Geneology International

Tag: Preliminary

  • CBD and sleep: Promising but preliminary

    CBD and sleep: Promising but preliminary

    Based on who you talk to, cannabidiol (CBD) is possibly a wonder remedy or a placebo, a anxiety reliever, mood booster, suffering killer, or irritation fighter. For troubled sleepers, however, it’s a doable reprieve as investigate, though confined, gains steam. “Currently, there is not more than enough exploration on CBD’s performance with snooze problems, but preliminary scientific studies are suggesting there is some link,” claims Laura Fuentes, main officer of science and innovation at Eco-friendly Streets (Deerfield Beach front, FL), in particular as anecdotal proof indicates that CBD may well build a sense of quiet, and “a tranquil intellect and peaceful physique make a much better night’s rest,” she claims.

    Even though researchers do not know the specific mechanism of action for CBD as it relates to sleep, the ingredient’s consequences on the endocannabinoid technique (ECS) could be a jumping off position, as the ECS is identified to modulate circadian rhythms and is involved in the regulation of slumber-wake cycles—and CBD is a modulator of the ECS.1

    “To the extent that suffering or panic interferes with snooze, CBD may possibly facilitate rest by lowering discomfort or anxiety—this would be an indirect system,” adds Jamie Corroon, ND, MPH, healthcare advisor at CV Sciences (San Diego, CA, maker of PlusCBD) and founder and health-related director at the Heart for Professional medical Hashish Instruction. In fact, exploration reveals that blocking CB1 receptors in the ECS (as CBD does) can induce neurochemical variations identical to these triggered by antidepressants.2 “The proof in support of CBD as a sleep help is combined and reasonably minimal,” Corroon admits. “To be honest, this is a lot more a reflection of federal regulation associated to looking into cannabis and FDA’s latest placement on CBD as a nutritional component, than a reflection of interest or efficacy.”

    Early Conclusions

    Research linking CBD with a far more restful night’s rest is nonetheless underway and pretty substantially in its infancy even so, some conclusions do stage to the ingredient’s probable ability to enable involuntary evening owls.

    “As with numerous novel compounds which are publicly available, the proof starts off with anecdotes,” claims Corroon, and cross-sectional experiments have verified that not only do quite a few individuals use CBD for rest (roughly 42.5{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} of CBD buyers, in accordance to a person review3), but they also report efficacy. A 2019 randomized managed demo funded by CV Sciences described improvements in slumber high quality (+22.{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, p=.009) and snooze quantity (21.3{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, p=.02) soon after six weeks of everyday supplementation with 60 mg of PlusCBD Added Energy Hemp Extract Oil (15 mg hemp-derived CBD).4 Researchers in this review also found that hemp supplementation improved steps of perceived strain reaction and daily life pleasure.

    That explained, significantly more investigation is necessary, and models operating in this area will have to remain aware of that. “Companies need to have to keep an open up brain about the science relevant to CBD as it is in continuous flux,” claims Corroon. “Most importantly, sleep-connected promises for their CBD-that contains products and solutions must be extremely conservative, if not prevented completely.”

    Put together Cannabinoids

    Scientists analyzing CBD’s effect on slumber are turning their consideration to how it can do the job in tandem with other cannabinoids. “Recently, there has been a large amount of converse about cannabinol’s (CBN) advertising of slumber,” suggests Fuentes. “It is believed that given that CBN arrives from the degradation of tetrahydrocannabinol (THC), this could describe its rest-inducing possible.”

    Fuentes says there is home for investigation to identify whether or not combining CBD with CBN can produce a improved night’s sleep, as the clinical evidence is at the moment lacking. In point, one recent evaluation found that medical and preclinical study investigating the results of CBN is dated and restricted, with most human research developing in the 1970s and 1980s, and those people that particularly deal with the results linked with rest very uncommon. In the long run, researchers concluded there is “insufficient published proof to aid snooze-associated claims” for CBN.5 Once again, they termed for randomized managed trials to substantiate promises by polysomnography or validated snooze questionnaires.

    “Other cannabinoids may well be additional powerful [than CBD] at advertising rest,” agrees Corroon, “but it is not very clear at this issue.” Compounds like delta-8 and delta-9 THC do have sedation properties, he says, but they also have intoxicating houses, which can be a detriment for many individuals (CBD does not have these intoxicating properties). And, as Corroon points out, a comparison analyze investigating person cannabinoids for sleep has not still been printed. “A mixture may well verify to be most productive,” he says, “but the evidence is much too preliminary to draw organization conclusions.”

    References

    1. Corroon J et al. “The endocannabinoid method and its modulation by cannabidiol (CBD).” Alternate Therapies in Wellbeing and Drugs, vol. 25, s2 (June 2019): 6-14
    2. Witkin JM et al. “A part for cannabinoid CB1 receptors in mood and anxiousness disorders.” Behavioural Pharmacology, vol. 16, no. 5-6 (September 2005): 315-331
    3. Moltke J et al. “Factors for cannabidiol use: A cross-sectional examine of CBD users, focusing on self-perceived tension, panic, and slumber difficulties.” Journal of Cannabis Exploration, vol. 3, no. 1 (February 18, 2021): 5
    4. Lopez HL et al. “Effects of hemp extract on markers of wellness, pressure resilience, recovery and clinical biomarkers of basic safety in over weight, but in any other case wholesome topics.” Journal of Dietary Health supplements, vol. 17, no. 5 (2020): 561-586
    5. Corroon J. “Cannabinol and snooze: Separating fact from fiction.” Hashish and Cannabinoid Analysis, vol. 6, no. 5 (Oct 2021): 366-371
  • A Preliminary Report on Herbal Medicine Use Among Patients Hospitalize

    A Preliminary Report on Herbal Medicine Use Among Patients Hospitalize

    Introduction

    Globally, herbal medicines use has been reported as a common practice both in the prevention and treatment of diseases.1–3 This is especially common with diseases with high mortality, morbidity or those without conventional therapy that cure the disease. Previous studies in Uganda report that more than 60{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} of the population depended on traditional medicine before the coronavirus disease (COVID-19) pandemic.4 Due to the high mortality associated with the second wave of COVID-19, this practice is likely to have increased.

    Many factors have been identified as drivers of herbal medicine use. In many parts of the world, users have reported that herbal remedies are safe, effective, and are cheap.1,5 In Uganda, easy access, and cultural familiarity as well as the higher number of traditional health practitioners compared to health-care professionals are some of the common factors influencing this practice.4,6 A recent study in Uganda reported that media has increased the use of herbal medicines in the treatment and prevention of COVID-19.7 However, there is limited information concerning the level of herbal medicine use among hospitalized COVID-19 patients and the reasons why they resort to this practice even with the existence of conventional supportive treatment and vaccines.

    Although some studies have reported the role of combining herbal remedies with westernized medicine in the treatment of COVID-19,8 the side effects of these remedies are not well studied. This is in addition to the wide variation in the types of herbal medicines on the market which may wrongly influence their use. Various studies have documented harmful consequences of herbal remedies including hepatotoxicity and allergies, which may be worsened by confounders such as self-medication.1,9 The continued use of herbal medicines without question may lead to long-term health consequences for both the individual and the government.

    The Uganda National Drug Policy and Authority Statute (1993) gives the National Drug Authority (NDA) a mandate to regulate herbal medicine use including approving of all manufacturers. During the pandemic, several manufacturers have hit the market with herbal medicine products, but only a few of these are approved by the NDA and little has been done to regulate their practice.10 This study, therefore, aimed to determine the prevalence of and factors associated with herbal medicine use among hospitalized patients at the two large COVID-19 treatment units in Uganda.

    Methods

    Study Design and Setting

    An observational, cross-sectional study was conducted between July and August 2021 in two large CTUs in Kampala, Uganda, namely, Mulago National Referral Hospital CTU and Namboole Stadium CTU. These are the main referral CTUs in the country with bed capacities of over 30,000 beds catering for a diverse range of patients from all over the country. The CTUs run daily, seeing both patients referred from other health facilities across the country as well as patients who are being followed up routinely.

    Study Population

    We approached all patients hospitalized with COVID-19 in the two-largest CTUs in the country. Eligible participants were those confirmed to have COVID-19 and aged 18 years and above. Respondents with a known history of impaired mental capacity to provide coherent and reliable information, critically ill in the absence of a reliable caretaker were excluded.

    Sample Size Calculation

    The sample size was calculated using the Kish Leslie formula for cross-sectional studies where the estimated sample size at 95{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} confidence interval was 384 participants. To cater for non-response associated with critically ill, unable to provide information or absence of caretakers, 10{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} of the estimated sample size was added leading to a final sample size of 422 participants.

    Questionnaire Development

    The questionnaire was divided into three major sections: socio-demographic characteristics (age, gender, tribe, religion, education level, employment status, occupation, residence), herbal medicine use assessment (prevalence, and reasons for herbal medicine use), and factors associated with herbal medicine use with both open and closed-ended questions.

    Measurements

    The questions asked were modified from the International Questionnaire to Measure Use of Complementary and Alternative Medicine (I-CAM-Q); which aims to comparably assess the use of CAM internationally.11

    Data Analysis and Management

    Fully completed questionnaires were extracted from KoBo Toolbox® and exported to a Microsoft Excel 2016 for cleaning and coding. The cleaned data was exported to STATA 16 (StataCorp LLC, College Station, Texas, USA) for analysis. Numerical data were then summarized as means and standard deviations or median and range as appropriate. Categorical variables were summarized as frequencies and relative percentages. To assess the association between independent variables with herbal medicine use, chi-square test or Fishers’ exact test (for categorical variables) and Mann-Whitney U-test (for continuous variables) were used at bivariate analysis. All independent variables with p < 0.2 at bivariate analysis were included in the multivariable logistic regression models to adjust for confounders. A p < 0.05 was considered statistically significant.

    Ethics

    The study was performed according to the Declaration of Helsinki, after obtaining approval from Mulago Hospital Research and Ethics Committee (Approval number MHREC 2097). Consent forms were given to respondents before the initiation of the study.

    COVID 19 Precautions

    The study was conducted following the Ministry of Health and the National COVID-19 task force guidelines of Uganda.

    Results

    Characteristics of the Participants

    The study was terminated early because of a significant reduction in the number of patients hospitalized with COVID-19 and the closure of one of the CTUs. Of the anticipated 422 participants, we recruited 108 (25.6{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}). Of the 108 participants, 58 (53.7{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}) were female, with a median age of 38 (range: 20–75) years. Majority of the participants were from central Uganda (70.4{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, n = 76) and were Christians (66.7{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, n = 72), more than one-third attained tertiary level of education (37.7{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, n = 40). More than half were employed (56.5{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, n = 61) and were married (52.8{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, n = 57). Forty-nine (45.4{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}) participants had received at least one dose of the COVID-19 vaccine. Majority were on COVID-19 treatment (86.9{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}) and more than half were getting their treatment from Namboole CTU (58.3{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, n = 53). Table 1 summarizes the socio-demographic characteristics of participants.

    Table 1 Socio-Demographic Characteristics of Participants

    Herbal Medical Use

    Of the 108 participants, 58 (57.3{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}) ever used herbal medicine and the majority had used herbal medicine in the past 12 months (71.9{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, n = 41). Of those that had used herbal medicines in the past 12 months, 35 (85.4{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}) had used before a diagnosis of COVID-19, and 15 (36.6{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}) continued to use even while on treatment for COVID-19 (Figure 1). Their doctors or nurses asked almost half of the participants about herbal medicine (49.5{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, n = 53), and the majority reported some improvement after using herbal medicine (80.7{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, n = 46). Table 2 summarizes the use of herbal medicine by the participants. Of those that were using herbal medicines, efficacy, accessibility, and affordability were the frequently reported as the reasons for their use (n = 35, 60.3{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}), (n = 14, 24.1{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}) and (n = 14, 24.1{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}), respectively (Figure 2A). Gastrointestinal disturbances such as diarrhea, constipation, abdominal pain, and vomiting were the most commonly reported side effects associated with the use of herbal medicines (Figure 2B).

    Table 2 Herbal Medicine Use Among the Participants

    Figure 1 Herbal medical use before and after diagnosis of COVID-19 in the last 12 months. ε represents the total number of patients who had used herbal medicines in the last 12 months before this survey.

    Figure 2 (A) Reasons for use of herbal medicines among COVID-19 patients. (B) Common side effects of herbal medicines reported.

    Table 3 summarizes factors associated with herbal medicine use among the participants at bivariate analysis. Vaccination status (p = 0.004), level of education (p = 0.002), and accessibility of the herbalists vs conventional treatment (p < 0.001). Table 4 summarizes factors associated with herbal medicine use among the participants at multivariable logistic regression: being vaccinated (adjusted odds ratio (aOR): 3.1, 95{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} CI: 1.4–6.8, p = 0.005) and having attained a tertiary level of education (aOR: 6.2, 95{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} CI: 1.7–23.1, p = 0.006), as well as the accessibility of the herbalists (aOR: 31.2, 95{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} CI: 3.7–263.2, p = 0.002).

    Table 3 Bivariate Analysis for Socio-Demographic Factors Associated with Herbal Medical Use

    Table 4 A Multivariable Logistic Regression Showing Predictors of Use of Herbal Medical Use

    Discussion

    In the current study, the prevalence of herbal medicine use was found to be 57.3{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}. All participants who reported to have used herbal medicines started to use before hospital-based treatment a third of whom continued to use even after initiation of COVID-19 treatment. This finding was consistent with the results of a cross-sectional online survey among Vietnamese adults that found nearly half of the respondents to use herbal medicine for common illnesses during the COVID-19 pandemic.12 However, studies from Saudi Arabia report rather a higher prevalence (>90{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}) of herbal medicines use in the management of COVID-19 and other conditions.1,5,13 This big difference in the prevalence could be explained by the fact that our study assessed herbal medicine use among virologically confirmed patients, unlike the Saudi Arabian study whose participants reported to have used herbs for boosting their immunity and to improve general health and not to cure infection.13 However, a finding of herbal medicine use of more than half in our study is concerning given limited evidence supporting efficacy and safety of herbal medicines. In fact, previous studies in Uganda assessing herbal medicine use have reported a comparatively high prevalence.6,14,15 Easy access, affordability, cultural familiarity, and the unfavorable doctor–patient ratio in Uganda are the major factors leading to increased herbal medicine use.4

    Being vaccinated, having attained a tertiary level of education, as well as the accessibility of the herbalists were found to be significantly associated with herbal medicines in this study. This finding corroborates with the results of a study conducted in Vietnam which reported higher levels of income, urban dwellers, and higher levels of education to be more likely to use herbal medicines in the management of COVID-19.12 Although studies from other countries have reported a predilection of females towards herbal medicine use,12,16 this was not the case in our study. Our study revealed that participants who were vaccinated against COVID-19 continued to use herbal medicine for prevention and treatment. Notably, still, our participants believed that herbal medicines were safe and effective corroborating findings reported by Nguyen et al, in which nearly 70{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} of participants considered herbal medicines safe and effective.12 With limited research evidencing the efficacy, mode of action, and toxicity profiles of the common herbal medicines on market, the population is at great risk of drug-herbal medicine interactions, drug resistance, and unexplained adverse reactions. Efforts should be directed towards further studies to understand the role of herbal remedies in patient management and public awareness to guide their utilization.

    To the best of our knowledge, this is the first study in sub-Saharan Africa to assess the use of herbal medicine among COVID 19 patients hospitalized in treatment centers. Previous studies on herbal medicine use in Uganda and other sub-Saharan countries have focused on populations with HIV, hepatitis, and hypertension and there is a paucity of literature on the prevalence and rationale of herbal medicine use among patients with COVID-19 in sub-Saharan Africa.17,18 Findings from this study provide documented evidence on herbal medicine use among the population of COVID-19 patients, which will be used to promote public awareness, and knowledge of proper use of herbal therapies and contribute to the National Drug Authority’s objective to regulate the use of herbal medicine in Uganda. This information can also be used to promote activities to bring about improved communication between patients and health workers about herbal medicine use.

    Limitations

    Several limitations were taken into consideration as we interpreted these results. First, the study employed a non-random sample. Participation in the study was voluntary and no information was available about the characteristics of those who did not participate. Secondly, the cross-sectional design of our study does not allow for a causal interpretation of the results. Thirdly, the CTUs employed were geographically situated in town and this could have limited access to populations in rural areas who could have reflected different study findings. However, despite these limitations, this is the first study in Uganda assessing the prevalence of herbal medicine use and its associated factors among hospitalized COVID-19 patients.

    Conclusion

    The use of herbal medicine during the COVID-19 pandemic is a widespread practice among the general population in Uganda amidst unpublished evidence of their safety and efficacy. Continuous public health awareness is suggested on the different natural remedies and further studies on the role of herbal medicine in patient management are recommended.

    Data Sharing Statement

    The data used to support the results of the research are available from the corresponding author upon request.

    Acknowledgments

    The authors would like to acknowledge administrative support from Mulago National Referral hospital, Namboole COVID-19 Treatment Unit, and Kiruddu Referral Hospital.

    Author Contributions

    All authors made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data, took part in drafting the article or revising it critically for important intellectual content, agreed to submit to the current journal, gave final approval to the version to be published, and agree to be accountable for all aspects of the work.

    Funding

    Research reported in this publication was supported by the Fogarty International Center of the National Institutes of Health, US Department of State’s Office of the US Global AIDS Coordinator and Health Diplomacy (S/GAC), and President’s Emergency Plan for AIDS Relief (PEPFAR) under Award Number 1R25TW011213. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

    Disclosure

    The authors declare no potential conflicts of interest for this work.

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