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CDFW News | Mountain Lion P-22 Compassionately Euthanized Following Complete Health Evaluation Results

Mountain Lion P-22 Compassionately Euthanized Pursuing Comprehensive Health Evaluation Effects

Video clip of Dec. 17 (10 a.m.) media update

Just after acquiring a detailed medical evaluation, CDFW has acquired a distinct photo of the mountain lion P-22’s health-related condition and total health. He experienced several serious accidents and serious health issues. Centered on these elements, compassionate euthanasia less than standard anesthesia was unanimously recommended by the clinical team at San Diego Zoo Safari Park, and CDFW officers made the selection to do so on Saturday, Dec. 17.

P-22 been given a complete diagnostic analysis by the Safari Park’s wildlife well being workforce, less than general anesthesia. The considerable analysis incorporated a actual physical exam, organ functionality checks, infectious sickness screening, ultrasonography and computed tomography (CT) scans of the cranium, chest and stomach.

The success of these exams and screenings confirmed important trauma to the mountain lion’s head, proper eye and internal organs, confirming the suspicion of new harm, these types of as a car strike. The trauma to his inner organs would call for invasive surgical repair service.

The evaluation also revealed sizeable pre-current ailments, which include irreversible kidney sickness, continual bodyweight loss, comprehensive parasitic pores and skin infection in excess of his entire system and localized arthritis, all of which have led to the regrettable deterioration in P-22’s total issue.

P-22’s highly developed age, combined with serious, debilitating, daily life-shortening conditions and the clear need for in depth prolonged-term veterinary intervention still left P-22 with no hope for a optimistic outcome. His poor situation indicated that he may also have experienced more fundamental disorders not nonetheless totally characterized by diagnostics.

The Safari Park wildlife treatment crew consists of 6 veterinarians with extra board certification in zoologic medication. Moreover, 4 veterinary experts (board certifications in ophthalmology, radiology and medical procedures) were consulted.

CDFW is not trying to find info on a car or truck collision. This problem is not the fault of P-22, nor of a driver who may well have hit him. Rather, it is an eventuality that occurs from habitat decline and fragmentation, and it underscores the want for thoughtful building of wildlife crossings and nicely-prepared spaces that give wild animals room to roam.

On Thursday, Dec. 8, CDFW declared their intent to capture the world-renowned mountain lion and carry him in for a overall health analysis. On Monday Dec. 12, P-22 was captured by CDFW and National Park Support and brought in for analysis. On Dec. 13, CDFW issued a FAQ doc about P-22 and held a media briefing to present an update on his problem.

CDFW needs to thank our a lot of associates. This has been a challenging journey for all of us. None extra so than the dedicated staff members who have been caring for him in excess of this week, the biologists who have examined his remarkable everyday living, and the lots of compassionate people who have been his neighbors and adopted his travails.

Mountain lion P-22 has experienced an remarkable lifestyle and captured the hearts of the people of Los Angeles and beyond. The most complicated, but compassionate decision was to respectfully limit his suffering and stress by humanely ending his journey.

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Media speak to:
Jordan Traverso, CDFW Communications, (916) 212-7352

December 18, 2022
Cannabis For Pain Relief? Review of 20 Studies Provides Sobering Results : ScienceAlert

Hashish is a single of the most extensively applied medicines in the environment. Though there are only a several nations around the world where hashish is authorized for recreational use, a lot of much more nations have legalized the use of cannabis for clinical explanations.

Decreasing ache is one particular of the most widespread causes people today report working with healthcare cannabis. According to a US national survey, 17 percent of respondents who experienced reported using cannabis in the previous yr had been approved clinical cannabis.

When it comes to self-medicine, the quantities are even higher – with estimates that concerning 17-30 per cent of grown ups in North The us, Europe and Australia reporting they use it to regulate pain.

Though hashish (and hashish-derived products and solutions, these types of as CBD) may possibly be greatly employed for minimizing ache, how productive it actually is in executing this is still unclear. This is what our recent systematic review and meta-analysis sought to uncover.

Our review, revealed in the Journal of the American Professional medical Affiliation, indicates cannabis is no much better at relieving discomfort than a placebo.

To carry out our research, we appeared at the results of randomized managed trials in which cannabis was in comparison with a placebo for the treatment of clinical pain. We especially provided reports that when compared the transform in agony depth before and after remedy. In whole, we looked at 20 scientific tests involving just about 1,500 men and women altogether.

The experiments we integrated seemed at a wide range of different soreness circumstances (these as neuropathic discomfort, which is brought on by hurt to the nerves, and a number of sclerosis) and kinds of hashish goods – like THC, CBD and artificial hashish (these types of as nabilone). These solutions were being administered in a wide range of strategies, which includes by using pill, spray, oil and smoked.

The majority of the study’s contributors were female (62 percent) and aged between 33 and 62. Most of the experiments were carried out in the US, Uk or Canada – nevertheless we also bundled studies from Brazil, Belgium, Germany, France, the Netherlands, Israel, the Czech Republic and Spain.

Our meta-examination confirmed that agony was rated as currently being drastically fewer rigorous after treatment method with a placebo, with a reasonable to huge outcome depending on each and every person. Our workforce also noticed no substantial variation between cannabis and a placebo for minimizing discomfort.

This corroborates the outcomes of a 2021 meta-evaluation. In simple fact, this 2021 meta-analysis also identified that larger-high-quality studies with greater blinding techniques (exactly where both individuals and scientists are unaware of who is getting the energetic compound) in fact had better placebo responses.

This suggests that some placebo-managed cannabis trials fail to be certain suitable blinding, which may possibly have led to an overestimation of the effectiveness of medical hashish.

Our examine also discovered a lot of individuals can distinguish among a placebo and active hashish, despite obtaining the exact odor, flavor and look. If they are informed that they are acquiring or not acquiring cannabinoids, they are a lot more possible to deliver a biased assessment of the usefulness of the intervention. So to make sure researchers are observing the true impact of cannabis, contributors won’t be able to know what they receive.

Media coverage

Our examine also examined the way the research ended up protected by the media and academic journals to see no matter if it connected to the therapeutic effect members reported. We did this simply because study has proven media coverage and details on the net can influence the anticipations that a man or woman has of a treatment method.

Media existence was measured by way of Altmetric, which is a strategy of analyzing mentions of a review in the media, blogs and on social media. Academic effect was measured in terms of citations by other scientists. We observed a whole of 136 information things in the media and weblogs.

We classified coverage as optimistic, negative or neutral relying on how the benefits ended up presenting about the usefulness of hashish for managing agony. The mind-boggling the vast majority of news merchandise documented that hashish experienced a constructive result for treating agony. This indicates that media coverage to hashish tends to be constructive, irrespective of what a study’s outcomes truly have been.

There are a lot of illustrations of the connection concerning therapy anticipations and placebo responses. If a person thinks they will encounter aid from their suffering by employing a certain item or treatment method, this can change the way they conclude up perceiving incoming agony alerts – making them imagine their agony is considerably less critical. Recent evidence suggests that the placebo outcome may perhaps operate even if we’re offered with proof that contradicts our preliminary expectations.

We are unable to say with 100 {fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} certainty that media protection is dependable for the high placebo response observed in our overview. But given placebos have been demonstrated to be just as very good as hashish for handling ache, our benefits clearly show just how critical it is to feel about the placebo effect and how it can be motivated by exterior components – these kinds of as media protection.

For solutions, these kinds of as cannabinoids, that obtain a good deal of media focus, we need to have to be more arduous in our clinical trials.

Filip Gedin, Postdoctoral Researcher, Ache investigation, Karolinska Institutet.

This posting is republished from The Discussion beneath a Artistic Commons license. Read through the unique article.

November 30, 2022
Alternative anti-HIV strategy generates promising results in a phase I clinical trial

Due to the fact the first studies of HIV infection in the early 1980s, a number of medical trials have tested prospective vaccines towards the virus, but however, HIV has many protection mechanisms that protect against a person’s immune method from mounting an helpful response following HIV vaccination. An alternative anti-HIV technique identified as Vectored ImmunoProphylaxis (VIP) designed by scientists at the Ragon Institute of MGH, MIT and Harvard and Massachusetts Standard Hospital (MGH) will involve an adeno-linked viral (AAV) vector to produce directions to muscle cells to pump out antibodies that block the virus. The technique not long ago created promising outcomes in a section I clinical demo that was executed by the Nationwide Institutes of Overall health and is revealed in Nature Medicine.

AAV vectors can be securely employed in people to deliver DNA to cells, and two AAV-based gene therapies are now Food and drug administration authorized. In this medical demo, the AAV vector intended by MGH investigators carries the genetic sequence for what is termed a broadly neutralizing HIV-1 antibody that blocks HIV’s ability to bind to CD4, an immune cell’s receptor that HIV targets just before infecting the mobile. When injected into a client, the AAV treatment (named AAV8-VRC07) enters muscle cells, the place the genetic sequence is examine and translated to produce massive quantities of the broadly neutralizing antibody (referred to as VRC07) that are pumped out of the cells and vacation by means of the blood to seek out their target. The result is that several antibodies circulate to block any interaction among HIV and the CD4 receptor on immune cells, primarily shutting the doorway on HIV’s entry into the cells.

The stage I clinical trial enrolled eight grown ups with HIV who were on stable antiretroviral remedy for at the very least a few months. Investigators located that intramuscular injection of AAV8-VRC07 was risk-free and well tolerated. All eight folks generated measurable quantities of VRC07 in the blood, with maximal VRC07 concentrations in 3 people. In 6 people today, these quantities remained secure and close to maximal focus for up to a few decades of follow-up. (The demo is ongoing, and some contributors have not been adopted as lengthy as others.) Three of the 8 contributors showed signs of an anti-drug antibody response directed against a part of VRC07, and this response appeared to reduce the production of VRC07 in two of the members.

“This function represents the first successful AAV-primarily based manufacturing of a monoclonal antibody of any type in people today,” says co-author Alejandro B. Balazs, PhD, who made the vector employed in the demo and is a principal investigator at the Ragon Institute of MGH, MIT and Harvard, in which his laboratory is continuing to create this technological know-how. “It is also the first time we have experienced an strategy able of yielding broadly neutralizing antibodies from HIV in people,” he claims.

Balazs notes that the success have extensive-ranging scientific implications for probably blocking or dealing with HIV and other bacterial infections. “The results show that the system we intended is able of generating lengthy-lived expression of an antibody from a single injection. Specified our potential to encode any sought after antibody into these vectors, we could be in a position to make productive preventive treatment options versus a vast selection of infectious ailments from malaria to COVID-19,” he says. “This know-how also has the potential to be applied to the shipping of other biologic drugs to address a extensive array of disorders from autoimmunity to most cancers.”

The engineering was in the beginning designed at the California Institute of Technology in the laboratory of Nobel laureate David Baltimore, PhD, by Balazs when he was a postdoctoral fellow. The Vaccine Investigate Middle of the NIH supported the clinical review, which was performed at the Nationwide Institutes of Wellbeing Medical Middle.

Supply:

Massachusetts General Clinic

Journal reference:

Casazza, J.P., et al. (2022) Protection and tolerability of AAV8 delivery of a broadly neutralizing antibody in grown ups dwelling with HIV: a stage 1, dose-escalation demo. Nature Drugs. doi.org/10.1038/s41591-022-01762-x.

April 12, 2022
Purpose, Procedure, Results & More
An ultrasound is a examination that uses seem waves to produce a photo of what is inside of your body. When this exam is applied for bladder concerns, like an overactive bladder, it can support a health care provider determine out the result in.

This noninvasive check is generally done on a complete bladder, but it should not be agonizing. The effects of this exam are applied by a medical professional to come up with a analysis and procedure system to enable relieve your signs.

This short article will take a look at the specifics of bladder ultrasounds, what they can detect, and what to anticipate if you’re possessing a single.

A bladder ultrasound is performed when a health practitioner wants to closely take a look at the structure or functionality of your bladder.

The bladder is a muscular sac that gets urine from your kidneys, stretching to hold the fluid right up until you launch it in the course of urination. Bladder manage, or your potential to control these muscle groups, makes urination a prepared and purposeful undertaking.

Even so, there are many troubles that can complicate the approach of urination.

About a quarter of all individuals in the United States encounter some stage of incontinence, or the lack of ability to maintain urine in the bladder till you purposely launch it.

There are quite a few results in of incontinence, and it can be difficult for a health care provider to pinpoint a purpose for the issue just by asking you questions or inspecting the outside the house of your physique.

The following signs or symptoms may guide a medical professional to buy a bladder ultrasound:
In some services, you may well require to see a unique technician for an ultrasound. But some health care offices can do this examination in the examination home through a routine appointment.

Whether you have the exam finished in an assessment area or an imaging centre, the course of action will be equivalent:

Make guaranteed your bladder is complete. Whilst this can make the mild force applied all through the ultrasound a little bit not comfortable, a entire bladder can enable change other organs, like the bowels or uterus, to get a clear picture of the bladder. Audio waves also journey improved by means of fluids, so a medical doctor can get a improved image when these beams journey by way of a entire bladder.

Get undressed. When your physician or technician is ready to start out the check, you will be requested to remove your garments — or at the very least your trousers and underwear. You could be presented a medical center gown or drape for the take a look at.

Get in placement. You will will need to be lying down for this test.

Gel is utilized. Your technician will use gel to the pores and skin over your pelvic region. This gel allows transmit the seem waves from the transducer, or ultrasound probe, into your human body.

The scan begins. You will not come to feel the ultrasound waves as they are beamed within you, but you could experience your clinician relocating the transducer across the surface area of your pores and skin concerning your tummy button and pubic bone in get to look at the entire bladder.

See your bladder. The sound waves will deliver a whooshing audio and show live illustrations or photos of the inside of of your bladder. You may possibly be in a position to see these shots in the course of the examination. The technician will report samples and nonetheless visuals for a expert to assessment.

Accomplished! When all the photos are gathered, the technician will wipe the gel from your pores and skin, and you can empty your bladder and get dressed.
Very simple types of bladder ultrasounds, known as bladder scans, can deliver fast results. These scans are commonly utilised only to measure the quantity of urine in your bladder. A diagnostic bladder ultrasound creates much more intricate images about the dimension, fullness, and lining of the bladder.

A physician might comprehend what the ultrasound is exhibiting, but a radiologist will commonly interpret the photos and create a report for your medical doctor to evaluate.

The medical doctor will make an formal prognosis just after an ultrasound based on the report from the radiologist. Apart from overactive bladder, a bladder ultrasound may possibly also be in a position to enable diagnose bladder most cancers.

Following a analysis, the doctor can get started treatments or therapies to assistance your signs, these as medications or pelvic ground exercise routines. Often, additional screening may be wanted.

If the health practitioner is not specific of your prognosis just after a bladder ultrasound, they could possibly buy other tests.

Some other checks that can be used to look at the bladder include:

There are no dangers or side results from a bladder ultrasound.

You could be uncomfortable from a full bladder through the check, but the complete system is noninvasive, painless, and really should get considerably less than an hour.

If you have clinical insurance, your copayment for a bladder ultrasound can differ or might even be cost-free. With out insurance policy, the normal expense of an ultrasound in the United States is amongst about $250 and $400.

If you have Medicare, an ultrasound might be protected less than your Component A protection if you have the method in the course of an inpatient healthcare facility keep.

At an outpatient facility, an ultrasound is coated by Medicare Aspect B. Your share of the price can be in between about $17 and $30 based on in which the check is done.

A bladder ultrasound is a painless and noninvasive device that can help you get answers for your bladder complications.

If you experience issues like urine leaking or incontinence, a medical doctor may want to do an ultrasound of your bladder to enable make an exact diagnosis.

Overactive bladder is a common induce for these indicators, and an ultrasound can be employed to enable rule out other challenges, like bladder cancer or structural difficulties.
March 7, 2022
5 Easy-To-Follow Fitness Tips For Successful Results
PHOTO: Evolve MMA

Fitness is both an end goal and the process that gets you there. It is a lifestyle that you need to build, block by block. These building blocks take the form of small decisions that you need to make regularly.

This article will explore a few helpful tips that help you to achieve good results that stay with you for the long haul.

Doable fitness goals that are worth pursuing

Taking on a fitness journey is a lifestyle change that quickly improves your physical and emotional health. Regular and consistent exercise also sculpts the body, but only in the medium to long term. For many, the lack of immediate results in the weight loss and muscle departments can be demotivating.

For this reason, you should start your fitness journey with very realistic, gradual milestones. Your fitness journey will be a marathon, after all, not a sprint. The strategies below will help you make enduring changes that will pay off for a long time to come.

Starting over

This section is for anyone who is looking to take up fitness after an extended hiatus. The mere thought of starting a new fitness journey can be intimidating. Your mind may trick you into thinking that you need to clear some impossible hurdles even before starting. There’s only one way to get through this: Start small.

If the idea of going to the gym seems like too much, start with five or ten minutes of exercise right in your home. Make it a point to make this small, daily effort towards exercise. This will rewire your brain to accept that you are capable of setting a goal and working on it. Here is how to rewire your brain to make yourself more consistent.

1) Forming a habit and sticking with it

You’ve overcome the mental block of starting your fitness journey, and now you have to find the motivation to keep going. So there you are, faithfully showing up for every one of your workouts, until one day you just don’t feel like it.

Maybe you didn’t have the energy to wake up early one morning, or a hard day’s work had you running on empty. Missing one morning or evening session can lead to erratic workout patterns, snowballing into another long hiatus. Here’s how to avoid this:

Build a habit by starting small

Diet and exercise are habits you form mentally, even as you form them physically. Your mind can override your body after a long day, and it can wake you up when you would rather sleep in. Here is how to turn the mind into your very own fitness trainer:
- Start with short, easy sessions that are a walkover and stick with the ‘easy’ setting for a week or two.
- Proceed to turn it up a notch to give your body and mind something new to work with. Take care not to discourage yourself by pushing too hard; this is about forming a habit more than anything else.
- Slot your workouts for a time when you have the energy and concentration to get through a few minutes of exercise.
It will take a couple of weeks for your mind to adopt exercise as part of your lifestyle. There are no shortcuts to forming a habit, except for time and repetition. The good news is that it is easy to remain consistent throughout your fitness journey once the habit forms. For motivation, you can change up your workouts whenever you start to get bored.

2) Build muscle to burn fat

PHOTO: Evolve MMA

This applies to anyone, no matter their fitness goals. If you want to lose weight, you need to build muscle and burn fat. If you want sculpted abs, you need to build muscle and burn fat.

You do this by incorporating high-intensity exercise and strength training into your cardio workout. This prevents the loss of muscle while stimulating the formation of new muscle tissue. Muscle burns more calories than other tissue types, which helps you reach your fitness goals that much faster.

3) Some foods will help while others will hurt

You still need fuel to exercise even if weight loss is your ultimate fitness goal. You can take in small amounts of complex carbohydrates before your workouts. This measure becomes even more important as you increase the intensity of your workouts.

Avoid fatty foods before exercise since they can make you sluggish. Also, remember to hydrate before, during, and after your workout sessions. Lastly, reward yourself with a healthy snack a short while after your workouts, preferably a protein-rich one.

4) Find exercises and activities that suit you

Don’t take up jogging if you despise jogging. Stay away from gym settings if you hate the gym. Instead, take up the kinds of activities that you enjoy. If it helps to watch TV as you ride an exercise bike, do that. Maybe competitive sports are more your speed, so find people who like the same sport as you.

Better still, take up martial arts like Muay Thai, which can help you burn up to 1000 calories per hour. There’s a whole world of sporting activities to choose from. Pick one that works with your schedule and your preferences.

5) Find a way to stay accountable

We all need a little help to maintain our enthusiasm as we turn a fitness journey into a healthy lifestyle. Find a friend or support group that will either work out with you or check on you periodically. Having someone to answer to may provide a timely dose of motivation on days when you feel like you just don’t have it in you.

Put your best foot forward

Setting a fitness goal and reaching that goal is an investment that pays off in a big way. We appreciate that you’re already putting your energy into doing something good for yourself just by reading this. Martial arts training provides a fun activity that can burn up to 1000 calories per hour, bringing you closer to your fitness goals.

This article, “5 Easy-To-Follow Fitness Tips For Successful Results”, originally appeared on Evolve MMA, Asia’s No. 1 martial arts organisation.
November 24, 2021