intervention on the avoidance of gestational diabetes in ladies at high danger of acquiring gestational diabetes. In the Finnish Gestational Diabetes Avoidance Review (RADIEL), the review subjects obtained intensified actual physical physical exercise and dietary counselling for the duration of being pregnant and for the very first year next shipping.

In this analyze, a polygenic risk rating (PRS) describing the genetic possibility of diabetes was calculated applying gene variants acknowledged to enhance the hazard of variety 2 diabetic issues. The possibility score for form 2 diabetes was linked with elevated glucose concentrations in mid- and late being pregnant as well as just one calendar year immediately after delivery.

“Gestational diabetic issues as well as prediabetes and diabetic issues a person calendar year following delivery ended up also more prevalent among the people with larger scores,” claims Emilia Huvinen, specialist in obstetrics and gynaecology.

Qualified steps create much better final results

The study identified that genetic hazard also impacted the hyperlink in between way of living counselling and gestational diabetic issues as effectively as diabetic issues.

“Based mostly on our research, intensified life style interventions benefitted only ladies at best genetic possibility of creating kind 2 diabetic issues,” Huvinen confirms.

In accordance to her, the outcomes are considerable and even globally distinctive.

“Our examine gives a single probable rationalization for the contradictory benefits of earlier studies investigating the prevention of gestational diabetes until now ,” Huvinen describes.

In accordance to the researchers, genetic-risk scoring would make it feasible to recognize the expectant mothers most at chance as perfectly as to immediate resources and the most productive preventive steps specially at them. This would be of terrific value in conditions of each constrained societal resources and the well being of these mothers and their children.

“At the very same time, it can be crucial to realise that, in the case of diabetes, our genetic qualifications does not establish our future. With the aid of a nutritious way of life, you can reverse the effect of a substantial genetic diabetic issues risk,” Huvinen claims, offering encouragement.

Story Resource:

Materials offered by University of Helsinki. Take note: Information might be edited for fashion and length.

May 9, 2022