Right now we are asserting adjustments to COVID-19 testing amenities positioned at UMass Amherst. Next the state’s determination to downsize its Prevent the Spread screening application and conclude funding for the campus’ neighborhood tests internet site, the final working day of tests for non-UMass neighborhood members will be Thursday, March 31. The UMass Amherst testing centre, centered in the Campus Centre, will go on to provide pupils, school and staff and members of their households, as effectively as college-sponsored site visitors.
Given that the UMass Amherst Prevent the Unfold spot opened in December 2021, extra than 95,000 checks had been carried out for local community members. We want to thank all the pupil staff members, workers, supporters and local community customers who participated in the Halt the Spread plan and the Baker-Polito administration for funding this critical support.
Vaccine clinics resumed this week and are presented on Wednesdays from 10 a.m. to 1 p.m. and Thursdays from 1 to 4 p.m. till April 30. Walk-ins will be acknowledged, but we encourage anyone to ebook an appointment.
We continue on to observe COVID-19 tendencies in our neighborhood through our symptomatic, adaptive and voluntary tests method as properly as wastewater surveillance. The hottest COVID-19 tests facts for the UMass community for March 16-22 exhibits 39 new beneficial cases. Persons screening beneficial continue to report they are going through nominal to reasonable signs or symptoms of infection and there are no hospitalizations to report. The university’s positivity charge is 2.30{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, in contrast to past week’s fee of 1.83{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}. The state’s 7-day positivity rate is 1.91{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}.
Make sure you proceed to keep track of oneself for COVID-19 signs and symptoms every working day prior to coming to campus. If you really feel unwell, remain household and get examined. College Wellness Expert services has symptomatic screening available for learners, or, if you have an unobserved exam package on hand you can fall it off at just one of the campus kiosks.
KN95 masks continue to be accessible for totally free at the Public Health Advertising Centre (PHPC) in the Campus Middle, and as a community we motivate all people to respect the selections that individuals will make about their own masking.
Thank you for all that you are doing — keeping residence when sick, screening when you have signs, and supporting each and every other as section of our community.
Sincerely,
Co-Administrators of the General public Overall health Advertising Centre (PHPC)
Ann Becker, General public Overall health Director Jeffrey Hescock, Govt Director of Environmental Health and Protection
The Tompkins County Wellness Office says there have now been 18,445 total positive cases in Tompkins County, 87 a lot more than on Wednesday, and a total of 1,851,106 exams executed. The Health and fitness Office is also now reporting optimistic self-test success that have been submitted via their on line portal. They say there are 10 new beneficial self-test effects for a overall of 1,874 submitted.
Linked: TCHD: If you examination constructive on an at-household test
As of Thursday at 8:10am, the Wellbeing Division states 1,330 tests had been performed in the past working day. The Tompkins County Health and fitness Division publishes NYS vaccine monitoring data, displaying 84,162 Tompkins County inhabitants have a first dose and 76,765 have completed vaccination (which could be a single or two doses, based on vaccine), Business Law.
Connected: Cornell returns its COVID-19 notify stage to Yellow
The Well being Office claims no a person is at the moment hospitalized for COVID-19, a person less than in Wednesday’s update. As of a change in facts past wintertime, “TCHD is reporting only energetic conditions who are hospitalized,” fairly than including individuals recovered from COVID who remain hospitalized for other reasons.
There have been 59 deaths from COVID-19 recorded amongst Tompkins County residents, such as the dying of two location people reported very last month.
On March 23, Cornell College documented 151 new optimistic instances for March 22, 163 energetic university student conditions, and 36 energetic staff circumstances. Cornell only updates its dashboard on weekdays, and the timing of their updates does not allow for a immediate comparison to the county’s figures.
As of March 17, Ithaca University noted 4 energetic college student circumstances, with 456 recovered, and one energetic employee case and 163 recovered personnel, Business Law.
The Wellbeing Section says its figures involve testing that Cornell College began conducting on July 16, 2020. Cornell introduced its very own COVID-19 facts dashboard on August 25, 2020.
Related: New Cornell COVID-19 dashboard displays take a look at success and notify amount
The Overall health Office states the general public wants to prevent the spread of COVID-19 not just to shield by themselves, but other individuals in our neighborhood who are most susceptible to receiving extremely unwell – older older people, all those who are immune-compromised, and individuals with fundamental continual well being circumstances.
TCHD’s Frank Kruppa states, “There is a quite substantial vaccination fee for our group, primarily with the successes that have been noted by our nearby colleges. In addition to the arrival and surveillance tests, numerous of our new situations are arising from sustained near contact with a good unique, this means extra than 10 minutes in just 6 ft of a good case. These shut contacts are occurring much more commonly in large indoor gatherings that combine various groups of men and women, Business Law.”
Related: As Tompkins County drops to “low” COVID stage, Health Office suspends mask advisory
“According to the metrics just lately introduced by the CDC concerning ‘community stages,’ Tompkins County has fallen into the “Low” group based on the subsequent data: less than 200 new conditions per 100,000 people today about the previous 7 days, considerably less than ten new COVID-19 admissions per 100,000 persons at Cayuga Health care Middle, and decreased than 10 percent of staffed inpatient beds at the hospital occupied by COVID-19 clients,” the Overall health Department states.
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Relevant: Coronavirus coverage in 14850 These days
For monoclonal antibody therapy, a lab creates antibodies, the body’s way of fighting infections, specific to the coronavirus. The dose, given as an infusion, creates “temporary, enhanced immunity, which can help avoid progressing to more severe symptoms,” according to HHS.
What are the specific therapeutics currently available?
Antivirals:
Two oral antiviral medications are available in the United States: Paxlovid and Molnipiravir.
Paxlovid is available for patients to take at home and “had an 89{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} reduction in the risk of hospitalization and death in clinical trials,” according to Yale Medicine. Patients take three pills twice daily for five days, and it requires a prescription. The drugs should be taken as soon as possible after a positive test and within five days of symptom onset, according to the U.S. Food and Drug Administration.
Paxlovid contains two drugs: “Nirmatrelvir prevents key proteins that the virus needs to make more copies of itself from functioning properly. It’s taken in combination with ritonavir, which helps keep nirmatrelvir from being broken down before it has completed its job,” according to Houston Methodist Hospital.
Molnupiravir, made by Merck, consists of four pills every 12 hours for five days. “Molnupiravir works by introducing mistakes into the virus’s genetic code, preventing the virus from replicating properly,” according to Houston Methodist Hospital.
The antiviral drug is only recommended by National Institutes of Health officials if other drugs are not readily available because Molnupiravir is not as effective as some other therapeutics. Trials showed it reduced the rate of hospitalization or death by 30{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}.
A third antiviral drug, Remdesivir, is available as a once-a-day infusion for three to five days. The drug prevents the virus from multiplying by “interfering with one of the key enzymes the virus needs to replicate RNA,” according to the National Institutes of Health. While it is used in hospitalized cases, it is also available for patients who are not hospitalized but who are at high risk for progression to severe disease.
Monoclonal Antibodies:
Three monoclonal antibody treatments are available in the United States: Bebtelovimab, Sotrovimab and Evusheld.
Sotrovimab is given as a one-time intravenous infusion, while Bebtelovimab is given as a one-time injection. Both should be administered within seven days of symptom onset. Patients must go to a provider or infusion clinic to receive the monoclonal antibodies.
In clinical trials, Sotorvimab showed a 79{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} reduction in hospitalizations and deaths, according to the NIH. Bebtelovimab is the newest monoclonal antibody treatment to receive authorization, with the FDA signing off in February.
Immunocompromised patients may consider Evusheld, a two-shot monoclonal antibody treatment given prophylactically to people who are moderately to severely immunocompromised or who may not be eligible for the vaccine (if, for example, they are allergic to a component of the vaccine).
How are these drugs regulated? Are they FDA approved?
The only drug approved by the Food and Drug Administration for use against COVID-19 is Remdesivir, according to the National Institutes of Health.
Other drugs, such as Paxlovid, Sotrovimab, Molnupiravir, Bebtelovimab and Evusheld have received emergency use authorization so they may be used in certain circumstances for nonhospitalized patients with COVID-19. Emergency use authorization is a special process for expedited use of therapeutics in an emergency when certain conditions are met, including a lack of alternative treatments.
How effective are these treatments against the latest variants?
Scientists are still assessing the effectiveness of these treatments against the latest variant, omicron BA.2. In the Southern region of the United States, which includes Alabama, Florida, Georgia, Kentucky, North Carolina, Mississippi, South Carolina and Tennessee, the latest CDC data showed omicron BA.2 accounting for about 21{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} of total cases.
The antiviral drugs appear to work against the latest variant, while monoclonal antibodies are less effective, according to The New York Times.
Sotrovimab was shown to effectively combat the original omicron variant, but early research shows a decline in its efficacy against omicron BA.2, according to the journal Nature. The company that developed Sotrovimab issued a statement saying research indicates Sotrovimab “is sufficient to retain activity against the BA.2 variant” and promising more data in support of the drug soon.
Bebtelovimab is recommended by federal officials only when other treatments are not available or clinically appropriate.
A recent study showed Evusheld was the “most effective antibody treatment against the BA.2 variant.”
Who qualifies for these treatments?
For any of the antiviral drugs or monoclonal antibody treatments, a patient must be at high risk for progression to severe disease.
People who are elderly, smokers, pregnant, nursing home residents or people who have certain health conditions are considered high risk. A list of risk factors from the N.C. Department of Health and Human Services is here.
Paxlovid is available to patients 12 and older who weigh at least 88 pounds. Patients must be 18 or older to take Molnupiravir. The FDA does not recommend Molnupiravir for pregnant women.
People on certain medications, specifically those that inhibit or induce CYP3A, may need to adjust the timing and dosage if they are taking Paxlovid, federal officials warn. Individuals should tell their provider about any other medications or supplements they take before starting Paxlovid.
Remdesivir is FDA-approved for patients 12 and older who weigh at least 40 kg (88 lbs.). For pediatric patients under 12 who weigh at least 3.5 kg (7.7 lbs.), Remdesivir may be given under an Emergency Use Authorization if certain kidney-related tests are adequate.
Monoclonal antibody treatments Sotovimab and Bebtelovimab are available to patients who are at least 12 years old and weigh at least 40 kg (88 lbs). Sotovimab is not permitted for patients who are on oxygen because of COVID-19 or for patients who are on oxygen for a chronic condition and have had to increase oxygen due to COVID-19.
Evusheld is available to anyone 12 or older who weighs at least 40kg (88 lbs) who is moderately or severely immunocompromised or who are not recommended to receive a vaccine. Patients who opt to get Evusheld following a vaccine should wait at least two weeks after their vaccination.
How does one obtain these therapeutics?
All of the treatments require a positive result from a direct virus test. Antiviral oral drugs Paxlovid and Molnupiravir require a prescription.
Through a new federal government initiative, the Test of Treat program, “people who test positive for COVID-19 will be able to visit hundreds of local pharmacy-based clinics and federally-qualified community health centers (FHQCs), and residents of long-term care facilities will in one stop, be assessed by a qualified health care provider who can prescribe antiviral pills on the spot,” according to the U.S. Department of Health and Human Services.
Paxlovid and Molnupiravir will be available. Patients who test positive on a home test may also bring their test to the site to receive the drugs.
Patients who need Remdesivir or one of the monoclonal antibody treatments should go to a clinic or hospital. Find a treatment site through the searchable list provided by the North Carolina Department of Health and Human Services.
Evulsheld requires a prescription and is available in limited quantities at providers across the state.
How much do they cost?
Because the federal government purchased therapeutics from drug manufacturers and provided them to health care providers, patients may receive these medications for free.
Paxlovid, Molnupiravir, Bebtelovimab and Sotovimab are available without cost to the patient. Patients may incur expense related to the administration of monoclonal antibodies depending on provider.
Remdesivir is sold at $390 per vial or $2,340 for a 5-day regimen, while private insurance companies in the United States pay $520 per vial and $3,120 for a 5-day regimen, according to NPR. Patient costs will vary by insurance plan, and patients may incur a copay or other fee for the infusion appointment and process, NPR notes.
Evusheld is available through Medicare for about $150. For in-home administration to Medicare patients and in other specific circumstances, the injection costs about $250. For patients with private insurance, the cost may vary.
Are these treatments readily available in North Carolina?
Therapeutics for COVID-19 are allocated to states on a weekly basis.
For the week of March 21, North Carolina received 3,120 units of Paxlovid, 985 units of Bebtelovimab, 1,248 units of Molnupiravir, and 1,134 units of Sotovimab.
Are these treatments a substitute for vaccination?
No. Vaccines remain the best protection against COVID-19, according to federal and state public health officials.
As with any medical treatment, the therapeutics come with risks and side effects. Because the drugs are most effective early in infection, people who rely solely on treatments run the risk of their illness becoming severe before they seek treatment, Reuters reported.
North Carolinians are currently faced with choices and confusion about which personal protective measures they should take against COVID-19, as Gov. Roy Cooper released guidance encouraging schools to make masks optional starting March 7 and the state’s remaining counties with mask mandates ended them.
These changes follow a drop in cases across the state, as the Omicron surge appears to be on its way down, but they have left North Carolinians with questions: To mask or not to mask? Stock up on COVID tests? Is COVID over?
Experts are even unsure, as the pandemic enters yet another new phase.
North Carolina saw a sharp decrease in COVID cases following the surge of the highly transmissible Omicron variant across the world in December and January.
At the height of the Omicron surge, the North Carolina Department of Health and Human Services reported almost 45,000 COVID cases, dwarfing previous surges. That number is now down to fewer than 2,000 daily cases.
Some public health experts, such as Anthony Fauci, President Joe Biden’s top adviser on the pandemic predict an “uptick” of COVID cases as a result of the BA.2 subvariant of the Omicron variant, which is causing an increase of cases in Europe.
U.S. Surgeon General Vivek Murthy urged Americans to remain prepared for whatever COVID has in store, in an interview on “Fox News Sunday.”
“We’re in that mile 18 of a marathon,” Murthy said. “We can’t quit, because COVID’s not quitting.”
North Carolina DHHS Sec. Kody Kinsley said North Carolina tends to be six weeks behind COVID trends in Europe, during a press conference on March 17.
Though cases are rising in some European countries, in the past month, travel restrictions have started to ease throughout most European nations.
The United Kingdom, France, Greece, Romania and other nations have begun lifting requirements for entry such as passenger locator forms, COVID-19 entry restrictions, and proof of vaccination.
However, most countries in the European Union enforce policies regarding the use of facemasks while indoors or using public transit.
Loosen up?
While cases are low, John Wiesman, professor of the practice in the Department of Health Policy and Management at the UNC Gillings School of Global Public Health, said North Carolinians should enjoy this time.
“We are at a place where community transmission is much lower,” Wiesman said. “And we do have this pent-up demand to want to do things we haven’t been doing, whether it’s going to the movie theater, whether it’s doing some traveling, whether it’s seeing people in our family who we haven’t seen for a long time.”
That doesn’t mean COVID is over though, Wiesman said.
Thomas Holland, associate professor of Medicine at Duke University School of Medicine, hearkened back to the first COVID curveball, the Delta variant.
“Last summer when we had really low case counts,” Holland said, “and around June, July time, I felt pretty confident that we wouldn’t see another big surge until the winter — sort of traditional respiratory virus season, and that was wrong, right? Delta arrived around that time, and then we had a big surge even during the warm summer months.”
Even as North Carolinians enjoy this time, Wiesman said, they shouldn’t let their guard down.
“I think the keyword here is we just need to remain vigilant,” Wiesman said.
Remaining vigilant
Wiesman recommended consulting the Centers for Disease Control and Prevention (CDC) community-level transmission data to assess your risk. Wastewater data is also one way to detect COVID transmission early, Wiesman said. North Carolina Health News previously reported on how wastewater works as an early detection tool.
It’s not just up to individuals to remain vigilant, Wiesman said, but also governments.
“We need to make sure that our public health systems have the resources they need to track these variants and viruses,” Wiesman said.
A key part of that vigilance is for Congress to pass the supplemental pandemic funding that has been stalled in Washington. Biden asked Congress for $22.5 billion in his National COVID-19 Preparedness Plan, but so far that package has received pushback on both sides of the aisle.
Gov. Cooper, DHHS’s Kinsley and other North Carolina officials urged the importance of continued federal aid at a press conference on Thursday, North Carolina Health News previously reported.
“I am most concerned about our supply of testing in the private markets and the unique ability of the federal government to maintain those levels of supply by pushing and propping up that market,” Kinsley said Thursday. “So I hope we will see that funding come. We need it to stay prepared. It’s not the time to take a step back.”
Federal funding would help provide for some of the newer tools to fight against COVID, including the new antiviral medication Paxlovid, which has been shown to dramatically reduce the risk of hospitalization if taken early in a COVID infection and the long-acting antibody combination, Evusheld, which can be used for pre-exposure prevention against COVID. For months, supplies had been limited, but now doses of the drug are sitting on pharmacy shelves and in federal stockpiles.
There are things that individuals can do to prepare for whatever curveball COVID might throw next.
Taking action now
Wiesman encouraged taking this time to get vaccinated or boosted if you have not yet.
It’s also a good time to have some rapid tests at home. President Joe Biden announced earlier this month that people can order four more free rapid tests after rolling out the initial program in January. Insurers are now required to reimburse for the purchase of as many as eight rapid tests per month.
Especially as pollen season starts in North Carolina, using a rapid test can help determine if that runny nose is the result of the yellow stuff floating in the air or if you have a runny nose because you’ve caught COVID. Rapid tests are especially important if you want to spend time indoors or in close proximity to someone who is at risk of a bad outcome if they catch the virus.
You can also take action to help yourself and others by having a mask handy, Holland said.
“The places that I still wear a mask are the places where I don’t really know the vaccination status of the people around me,” Holland said. “Like going in the grocery store. Or in stores. I still mask up for that whether it’s required or not.”
Just because mask guidelines have loosened up for now does not mean that masks don’t work, Holland said. A well-fitting mask — such as an N95 or a KN 94 — helps to reduce transmission of the coronavirus.
In some cities in Europe, such as Madrid, Spain, the use of facemasks is mandatory for individuals both indoors and outdoors where distancing can not be maintained.
People wear masks when walking outside, on the subway, in classrooms, at work and sometimes even in cars. COVID testing sites are also widely available, and pharmacies carry take-home tests that cost the equivalent of about $6 to $8.
Though the vaccination rate has hit 85 percent in Spain, with 87 percent of people having at least one dose, lawmakers are still enforcing safety measures, and individuals are still taking precautions to ensure health and safety.
If cases start to pick up again in the U.S. like they are in Europe, Holland said it would make sense to mask up again and limit travel and interactions.
“We are still in an uncertain time,” Wiesman said. ”Just be aware of that.”
This article was updated to clarify that Gov. Cooper encouraged schools to lift their mask mandates.
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by Elizabeth Thompson, North Carolina Health News March 22, 2022
SHIJIAZHUANG, China, March 21, 2022 /PRNewswire/ — On March 19, the Media Briefing on Prevention and Command of COVID-19 with Lianhua Qingwen Capsules, a patented Chinese drugs designed and manufactured by Yiling Pharmaceutical, was convened in Shijiazhuang Town, Hebei Province, at which the in vitro experimental success of Lianhua Qingwen Capsules versus SARS-CoV-2 Omicron variant by Guangzhou Institute of Respiratory Health not too long ago were being posted. These experimental final results present that Lianhua Qingwen Capsules have considerable inhibiting result on the cytopathic effect induced by Omicron variant so as to reach the anti-novel coronavirus influence.
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The analysis benefits of “Efficacy and Basic safety of Lianhuaqingwen Capsules for the Avoidance of Coronavirus Disorder 2019: A Potential Open-Label Controlled Trial” released on the Evidence-centered Complementary and Different Medicine present that Lianhua Qingwen Capsules can significantly cut down the infection rate of shut contacts and the incidence rate of indicators for clients who are favourable in nucleic acid take a look at, specially the incidence fee of fever, so as to give new therapeutic regimens for suspected scenarios and near contacts of COVID-19.
In the Prognosis and Treatment Protocol for COVID-19 (Trial Model 9) released by Chinese federal government on March 14, Lianhua Qingwen Capsules are advised for prevention and command of the inhabitants beneath clinical observation and delicate and normal clients in the course of scientific remedy. Lianhua Qingwen Capsules have been recommended for procedure of COVID-19 for 6 moments in the nationwide protocol considering that the outbreak of COVID-19.
The Tompkins County Health Department states there have now been 18,254 complete constructive instances in Tompkins County, 44 a lot more than on Friday, and a total of 1,847,554 exams performed. The Overall health Section is also now reporting good self-take a look at results that have been submitted by way of their on the net portal. They say there are 32 new positive self-examination benefits for a full of 1,833 submitted.
Linked: TCHD: If you check beneficial on an at-residence check
As of Monday at 8am, the Wellness Office says 284 tests were being executed in the preceding day. The Tompkins County Wellness Section publishes NYS vaccine monitoring facts, exhibiting 84,132 Tompkins County residents have a to start with dose and 76,747 have done vaccination (which could be a single or two doses, relying on vaccine).
The Health Office says no one particular is now hospitalized for COVID-19, one particular less than in Friday’s update. As of a shift in info last wintertime, “TCHD is reporting only lively situations who are hospitalized,” rather than including clients recovered from COVID who continue being hospitalized for other reasons.
There have been 59 deaths from COVID-19 recorded amongst Tompkins County residents, which includes the dying of two space inhabitants reported past month.
On March 18, Cornell University reported 33 new optimistic conditions for March 17, 103 energetic college student situations, and 19 energetic worker circumstances. Cornell only updates its dashboard on weekdays, and the timing of their updates does not enable a immediate comparison to the county’s studies.
As of March 17, Ithaca School documented 4 energetic scholar circumstances, with 456 recovered, and just one lively staff circumstance and 163 recovered staff.
The Well being Department suggests its studies consist of screening that Cornell University started conducting on July 16, 2020. Cornell introduced its personal COVID-19 info dashboard on August 25, 2020.
Linked: New Cornell COVID-19 dashboard demonstrates examination success and warn degree
The Health and fitness Department claims the public wants to avert the spread of COVID-19 not just to safeguard them selves, but some others in our local community who are most vulnerable to receiving quite sick – older grownups, these who are immune-compromised, and all those with fundamental serious health situations.
TCHD’s Frank Kruppa claims, “There is a very superior vaccination level for our community, in particular with the successes that have been described by our area schools. In addition to the arrival and surveillance screening, a lot of of our new instances are arising from sustained shut make contact with with a constructive particular person, which means extra than 10 minutes within six toes of a optimistic case. These near contacts are transpiring more regularly in big indoor gatherings that combine various groups of persons.”
Similar: As Tompkins County drops to “low” COVID stage, Wellbeing Office suspends mask advisory
“According to the metrics recently produced by the CDC with regards to ‘community degrees,’ Tompkins County has fallen into the “Low” class based on the pursuing info: much less than 200 new circumstances for every 100,000 people about the previous seven times, less than 10 new COVID-19 admissions for every 100,000 people today at Cayuga Professional medical Centre, and lessen than 10 {fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} of staffed inpatient beds at the healthcare facility occupied by COVID-19 sufferers,” the Well being Section claims.
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