Impact of CBD on the Pharmacokinetics of Methylphenidate

Linda Rider

With the increase of cannabidiol (CBD) use, understanding how it can influence the outcome of other medications is important.

The use of cannabidiol (CBD) for a assortment of health care reasons is growing and some persons working with CBD could also choose other medicines. Earlier in vitro investigation has indicated that CBD could potentially negatively impact selected drug-metabolizing enzymes, these kinds of as carboxylesterase 1. Methylphenidate is a person drug that utilizes that enzyme. New study examines the effect of CBD on methylphenidate.1

The investigators recruited healthier, nonsmoking grownups aged 21 to 45 years. Participants were being not authorized to use other prescription or OTC medicines, with the exceptions of oral contraceptives for woman members. Dietary supplements and emergency beverages ended up also restricted. Just about every participant experienced 2 visits where they either have been randomized to both get CBD 750 mg, presented as 7.5 mL of CBD alternative 100 mg/mL of CBD, or 7.5 mL of CBD placebo answer made up of no CBD, to be taken 2 times for each working day. The pharmacokinetic sampling stop by lasted 8 several hours wherever contributors ended up provided an indwelling venous catheter standardized lunch and breakfast and just one 10 mg of methylphenidate dose, as properly as a CBD dose that matched what they’d taken prior to the pay a visit to. Pharmacokinetics for both equally methylphenidate and CBD had been identified utilizing noncompartmental evaluation.

The study recruited 12 subjects, with 2 withdrawing as a end result of scheduling conflicts and suffering from nausea. Investigators identified that the peak concentration for the CBD and placebo group was 13.5 ± 43.7{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} ng/mL and 12.2 ± 36.4{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} ng/mL, respectively, with an area under the curve of 70.7 ± 32.5{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} for the CBD group and 63.6 ± 25.4{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} for the placebo group. When when compared with only methylphenidate, the geometric signify ratio for location less than the curve and peak focus along with administration of CBD was 1.09 (.89, 1.32) and 1.08 (.85, 1.37), respectively.

The investigators concluded that usage of a clinically related dose of CBD “led to nominal effect on the pharmacokinetics of methylphenidate.” This implies that CBD is not likely to generate a important drug-drug interaction with methylphenidate and may perhaps produce very similar effects with other medicines that utilize carboxylesterase 1.


1. Markowitz JS, De Faria L, Zhang Q, et al. The impact of cannabidiol on the pharmacokinetics of methylphenidate in nutritious subjects. Med Cannabis Cannabinoids. 20225(1):199-206. doi:10.1159/000527189

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