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  • Health Tips Fitness Know How Exercise And Workout Side Effects

    Health Tips Fitness Know How Exercise And Workout Side Effects

    Wellness Ideas : कोविड के बाद वर्क फ्रॉम होम का ट्रेंड बढ़ा है. घर में बैठे-बैठे फिजिकल एक्टिविटी पर फुल स्टॉप सा लग गया है. इसका असर यह हुआ है कि पूरा रूटीन ही बिगड़ा हुआ है. इससे सेहत (Wellness) को भी कई तरह की परेशानियां हो रही हैं. इन सबके बीच जो सबसे अच्छी बात है, वह यह कि आजकल लोग हेल्थ और फिटनेस को लेकर काफी अवेयर भी हुए हैं. एक्सरसाइज, वर्कआउट और योग उनकी दिनचर्या का हिस्सा है लेकिन क्या आप जानते हैं कि अगर सही तरह से वर्कआउट न किया जाए तो यह फायदे की जगह नुकसान (training aspect consequences) भी पहुंचा सकता है. आइए जानते हैं..

     

    योग करना

    प्राचीनकाल से ही योग हमारी लाइफ का हिस्सा रहा है. इससे न सिर्फ शरीर बल्कि दिमाग भी एक्टिव रहता है. लेकिन अगर इसे गलत तरीके से किया जाए तो इसके नुकसान भी हो सकते हैं. योग में कुछ चीजें नहीं करने की सलाह दी गई हैं. जैसे- हर किसी को शीर्षासन नहीं करना चाहिए. ऐसे लोग जिन्हें किसी तरह की पेट की बीमारी रही हो, उन्हें दबाव डालने वाले योग से परहेज करने को कहा गया गया है. ओम का उच्चारण भी कुछ परिस्थितियों में मना होता है. ऐसे में अगर आप योग करते हैं तो एक सही प्रशिक्षक से मदद लें.

     

    ट्रेडमिल पर चलना

    आजकल हर किसी के पास ट्रेडमिल या जिम वाली साइकिल है. इन मशीनों पर अचानक या जरूरत से ज्यादा चलना नुकसानदायक हो सकता है. आजकल कई ऐसे केस आ रहे हैं, जब ट्रेडमिल पर चलते-चलते ही हार्ट अटैक आ जाता है. ऐसा तब ज्यादा हो सकता है, जब वजन ज्यादा हो और बहुत दिनों बाद अचानक से एक्सरसाइज की जा रही हो. हाई बीपी और शुगर अनकंट्रोल की स्थिति में ऐसा होता है. इसका एक कारण यह भी होता है कि ट्रेडमिल या जिम साइकिलिंग हमेशा बंद जगह पर होती है, इससे पर्याप्त ऑक्सीजन नहीं मिल पाता और सेहत के लिए खतरा बन जाता है.

     

    रनिंग या जॉगिंग

    रनिंग या जॉगिंग सबसे अच्छी एक्सरसाइज में से एक है. इसका फायदा पूरी बॉडी को होता है लेकिन अगर आप किसी दिन अचानक से दौड़ना शुरू कर देते हैं तो यह फायदेमंद नहीं होता है. 40 साल के बाद, बढ़े वजन के साथ अचानक दौड़ना या जॉगिंग हड्डियों के साथ दिल के लिए नुकसानदायक होता है. रोजाना वर्कआउट करने वाले, खिलाड़ी या आर्मी जवान रोजाना कई-कई किलोमीटर तक दौड़ते, इसका फायदा उन्हें मिलता है. यह उनका रूटीन होता है और इसके लिए वे वॉर्मअप, स्ट्रेचिंग, सही रूटीन और सही तरीके से दौड़ने की ट्रेनिंग लेते हैं. यह भी फैक्ट है कि दौड़ते या जॉगिंग करने के दौरान शरीर का पूरा वजन एक साथ पैरों पर पड़ता है. इसका नुकसान कड़क हो चुकी मसल्स और दिल को हो सकता है. दौड़ने की शुरुआत करनी है तो सबसे पहले सही शूज चुने और लगातार तेज चलकर प्रैक्टिस करें. पहले 5 मिनट के दौड़ से शुरुआत करें और फिर धीरे-धीरे इसे आगे ले जाएं.

     

    बाकी एक्सरसाइज

    जुंबा, एरोबिक्स, रस्सी कूदना, मार्शल आर्ट जैसी एक्टिविटीज को कभी भी अचानक से शुरू न करें. इसका नुकसान हड्डियों और मसल्स पर तो होता ही है, रीढ़ को भी जोखिम में डाल देता है. इसके साथ ही हार्ट, लिवर जैसे अंग भी प्रभावित होते हैं. ओवरवेट हैं तो सबसे पहले किसी एक्सरपर्ट से सही एक्सरसाइज चुने और फिर आगे बढ़ें.

     

    यह भी पढ़ें

    Check out down below Wellbeing Tools-
    Estimate Your Entire body Mass Index ( BMI )

    Work out The Age By way of Age Calculator

  • Verti CBD Gummies REVIEWS [Scam OR Legit] Shark Tank Exposed Side Effects?

    Verti CBD Gummies REVIEWS [Scam OR Legit] Shark Tank Exposed Side Effects?

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  • Osteoporosis Medications: Benefits vs. Side Effects

    Osteoporosis Medications: Benefits vs. Side Effects

    There are many medication options to treat osteoporosis, a disease that weakens bones and makes them brittle and prone to breaking. When choosing the right medicine, several factors must be considered, including menopausal status, disease severity, and the drug’s cost, risks, and delivery method—injection, oral, or intravenous (IV) infusion.

    This article reviews the factors that go into choosing an osteoporosis drug. A list of osteoporosis medications, including their mode of action and side effects, is also provided.

    IndiaPix/IndiaPicture / Getty Images


    Osteoporosis Medications: Deciding Factors

    Osteoporosis causes no symptoms, including pain (unless a fracture is present). Despite being a “silent” disease, medication may be necessary to reduce your fracture risk. Fractures can be devastating and are associated with a poor quality of life.

    As you discuss osteoporosis treatment with your healthcare provider, the following factors will be taken into account.

    Terminology

    Verywell Health prefers to use inclusive terminology. But when citing health authorities or research, the terms for gender and sex from those sources are used. Food and Drug Administration (FDA) guidelines for drug indications often use binary gender terms.

    In this article, “female” refers to people assigned female at birth, and “male” refers to people assigned male at birth. Talk to a healthcare provider to determine whether screening or a medication is indicated for you.

    Menopause, Gender, and Age

    Postmenopausal females are at high risk for developing osteoporosis and bone fractures because they have low estrogen levels.

    In addition to menopause and declining estrogen levels, bones naturally weaken and thin with advancing age. As such, medication may be advised to treat postmenopausal females and males aged 50 years or older with osteoporosis.

    Overall, patient sex and age both influence the choice of therapy. This is because some osteoporosis drugs are FDA-approved for both older males and postmenopausal females. Other osteoporosis medications are only approved for postmenopausal females. Likewise, some osteoporosis medications are better for younger postmenopausal females and others for older ones.

    Extent of Bone Loss

    The extent of your bone loss is reflected in your T score.

    The T score is a number that compares your bone’s quality with that of an average young person with healthy bones. Individuals with normal bone density have a T score between plus 1 and minus 1, whereas individuals with osteoporosis have a T score of minus 2.5 or less. 

    Since osteoporosis medications work in distinct ways and have varying levels of effectiveness, the severity of your osteoporosis impacts your choice of therapy.

    Side Effects and Personal Preferences

    Osteoporosis medications have unique side effect profiles and contraindications (reasons not to take the drug). You may not be able to tolerate certain drugs, or they may be unsafe for you to take.

    Moreover, osteoporosis medications differ in their delivery method and dosing schedules. You may prefer, for example, a pill vs. a shot or a monthly vs. daily medication.

    Cost and Insurance Coverage

    Insurance companies usually cover osteoporosis medication, but how much depends on your insurance type and co-pay. If you have Medicare, the cost of prescription drugs can be lowered through a benefit called Medicare Part D.

    If you are considering an osteoporosis medication, check the medication or your insurance company’s website to find out if it’s covered. Your healthcare provider can also refer you to a social worker or billing specialist for assistance.

    Length of Time on Medication and Monitoring

    When taking an osteoporosis medication, your healthcare provider will monitor you periodically to see how well it works and evaluate for any adverse reactions.

    Some individuals may need to change their drug, perhaps because they continue to lose bone or develop an intolerable side effect. Also, some medications can only be used for a certain length of time due to safety concerns or reduced benefits with long-term use.

    The degree of monitoring required and the time you can take a drug can ultimately affect your choice.

    List of Osteoporosis Medications

    Osteoporosis medications work to prevent fractures by either slowing bone loss or forming new bone; however they cannot fully reverse the condition.

    Here is a list of osteoporosis medications, including their mode of action and how they are taken. A summary chart that includes the drugs’ common and serious side effects is also provided.

    Bisphosphonates

    Bisphosphonates are the most commonly used drugs to treat osteoporosis.

    They are used to treat males and postmenopausal females with osteoporosis and steroid-induced osteoporosis (bone weakening caused by chronic steroid use, for example, prednisone).

    Bisphosphonates work by slowing the natural breakdown of bone. Several types are available, varying in their dosing and delivery method (pill, liquid, or IV infusion).

    Options include:

    • Binosto, Fosamax (alendronate): This pill is taken once daily or weekly.
    • Actonel, Atelbia (risedronate): This pill is taken once daily, weekly, or monthly.
    • Boniva (ibandronate): This pill is taken once daily or monthly or as an injection every three months.
    • Reclast (zoledronic acid): This IV infusion (through the vein) is given once a year.

    For oral bisphosphonates, the pill must be taken in the morning on an empty stomach with 4 ounces (half a cup) of water. You then need to sit or stand upright for 30 minutes before eating. The purpose is to avoid irritating the esophagus (the tube that carries food from your mouth to your stomach.

    Individuals who cannot follow these instructions or those with esophageal disorders should not take an oral bisphosphonate.

    Bisphosphonates are generally taken for three to five years. Taking one for seven years or more may rarely increase the risk of an unusual bone break in the thigh bone (atypical femur fracture).  

    Also, some people worry about developing a complication called osteonecrosis (death of a portion of bone) of the jaw with bisphosphonates. This risk is minimal and more common in individuals taking a bisphosphonate as part of their cancer treatment, not for osteoporosis.

    Prolia (Denosumab)

    Prolia (denosumab) is used in postmenopausal females at high risk for fracture or who have not responded to or tolerated other osteoporosis drugs.

    High risk for fracture is generally defined as someone with a history of osteoporotic fracture or multiple risk factors for fracture,

    Prolia is injected underneath the skin, usually by a healthcare provider, once every six months. It works by blocking a protein involved in the formation of cells that break bone down (osteoclasts).

    Prolia can cause or worsen low calcium levels in the blood (hypocalcemia), so this abnormality must be corrected before starting Prolia (if present).

    In addition, stopping Prolia is associated with rapid bone loss. As a result, a drug holiday (taking time off from using the drug) is not advised for people taking Prolia. If the drug needs to be stopped, a bisphosphonate is usually prescribed to preserve bone density.

    Evista (Raloxifene)

    Evista (raloxifene) is a type of drug called a selective estrogen receptor modulator (SERM).

    What Is a SERM?

    A SERM is an estrogen-like medication that mimics estrogen in some parts of the body and blocks the effects of estrogen in other parts. 

    Evista can slow down bone loss in postmenopausal females and is taken as a pill once a day.

    Evista increases the risk of death due to stroke in postmenopausal females with (or those at risk for) stroke. It also increases the risk of blood clots in your legs (deep vein thrombosis). lungs (pulmonary embolism), and eyes. As such, females at risk for stroke or blood clots should not take this medication.

    Parathyroid Hormone/Parathyroid Hormone-Related Protein

    Forteo (teriparatide) or Tymlos (abaloparatide) are approved for postmenopausal females at high risk for fracture.

    Forteo is also FDA-approved for males at high risk for fractures and for treating osteoporosis in people of any sex associated with long-term steroid therapy (taking 5 milligrams or more of prednisone daily).

    Forteo and Tymlos work by stimulating bone formation. They are given as daily injections underneath the skin and are available in prefilled syringe pens so people can administer the shots themselves at home.

    Forteo and Tymlos are used for up to two years. This restriction is due to the possible risk of developing osteosarcoma (a type of bone cancer). Keep in mind, though, osteosarcoma has only been seen in studies of animals, not humans.

    Evenity (Romosozumab)

    Evenity (romosozumab) may treat postmenopausal females at a high risk of fractures. A healthcare provider gives Evenity as a monthly injection underneath the skin.

    Evenity enhances bone formation by blocking sclerostin, a protein that stops building new bone. The drug can only be used for up to one year because it becomes less effective at reforming bone.

    Also, Evenity may increase the risk of heart attack and stroke, although it’s unclear why. Until more is known, the drug should not be given to people with a history of or an increased risk of heart attack or stroke.

    Summary of Osteoporosis Medications
      Delivery Dosing Common Side Effects Serious Side Effects
    Oral or Injected Bisphosphonate (e.g., Fosamax, Actonel, Boniva) Pill or injection Daily, weekly, monthly, or every three months (injection) Back pain, joint/arm/leg pain, nausea, heartburn, stomach pain, Severe esophageal inflammation, severe muscle/joint/bone pain, low blood calcium levels, jaw osteonecrosis, atypical femoral fracture
    Reclast (zoledronic acid) Infusion Yearly Fever, muscle/joint aches, headache, arm/leg pain Low blood calcium levels, jaw osteonecrosis, atypical femoral fracture, severe muscle/joint/bone pain
    Prolia (denosumab) Injection Every 6 months Back pain, arm/leg pain, muscle/joint pain, high cholesterol, bladder infection Low blood calcium levels, jaw osteonecrosis, atypical femur fractures, serious infections
    Evista (raloxifene) Pill Daily Hot flashes, leg cramps, leg swelling, flu-like symptoms, joint stiffness, sweating Increased risk for blood clots and death due to stroke in patients with (or at risk for) stroke
    Forteo (teriparatide) Injection Daily Joint stiffness, pain, nausea, high calcium levels Osteosarcoma (in animal studies)
    Tymlos (abaloparatide) Injection Daily Calcium in the urine, dizziness, nausea, headache, palpitations, unusual tiredness, stomach pain Osteosarcoma (in animal studies)
    Evenity (romosozumab) Injection Monthly Joint stiffness, headache Low blood calcium levels, jaw osteonecrosis, atypical femur fractures, may increase risk of heart attack and stroke
    Source

    Medication Alternatives

    There is limited scientific evidence supporting the benefits of alternative treatments for osteoporosis, including taking traditional Chinese medicine herbs or engaging in practices like yoga and acupuncture.

    That said, these therapies may be reasonable to incorporate into your osteoporosis treatment plan, mainly if they help you feel better. Before starting any new treatment, always discuss it first with a healthcare provider. You want to be sure the therapy is safe and proper for your care.

    An Integrative Approach to Osteoporosis Treatment

    Osteoporosis cannot be fully cured or reversed, but there are things you can do to slow bone loss and help rebuild bone tissue.

    Take an integrative approach, which includes healthy lifestyle behaviors and, sometimes, medication.

    Healthy lifestyle behaviors include:  

    • Eat a well-balanced diet plentiful in fruit and vegetables that include calcium, vitamin D, and protein. Supplements, especially vitamin D, may be needed.
    • Participate in regular exercise. Include weight-bearing exercises (e.g., walking or playing tennis) and resistance exercises (e.g., lifting weights).
    • Avoid secondhand smoke, and quit smoking if you do.
    • Drink alcohol in moderation, which means no more than one drink a day for females and no more than two daily drinks for males.
    • Engage in fall-prevention strategies (e.g., declutter, remove rugs, improve room lighting, wear supportive shoes).

    Summary

    Osteoporosis is associated with bone thinning and weakening, which makes bones prone to breaking. Treatment with medication is sometimes recommended to prevent bone breaks.

    Several drugs are available, including bisphosphonates, estrogen-like medications, and parathyroid hormone. These drugs vary in their modes of action, delivery method, dosing schedule, and side effects. Such factors must be carefully considered when making the decision about the right therapy for you.

    Frequently Asked Questions

    • Can you treat osteoporosis without medication?

      Healthy lifestyle habits, such as regular exercise and eating a well-balanced diet, are essential for strengthening your bones. However, for some individuals with osteoporosis, medication may be advised to augment this effect and further protect against fractures.

    • What is the newest osteoporosis medication?

      The osteoporosis medication Evenity (romosozumab) was FDA-approved in 2019 to treat osteoporosis in postmenopausal females at high risk of breaking a bone.

    • Which osteoporosis medication is the safest?

      Osteoporosis drugs have different risks and side effects profiles. Generally speaking, a bisphosphonate, like Fosamax or Actonel, is the first choice when choosing a medication for osteoporosis.

    Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

    1. Gold T, Williams SA, Weiss RJ, et al. Impact of fractures on quality of life in patients with osteoporosis: a US cross-sectional survey. J Drug Assess. 2019;8(1):175-183. doi:10.1080/21556660.2019.1677674

    2. LeBoff MS, Greenspan SL, Insogna KL, et al. The clinician’s guide to prevention and treatment of osteoporosis. Osteoporos Int. 2022;33(10):2049-2102. doi:10.1007/s00198-021-05900-y

    3. Ji MX, Yu Q. Primary osteoporosis in postmenopausal women. Chronic Dis Transl Med. 2015;1(1):9-13. doi:10.1016/j.cdtm.2015.02.006

    4. Sözen T, Özışık L, Başaran NÇ. An overview and management of osteoporosis. Eur J Rheumatol. 2017;4(1):46-56. doi:10.5152/eurjrheum.2016.048

    5. Adler RA, El-Hajj Fuleihan G, Bauer DC, et al. Managing osteoporosis in patients on long-term bisphosphonate treatment: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2016;31(1):16-35. doi:10.1002/jbmr.2708

    6. Cummings SR, Ferrari S, Eastell R, et al. Vertebral fractures after discontinuation of denosumab: a post hoc analysis of the randomized placebo-controlled FREEDOM trial and its extension. J Bone Miner Res. 2018;33(2):190-198. doi:10.1002/jbmr.3337

    7. Food and Drug Administration. Evista labeling.

    8. Food and Drug Administration. Highlights of prescribing information: Forteo (teriparatide injection).

    9. Saag KG, Petersen J, Brandi ML, et al. Romosozumab or alendronate for fracture prevention in women with osteoporosis. N Engl J Med. 2017;377(15):1417-1427. doi:10.1056/NEJMoa1708322

    10. Hejazi ZA, Namjooyan F, Khanifar M. Complementary and alternative medicine for osteoporosis. Iran J Med Sci. 2016;41(3 Suppl):S27.

    11. National Institutes of Health Osteoporosis and Related Bone Diseases National Resource Center: Osteoporosis overview.

    12. Food and Drug Administration. FDA approves new treatment for osteoporosis in postmenopausal women at high risk of fracture.


    By Colleen Doherty, MD

     Colleen Doherty, MD, is a board-certified internist living with multiple sclerosis.

  • Proper CBD Gummies Shark Tank [REVIEWS] MUST WATCH SIDE EFFECTS FIRST?

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  • CTGL) Files Provisional Patent Application for Balancing Side Effects

    CTGL) Files Provisional Patent Application for Balancing Side Effects

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     Company also Announces the Introduction of GreenFeelsTM Product Lines

    Tel Aviv, Nov. 16, 2022 (GLOBE NEWSWIRE) — Citrine Global Corp. (OTCQB: CTGL) is pleased to announce that the Company’s subsidiary has filed a provisional patent application in the United States Patent and Trademark Office (USPTO) for “COMPOSITIONS AND METHODS FOR TREATING, AMELIORATING, ALLEVIATING, MITIGATING OR BALANCING SIDE-EFFECTS ASSOCIATED WITH THE USE OF MEDICINES, TREATMENTS, AGING, AND UNBALANCED OR UNHEALTHY LIFESTYLE”, patent No: 63/418,046.

    The patent application relates to compositions, methods and solutions for balancing side effects caused by medicinal use, medical treatments, aging and unbalanced or unhealthy lifestyle, such as dryness in the oral cavity, headaches, dizziness, drowsiness, fatigue, nausea, vomiting, lack of concentration, impaired appetite, and more. Research shows that complementary products can balance side effects associated with medicinal use or treatments. For example, probiotics, natural nutritional supplements are recommended as a complementary product to balance side effects associated with the use of antibiotics1.

    In addition, the company is happy to announce the introduction of the GreenFeelsTMproduct lines and brand.

    The GreenFeelsTM product lines include more than 100 wellness products & nutritional supplements targeting to improve the quality of life.

    The GreenFeelsTM product lines come in multiple form factors that include herbals, medicinal mushrooms, vitamins, minerals, and a variety of researched plants known for their healing qualities that contain substances with different anti-inflammatory properties and a variety of health-supportive effects that are relaxing, sleep enhancing, energizing, mood, and body balancing, enhancing oral care, alleviating side effects, and more.

    The GreenFeelsTM products lines include the following product categories:

     

    ●

    GreenFeelsTMOral Cavity Care Product Line

     

    ●

    GreenFeelsTMMedicinal Mushrooms Product Line

     

    ●

    GreenFeelsTMBooster Product Line

     

    ●

    GreenFeelsTMPersonal Protection Product Line

     

    ●

    GreenFeelsTMBalance & Calm Product Line
     

    ●

    GreenFeelsTMProduct Line for Men
     

    ●

    GreenFeelsTMProduct Line for Women
     

    ●

    GreenFeelsTMProduct Line for Sports
     

    ●

    GreenFeelsTMProduct Line for Weight Management
     

    ●

    GreenFeelsTMProduct Lines for supporting various health conditions

    The company is planning to market the product lines & brands worldwide in compliance with local regulations, focusing on the U.S. market, through building a global network with local teams and subsidiaries, partnerships and collaborations with distributors, retail and pharmacy chains, and mergers & acquisitions of distribution companies.

    About Citrine Global Corp. )CTGL( www.citrine-global.com

    Citrine Global is a plant-based wellness & pharma solutions company. The company’s business activity is primarily comprised of developing wellness and pharma solutions, focused on science backed plant-based products to improve quality of life and complementary solutions for balancing side effects caused by using medicines, treatments, or an unbalanced lifestyle.

    The company’s headquarters and senior management are based in Israel where the company operates via its 100{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}-owned-subsidiary, CTGL Citrine Global Israel Ltd., & its 60{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}-owned-subsidiary, Cannovation Center Israel Ltd. The company’s presence in Israel combined with close contacts with leading universities, researchers, companies, shareholder, and governmental support powers the company to access the latest technologies, talent, and innovation to bring innovative solutions to the global market.

    The company developed formulations and products lines that include wellness products & nutritional supplements under the Green Side by Side™ brand name and the GreenFeels™ brand name in multiple form factors that include herbals, medicinal mushrooms, vitamins, minerals, and a variety of researched plants known for their healing qualities that contain substances with different anti-inflammatory properties and a variety of health-supportive effects that are relaxing, sleep enhancing, energizing, mood and body balancing, enhancing oral care, alleviating side effects, and more.

    The company created an end-to-end strategy that covers all the infrastructure, and activities required for developing, manufacturing, marketing, sales, distribution and bringing to the global market innovative plant-based wellness and pharma products.

    The company is building the Green Vision Center, a first-of-its-kind production and innovation center providing in a single location everything required for production, innovation, and release-to-market of plant-based wellness & pharma products.

    The company’s mission is to leverage the power of plant-based solutions from nature and bring to market, on a global scale, innovative plant-based wellness and pharma solutions to help improve people’s health and quality of life.

    For more information visit our website www.citrine-global.com
    contact: [email protected]

    Safe Harbor Statement

    This press release contains express or implied forward-looking statements within the Private Securities Litigation Reform Act of 1995 and other U.S. federal securities laws. For example, Citrine Global is using forward-looking statements when it discusses that Cannovation Center Israel Ltd. will create an eco-system that will attract partners, market leaders, companies, and technologies, and will turn Cannovation Center Israel Ltd. into a global center in these fields. These forward-looking statements and their implications are based on the current expectations of the management of Citrine Global and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. Factors that could cause actual results to differ materially from those estimated by the forward-looking statements contained in this communication include but are not limited to trends in target markets; market acceptance of our product offerings, profitability of the new lines of business, effects of competition in the Company’s main markets; ability to establish and maintain strategic relationships in its major businesses, our ability to raise sufficient capital resources to realize our business plan, profitability of the growth strategy; and changes in global, political, economic, business, competitive, market and regulatory forces. Our actual results, performance, or achievements could differ materially from those expressed or implied by the forward-looking statements as a result of a number of factors, including the risks discussed under the heading “Risk Factors” discussed under the caption “Item 1A. Risk Factors” in Part I of our most recent Annual Report on Form 10-K and in our other filings with the SEC. We undertake no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise that occur after that date, except as required by law.

    1 N.A.Kerna, 2018, A complementary medicine approach to augmenting antibiotic therapy current practices in the use of probiotics during antibiotic therapy, International Journal of Complementary & Alternative Medicine.