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15 Best CBD pills in 2022

CBD oil is becoming more and more popular as a means to treat various medical conditions. CBD, or cannabidiol, is a compound found in cannabis that has been shown to be effective in treating everything from anxiety to chronic pain. In this blog post, we will take a look at the 15 best CBD pills on the market in 2022.

Penguin CBD Capsules
Everest Full Spectrum Gummies
Planet Delta Gummies
Medterra Isolate CBD Gel Capsules
Joy Organics Premium CBD Softgels
Lazarus Naturals Full Spectrum CBD Softgels
Bluebird Botanicals Classic Concentrated CBD Soft Gels
Sunsoil CBD Oil Vegan Capsules
Charlotte’s Web CBD Oil Liquid Capsules
CBDistillery Relief + Relax CBD Softgels
Green Roads CBD Softgels
Cornbread Hemp Full Spectrum CBD Capsules
R+R Medicinals CBD Softgels
Prima Sleep Tight CBD Softgels
NuLeaf Naturals Full Spectrum CBD Capsules

What is CBD?

CBD, or cannabidiol, is a compound found in cannabis that has been shown to be effective in treating various medical conditions. CBD is non-psychoactive, meaning it will not get you high.

CBD is thought to work by interacting with the body’s endocannabinoid system, which helps to regulate things like sleep, appetite, and pain.

What are CBD pills?

CBD pills are capsules that contain CBD oil. They are a convenient and easy way to take CBD, and they can be used to treat a variety of medical conditions.

How do CBD pills work?

CBD pills work by interacting with the body’s endocannabinoid system. This system is responsible for regulating things like sleep, appetite, and pain. By interacting with this system, CBD is thought to provide relief from various medical conditions.

What are the benefits of CBD?

CBD has been shown to be effective in treating a variety of medical conditions, including:

Anxiety
Depression
Chronic pain
Epilepsy
Insomnia

How do I take CBD?

CBD is available in a variety of forms, including:

Capsules

CBD capsules are a convenient way to take CBD. They are easy to use and can be taken with or without food. CBD capsules provide a slow and steady release of CBD, which makes them a good choice for those who want sustained relief from their medical condition.

Oils

CBD oils can be taken in a variety of ways, including orally, sublingually, or topically. CBD oils are available in a variety of flavors, making them easy to use. CBD oils are also available in a variety of strengths, making them a good choice for those who need high doses of CBD.

Gummies

CBD gummies are a convenient and easy way to take CBD. They can be taken with or without food, and they come in a variety of flavors. CBD gummies provide a slow and steady release of CBD, which makes them a good choice for those who want sustained relief from their medical condition.

Topicals

CBD can be applied topically to the skin in the form of a cream, lotion, or balm. CBD topicals are thought to provide relief from a variety of conditions, including:

Arthritis
Inflammation
Muscle pain
Sleep disorders

It is important to start with a low dose and increase gradually as needed. It is also important to talk to your doctor before taking CBD, as it can interact with certain medications.

Tips for Choosing the 15 Best CBD Pills in 2022

The cannabidiol (CBD) market is expected to be worth $22 billion by 2022. CBD products are available in many forms, including pills.

Pills offer a convenient way to take CBD, as they can be taken with or without food and water. The best CBD pills in 2022 are also an excellent way to get the proper dose of CBD each time.

Check for 3rd Party Lab Tests

When looking for the best CBD pills in 2022, it is important to check for 3rd-party lab tests. This will ensure that you are getting a product that is high quality and safe.

The lab tests should also be able to tell you the amount of CBD in each pill. This information is important, as it will help you determine the proper dose for your needs.

Look for a Reputable Brand

Another important factor to consider when choosing the best CBD pills in 2022 is the reputation of the brand. A reputable brand will use high-quality ingredients and manufacturing processes.

They will also be transparent about their products, providing clear labeling and customer service.

Check Potency

The potency of a CBD pill is important, as it will help you determine the correct dose. A high-potency CBD pill will contain a higher amount of CBD than a low-potency pill.

This information is important, as it will help you find the right dosage for your needs. Start with a low-potency pill and increase the dose as needed.

Check Customer Reviews

When looking for the best CBD pills in 2022, it is important to check for customer reviews. This will help you get a sense of what others think about the product.

Customer reviews can provide valuable information, such as the potency of the CBD pill, the quality of the ingredients, and the overall satisfaction with the product.

Is CBD Legal?

CBD is legal in many countries, including the United States. However, the legality of CBD can vary from country to country. It is important to check the laws in your country before purchasing CBD pills.

What are the different types of CBD pills?

CBD pills are available in many different forms. Below you’ll find the two most common types of CBD pills:

Oil-Based Pill

Oil-based CBD pills are made from hemp oil. Hemp oil is a natural extract of the cannabis plant that is high in CBD. It is a popular choice for CBD pills, as it is easy to absorb and has a mild taste.

Some people find that hemp oil-based CBD pills cause nausea or stomach discomfort. If this is the case, it is best to choose a different type of CBD pill.

Water-Soluble Pill

Water-soluble CBD pills are made with nanoemulsion technology. This technology breaks down the CBD molecules into small particles that are easier for your body to absorb.

Water-soluble CBD pills are a good choice for people who have trouble absorbing oil-based pills. They are also less likely to cause stomach discomfort.

What are the red flags to watch for with CBD pills in 2022?

When looking for CBD pills in 2022, be sure to avoid products that make claims that seem too good to be true. Be wary of products that claim to be a “miracle cure” for all ailments, as well as those that are priced significantly lower than other brands on the market.

It’s also important to do your research and make sure that the brand you’re considering is reputable. A good way to do this is to look for reviews from other customers, as well as information on the company’s website about their manufacturing process and quality control measures.

When it comes to taking CBD pills, it’s also important to start with a low dose and increase gradually as needed. This will help you to avoid any potential side effects, such as fatigue or upset stomach.

If you’re looking for CBD pills in 2022, be sure to keep these red flags in mind! With a little research, you can find a quality product that meets your needs and budget.

(Penguin) | CBD Capsules.

Cannabidiol, or CBD, is a type of cannabinoid. It’s one of the primary components in Cannabis Sativa plants, especially those classified as hemp. Hemp differs from marijuana because it has less THC and more CBD.

CBD is different from THC in important ways. It does not cause a “high” or psychoactive response, for one thing. CBD is consumed by your endocannabinoid system (ECS). The ECS has receptors throughout all of the body’s various organs and collaborates with them on basic functions.

(Everest) | Full Spectrum Gummies.

These amazing gummies are made by a US firm that is committed to excellence. Each jar contains CBD and THC in equal amounts, as well as a little amount of the latter. Take one of these gummies, let the components work their magic, and you’ll be feeling relaxed in no time! You will be ready to face whatever life throws at you.

(Planet) | Delta Gummies.

Vegan, non-GMO, Delta 8-infused gummies are made with the world’s finest USA-grown natural hemp and come from us. Each gummy contains 20mg of Delta 8 THC, for a total of 30 gummies per jar in many different varieties.

4. Medterra Isolate CBD Gel Capsules

(Medterra) | Isolate CBD Gel Capsules.

Made with 99{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} pure CBD isolate, these gel capsules are THC-free and a great option for those who want the benefits of CBD without any psychoactive effects. They’re also flavorless and easy to take, making them a popular choice for those who don’t enjoy the taste of other CBD products.

5. Joy Organics Premium CBD Softgels

(Joy Organics) | Premium CBD Softgels.

These softgels are made with a water-soluble nanoemulsion technology that increases bioavailability and makes them easier for your body to absorb. They’re also THC-free, so you don’t have to worry about any psychoactive effects.

Joy Organics is a family-owned company committed to providing premium CBD products that are third-party lab tested for quality and purity.

6. Lazarus Naturals Full Spectrum CBD Softgels

(Lazarus Naturals) | Full Spectrum CBD Softgels.

Lazarus Naturals is a trusted name in the CBD industry, and their full spectrum CBD softgels are no exception. These softgels are made with hemp that is grown and extracted in-house, so you can be sure of its quality. They’re also third-party lab tested for potency and purity.

7. Bluebird Botanicals Classic Concentrated CBD Soft Gels

(Bluebird Botanicals) | Classic Concentrated CBD Soft Gels.

If you’re looking for a high-potency option, these concentrated CBD softgels from Bluebird Botanicals are a great choice. Each gel capsule contains 25mg of CBD, making them one of the most potent options on this list.

Bluebird Botanicals is a Colorado-based company that is committed to providing high-quality CBD products.

8. Sunsoil CBD Oil Vegan Capsules

(Sunsoil) | CBD Oil Vegan Capsules.

These vegan capsules are made with CBD oil that is derived from USDA-certified organic hemp. The capsules are also gluten-free, non-GMO, and contain no artificial flavors or preservatives.

Sunsoil is a Vermont-based company that is committed to providing quality CBD products at an affordable price.

9. Charlotte’s Web CBD Oil Liquid Capsules

(Charlotte’s Web) | CBD Oil Liquid Capsules.

These CBD capsules are made with full-spectrum hemp extract and contain a wide variety of beneficial cannabinoids and terpenes. They’re also gluten-free, non-GMO, and 100{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} vegetarian.

Charlotte’s Web is a Colorado-based company that is known for its high-quality CBD products.

10. CBDistillery Relief + Relax CBD Softgels

(CBDistillery) | Relief + Relax CBD Softgels.

These softgels are made with full-spectrum CBD oil and contain a blend of essential oils and herbs that help to promote relaxation. They’re also non-GMO, gluten-free, and vegan.

CBDistillery is a Colorado-based company that is committed to providing high-quality CBD products at an affordable price.

11. Green Roads CBD Softgels

(Green Roads) | CBD Softgels.

These softgels are made with CBD oil that is derived from US-grown hemp. They’re also non-GMO, gluten-free, and vegan.

Green Roads is a Florida-based company that is committed to providing quality CBD products.

12. Cornbread Hemp Full Spectrum CBD Capsules

(Cornbread) | Hemp Full Spectrum CBD Capsules.

These vegan capsules are made with full-spectrum CBD oil that is derived from US-grown hemp. They’re also non-GMO, gluten-free, and 100{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} organic.

Cornbread Hemp is a Kentucky-based company that is committed to providing quality CBD products.

13. R+R Medicinals CBD Softgels

(R+R Medicinals) | CBD Softgels.

These softgels are made with CBD oil that is derived from US-grown hemp. They’re also non-GMO, gluten-free, and vegan.

R+R Medicinals is a Colorado-based company that is committed to providing quality CBD products.

14. Prima Sleep Tight CBD Softgels

(Prima) | Sleep Tight CBD Softgels.

Our effective combinations of clinically proven botanicals and broad-spectrum organic CBD can help you sleep better, naturally.

CBD, amino acid compounds 5-HTP and GABA, and relaxing herbs are included in this melatonin-free doctor-designed combination to assist you sleep properly and wake up rejuvenated. It’s intended to be taken every night.

15. NuLeaf Naturals Full Spectrum CBD Capsules

(NuLeaf Naturals) | Full Spectrum CBD Capsules.

CBD oil is a whole-plant extract that contains a comprehensive range of naturally occurring synergistic cannabinoids and terpenes. A convenient, plant-based softgel now available. Each tablet is precisely dosed at 15mg.

Our proprietary genetics allow us to directly create a whole plant CBD extract that is extremely concentrated in CBD and includes significant amounts of secondary cannabinoids like CBC, CBG, CBN, and more.

Cannabinoids work together and are more potent when they are combined rather than when they are taken alone. The entourage effect is the term given to this phenomenon.

What is the entourage effect?

The entourage effect is a phenomenon that occurs when different cannabinoids and terpenes work together to produce an enhanced effect. This is why many people believe that full-spectrum CBD products are more effective than CBD isolate products.

What will CBD pills in 2022 help me with?

As noted above, CBD pills can help with a wide variety of issues, including anxiety, pain, inflammation, and sleep troubles. CBD is a versatile compound that can be used to address many different ailments. As more research is conducted on CBD, we will likely see even more potential uses for it in the future.

For now, CBD pills are a safe and effective way to help with many different issues. If you are considering trying CBD, be sure to talk to your doctor first to make sure it is right for you.

Will CBD pills get me high?

No, CBD pills will not get you high. CBD is a non-intoxicating compound that will not produce any psychoactive effects. You can feel confident taking CBD without having to worry about becoming impaired or intoxicated.

How often should I take CBD pills?

The frequency with which you take CBD pills will depend on the reason you are taking them. For example, if you are taking CBD for pain relief, you may only need to take it once or twice a day. If you are taking CBD for anxiety, you may need to take it more frequently.

It is always best to start with the lowest possible dose and increase as needed. Be sure to talk to your doctor about the best dosing schedule for your individual needs.

What are the side effects of CBD pills?

CBD is generally well-tolerated with few reported side effects. The most common side effects include tiredness, diarrhea, and changes in appetite. If you experience any adverse effects, be sure to talk to your doctor.

CBD is a safe and effective way to help with many different issues. If you are considering trying CBD, be sure to talk to your doctor first to make sure it is right for you.

What is better CBD oils or CBD pills?

There is no definitive answer to this question as it will depend on each individual’s needs and preferences. Some people may prefer CBD oils because they are more versatile and can be used in different ways. Others may prefer CBD pills because they are easy to take and have a consistent dose.

CBD hemp oils are one of the most popular CBD products. They’re typically dispensed in a bottle with a dropper, which you use to squeeze the oil directly under your tongue.

The advantages of CBD oil over CBD pills and capsules are that they’re more powerful, easier to absorb, and offer a longer duration of action than hemp-derived products. On the other hand, CBD softgels are designed in a similar way as traditional softgels. You swallow them just like any other tablet.

Capsules are sometimes preferred over oils because they’re pre-dosed and have no taste. CBD oils can be flavored, but if they aren’t flavored, they might have an earthy flavor.

When it comes to cannabinoids, capsules may take longer to work. This is because capsules are subjected to the “first pass effect,” which means that after you swallow them, they are broken down in your digestive system and liver.

How long before I see results from CBD pills?

This is a question that we get a lot. And unfortunately, there’s no easy answer. Just like with most supplements, it can take some trial and error to figure out what works best for you and your body. However, we can give you some general guidelines.

For most people, it takes around two to three weeks of regular use to start seeing results from CBD pills. Of course, this varies depending on the person’s individual biochemistry, the severity of their condition, and the dosage they are taking.

If you’re new to CBD pills, we recommend starting with a lower dosage (25mg or less) and gradually increasing it until you find what works for you.

If you don’t see any results after a few weeks, you may want to try increasing your dosage or trying a different product altogether. There are a lot of different CBD products on the market, so it’s definitely worth doing some research to find one that works best for you.

Final Thoughts on 15 Best CBD Pills in 2022

CBD pills are a great way to get your daily dose of CBD, but it’s important to remember that they’re not a miracle cure-all. Just like with any supplement, it takes time to see results, and everyone is different.

We’ve featured the best CBD pills in 2022 to take here today so that you have a variety of options to choose from. Our list includes both full-spectrum and isolate CBD pills, so you can find the one that’s right for you.

Do your research and start with a lower dosage, and you’re sure to find the perfect CBD pill for your needs. As always, be sure to speak with a doctor before starting any new supplement regimen. This is especially important if you’re taking any other medications.

April 23, 2022

How To Increase Serotonin: Foods, Pills, Natural Tips

Serotonin is a neurotransmitter (brain chemical) that works to stabilize mood and foster feelings of happiness and well-being. It also plays a role in how well the brain and nervous system cells communicate, enhances focus, and helps regulate the digestive system and sleep cycle.

The body naturally produces serotonin using the essential amino acid tryptophan. While the body can make serotonin on its own, sometimes it doesn’t make enough to keep the brain and other systems functioning optimally. If serotonin levels are low, your risk of depression and anxiety increases and other problems can occur.

This article will discuss the importance of adequate serotonin levels in the body, as well as how to boost serotonin both naturally with the help of food, sunlight, and exercise, and synthetically through medications and supplements.

Drazen_ / E+ / Getty Images

Why Are Serotonin Levels Important?

Having adequate serotonin levels is important for your mental and physical health. Too little serotonin can increase your risk of depression and other mental health challenges like anxiety and obsessive-compulsive disorder (OCD).

Low levels of serotonin have also been associated with the development of certain diseases, including chronic fatigue syndrome (extreme, long-term fatigue), fibromyalgia (condition of widespread pain), Alzheimer’s, (progressive disease causing memory problems and mental confusion) and Parkinson’s (neurological disease affecting movement).

It’s also possible for serotonin levels to be too high. This can lead to serotonin syndrome, a rare condition that can cause symptoms ranging from mild (nervousness, nausea, diarrhea, tremors) to severe (sweating, fever, confusion).

There are several factors that can cause serotonin levels to fall too low. These include:

Tryptophan deficiency: The body can only make serotonin with tryptophan. The body can’t make this essential amino acid on its own, so it must be taken in through food. If you are not eating enough foods with tryptophan, then the body can’t make enough serotonin.
Other nutrient shortfalls: Research shows other nutrients, including vitamin D and probiotics, help to regulate the production, release, and function of serotonin.
Malfunction of serotonin receptors: In some cases, your body may make enough serotonin but is unable to use it efficiently. This is usually due to having too few serotonin receptors or having serotonin receptors that aren’t working properly.

Natural Ways to Boost Serotonin

Fill Up on These Feel-Good Foods

Serotonin is naturally produced by many plants. In fact, it’s currently found in about 42 plant species from 20 different families, most often in roots, leaves, stems, fruits, and seeds.

However, serotonin cannot cross the blood-brain barrier (a protective group of tightly packed cells that keep harmful substances from entering the brain), so eating foods with serotonin is not an effective way to raise serotonin levels.

Instead, it’s better to eat foods rich in the essential amino acid tryptophan, which can pass through the blood-brain barrier. Foods high in tryptophan include:

Animal protein, such as turkey, chicken, and fish
Eggs
Milk
Soy products like soybeans (edamame), tofu, seitan, soy milk
Nuts and seeds, including peanuts, sunflower seeds, pumpkin seeds, and sesame seeds

Studies suggest that increasing tryptophan intake can have a positive effect on mood and well-being, especially in individuals with tryptophan depletion.

It’s recommended that you consume tryptophan-rich foods with carbohydrates (such as bread, pasta, rice, or fruit). That’s because carbs trigger an insulin response that can help carry tryptophan over the blood-brain barrier.

Probiotics for Serotonin

An estimated 95{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} of the body’s serotonin is produced in the gut. Beneficial bacteria found in the gut (probiotics) secrete substances used in the creation of serotonin.

Research suggests that consuming foods rich in probiotics (including yogurt, kefir, kombucha, kimchi, and sauerkraut) helps build the population of good gut bacteria, which positively influences serotonin production. In several recent studies, probiotic consumption was associated with reduced depression and anxiety symptoms. More research is needed to confirm the results and most effective dosage.

Get 15 Minutes of Sunlight

Enjoying a few minutes outside on a sunny day works double-duty to boost serotonin levels: Bright light is known to promote serotonin output by stimulating the body’s circadian rhythm (its internal clock).

Plus, when the skin is exposed to sunlight, skin cells convert the sun’s ultraviolet B rays into vitamin D. Vitamin D plays an important role in the production and activation of serotonin, which can help with mood. One study found that increased sun exposure was associated with reduced depression symptoms in elderly women.

Experts say getting just 10–15 minutes of sun a day is enough to make adequate vitamin D in most people. If this is not possible, supplements are also available. The body can still produce vitamin D even when you’re wearing sunscreen, so be sure to use adequate protection, especially if you have pale or sensitive skin.

The Vitamin D and SAD Connection

Seasonal affective disorder, also known as SAD, is characterized by cyclical depressive symptoms occurring in the fall and winter months as the days get shorter and there is more darkness. This condition is thought to develop due to reduced levels of sun-derived vitamin D, which in turn leads to less serotonin production.

Treatment for seasonal affective disorder includes medication, therapies, and lifestyle changes.

Move Your Body

It’s commonly known that exercise is good for mental health. How does it help? In addition to endorphins (the hormones responsible for a “runner’s high”), research suggests that physical activity promotes the release of several mood-boosting chemicals, including dopamine and serotonin. This effect seems to reduce the risk of depression in those who regularly exercise.

Try some of these exercises to give yourself a serotonin boost:

Running/jogging
Swimming
Biking
Dancing
Jump rope
Yoga

If those activities are not suitable for you, you can also get benefits from low-impact activities such as taking a brisk walk, chair/water aerobics, and gardening activities, like weeding or raking.

Try Adaptogenic Herbs

Adaptogens are plant extracts that work to help keep the body in homeostasis, the balance of internal, chemical, and physical systems within the body. These herbs do this by improving the body’s ability to react and respond to stress and by helping to maintain hormonal balance.

Early research suggests that certain adaptogenic herbs may have antidepressant effects. More research is needed, yet there is some evidence that the following may have an antidepressant effect:

Rhodiola rosea (R. rosea)
Ginseng
Ashwagandha

Like with any complementary alternative medicine, it’s important to note that these herbs are not regulated by the Food and Drug Administration (FDA). It’s best to talk with your healthcare provider before trying any alternative treatment.

Stress Management

Chronic stress negatively impacts serotonin production and impairs the function of serotonin receptors. That means stress management can play an important role in maintaining optimal serotonin levels.

Here are some study-backed stress-relieving techniques to try:

While it’s not easy to eliminate stress from everyday life, simple stress management techniques can go a long way in helping you feel better.

Medications That Increase Serotonin Levels

Serotonin can be boosted synthetically, too. Antidepressants are a common line of treatment for depressive symptoms that may be due to low serotonin levels. There are several different kinds of antidepressants including:

Selective serotonin reuptake inhibitors (SSRIs): These meds work to keep serotonin circulating in the brain for long periods.
Serotonin-norepinephrine reuptake inhibitors (SNRIs): These work by keeping serotonin and norepinephrine circulating.
Tricyclic antidepressants: An older-generation class of drug that prevents the reabsorption of serotonin and norepinephrine.
Monoamine oxidase inhibitors (MOIs): This medication blocks the activity of an enzyme that breaks down serotonin, norepinephrine, and dopamine.

These antidepressants can be helpful for boosting serotonin levels, but they may also have side effects. However, these side effects can be mild and usually don’t last long. These may include:

Headache
Nausea
Insomnia or fatigue
Sexual issues

Sometimes people need to try a few different meds to find the antidepressant that works for them. Talk with your healthcare provider about any side effects you develop, and work with them to find the best fit.

Summary

Increasing serotonin levels can be done naturally. The best ways to do this are eating serotonin-boosting foods, getting out in the sun or supplementing with vitamin D, exercising, taking adaptogens, and managing stress.

Serotonin can also be increased synthetically, with antidepressants. While increasing serotonin is important for relieving depressive symptoms and improving mood, it’s not about getting as much serotonin as you can. Too much can also be harmful to your health. Finding the right balance is key.

A Word From Verywell

While you can’t really know how much serotonin you have in your body right now, you likely know when you don’t have as much as you need. When serotonin levels are low, you may feel blue or depressed.

Not having enough serotonin is nothing to be ashamed of. Many people struggle with low serotonin levels at times, especially during the dark winter months. Sometimes, having low levels is caused by something out of your control.

Though it can be hard to feel motivated to try new things to increase your serotonin levels when you’re feeling down, finding the right balance is possible.

Frequently Asked Questions

What happens when you don’t get enough serotonin?

Low levels of serotonin can lead to depressive symptoms. Not having enough serotonin is also associated with anxiety and sleep problems.

Are serotonin supplements safe?

Some are, but it’s important to use caution when trying them. Unlike antidepressants, which are prescribed to you by your healthcare provider and are regulated by the FDA, supplements do not require a prescription and are not regulated.

However, there is evidence to suggest that some supplements, like vitamin D, probiotics, and adaptogens, may be helpful in reducing depressive symptoms. Research is ongoing.

Do low levels of serotonin cause depression?

Not necessarily. While low levels of serotonin are often associated with depression, having low levels of serotonin does not automatically mean you will be depressed.

Can adaptogenic herbs boost serotonin?

Early research suggests that some adaptogenic herbs, including R. rosea, ginseng, and ashwagandha, may help boost serotonin and improve mood. These herbs and plant extracts are often used in Ayurveda (a form of alternative medicine that is the traditional medicine of India) and traditional Chinese medicine.

While adaptogens show promise for improving serotonin, it’s best to talk to your healthcare provider before trying them to make sure they are safe for you.

January 14, 2022

Pfizer Covid pills for Covid symptoms may be risky with other drugs.

As the omicron surge pummels a pandemic-weary nation, the initial antiviral capsules for Covid-19 assure desperately needed safety for people at risk of severe ailment. Having said that, several men and women prescribed Pfizer’s or Merck’s new medicines will call for watchful checking by doctors and pharmacists, and the antivirals may perhaps not be secure for all people, authorities warning.

Paxlovid, Pfizer’s Covid-19 tablet, is made in Ascoli, Italy.Pfizer through Reuters

The Foodstuff and Drug Administration approved Pfizer’s Paxlovid for gentle to average Covid in individuals as youthful as 12 who have underlying ailments that increase the hazard of hospitalization and dying from the coronavirus, these types of as heart sickness or diabetic issues. Nevertheless, just one of the two medications in the antiviral cocktail could induce intense or daily life-threatening interactions with commonly used medications, like statins, blood thinners and some antidepressants. And the Food and drug administration does not advise Paxlovid for folks with significant kidney or liver ailment.

Total protection of the Covid-19 pandemic

Simply because of experts’ considerations about the possible side consequences of Merck’s molnupiravir, the Fda has restricted its use to grownups and only in situations in which other licensed treatments, such as monoclonal antibodies, are inaccessible or are not “clinically ideal.”

The Paxlovid cocktail is made up of two tablets of the antiviral nirmatrelvir and just one tablet of ritonavir, a drug that has prolonged been employed as what is acknowledged as a boosting agent in HIV regimens. Ritonavir suppresses a crucial liver enzyme referred to as CYP3A, which metabolizes numerous drugs, which includes nirmatrelvir. In the situation of Paxlovid therapy, ritonavir slows the body’s breakdown of the active antiviral and allows it keep on being at a therapeutic level for more time.

The boosting impact was very likely to have been very important in driving Paxlovid’s large effectiveness in medical trials.

When Paxlovid is paired with other drugs that are also metabolized by the CYP3A enzyme, the chief fret is that the ritonavir part may possibly enhance the co-administered drugs to toxic degrees.

Complicating matters, the medication that pose interaction threats are commonly recommended to persons at the biggest hazard from Covid since of other health and fitness problems.

The prescription drugs include things like, but are not constrained to: blood thinners anti-seizure drugs medications for irregular coronary heart rhythms, high blood stress and substantial cholesterol antidepressants and anti-nervousness medicines immunosuppressants steroids (like inhalers) HIV remedies and erectile dysfunction remedies.

“Some of these prospective interactions are not trivial, and some pairings have to be averted entirely,” reported Peter Anderson, a professor of pharmaceutical sciences at the College of Colorado Anschutz Health care Campus. “Some are probably conveniently managed. But some we’re likely to have to be incredibly careful about.”

In its actuality sheet about Paxlovid, the Fda has released a in depth checklist of remedies that may possibly interact harmfully with ritonavir, including these that should not be paired with the Covid antivirals.

Even so, pharmacists stress that many of the drug interactions are workable and that they should really not preclude most people from using Paxlovid.

“Pharmacists are really experienced gurus in medication basic safety and checking and are an excellent resource of facts and information about interactions among medicines and also nutritional supplements and herbal goods,” mentioned Emily Zadvorny, a scientific pharmacist who is the government director of the Colorado Pharmacists Culture. “They will assist establish if a major interaction exists and devise solutions to mitigate the interaction if feasible.”

‘A breakthrough drug’

The superior news is that health and fitness treatment vendors have expertise navigating ritonavir’s use amid people with HIV — a team that generally usually takes remedies for other wellness situations, in addition to antiretroviral remedy.

Dr. William Werbel, an assistant professor of medication at Johns Hopkins University who specializes in transplant infectious diseases, suggested people at higher hazard of Covid-19 troubles to talk to their health treatment suppliers, as very well as a savvy pharmacist, about variations they could make to their drug regimens ought to they require Paxlovid — even prior to they come to be infected with the virus.

Anybody looking for Paxlovid, which must be approved in just 5 days of the initially indications, must be guaranteed to let their prescribers and pharmacists know the entire lists of other prescription drugs and over-the-counter supplements they are getting, Anderson said.

Some drugs, these types of as specific statins, are most possible harmless to halt taking throughout cure with the Covid products, Anderson said. For example, it may be improved to remain on certain blood thinners but to decrease the doses. Some coronary heart rhythm prescription drugs simply cannot be taken with Paxlovid.

Conversely, some anti-seizure medicines can increase liver enzymes’ metabolic action and thus lower the body’s Paxlovid ranges, as can the organic health supplement St. John’s Wort. The Fda warned that they really should not be combined with Paxlovid.

Because the Paxlovid cure is brief — 30 pills, taken as three drugs 2 times a working day for 5 times — industry experts are hopeful that the threat of adverse interactions with other medications is minimal.

“Five days of interactions is not a huge offer for the greater part of medication,” claimed Jason Gallagher, a scientific pharmacy specialist in infectious health conditions at Temple College Hospital in Philadelphia.

If a drug’s probable interaction with Paxlovid poses as well much of a possibility, Anderson reported, a safe and sound and productive alternative Covid-19 therapy would be GlaxoSmithKline’s sotrovimab — the sole licensed monoclonal antibody cure that exploration indicates reliably neutralizes the omicron variant of the virus. Otherwise, the antiviral molnupiravir is an option, albeit a single with a much reduced efficacy than either Paxlovid or sotrovimab.

Even with the problems about getting Paxlovid with other prescription remedies, specialists are psyched about the drug’s opportunity.

“Paxlovid is a breakthrough drug,” Anderson claimed. “This could make a serious difference in the pandemic by making an powerful Covid treatment method available to quite a few men and women.”

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December 27, 2021

Success of Covid Antiviral Pills Hinges on Access to Speedy and Accurate Tests

JoNel Aleccia, Kaiser Health News

Within a few weeks, perhaps before many Americans finish decorating for the holidays, the U.S. could have access to a new antiviral pill from Merck expected to alter the deadly trajectory of the covid-19 pandemic — with a second option from Pfizer to follow shortly after.

Now under federal review, both pills are being hailed by infectious-disease doctors not prone to superlatives.

“This is truly a game changer,” said Dr. Daniel Griffin, an expert on infectious diseases and immunology at Columbia University. “This is up there with vaccines. It’s not a substitute for vaccines; we still want to get people vaccinated. But, boy, this is just another great tool to have.”

The new regimens, which require 30 or 40 pills to be taken over five days, have been shown to dramatically reduce hospitalizations and prevent deaths in adults with mild to moderate covid who are at risk for severe disease because of age or underlying conditions. But experts say the success of the treatments would hinge on one uncertain factor: whether high-risk patients infected with covid will be able to get tested — and then treated — fast enough to make a difference.

“Early, accessible testing and access to the results in a time frame that allows us to make a decision is really going to be key to these medications,” said Dr. Erica Johnson, who chairs the Infectious Disease Board of the American Board of Internal Medicine. “It puts the onus on our public health strategy to make these available.”

In clinical trials, molnupiravir, the antiviral drug developed by Merck & Co. and Ridgeback Biotherapeutics, was given to non-hospitalized, unvaccinated, high-risk adult patients within five days of their first covid symptoms. Pfizer’s product, Paxlovid, was tested in similar patients as early as three days — just 72 hours — after symptoms emerged.

Results from the Merck trial, released last month, showed the drug reduced the risk of hospitalizations by about 50{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} and prevented deaths entirely. It will be considered by an advisory panel to the federal Food and Drug Administration on Nov. 30. Pfizer officials, who requested FDA emergency authorization for their drug on Nov. 16, said Paxlovid cut the risk of hospitalizations and deaths by 89{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}. Both drugs work by hampering the way the covid virus reproduces, though they do so at different points in the process.

But those promising results assume the drugs can be administered in the narrow window of time used in the trials, a proven challenge when getting antiviral treatments to actual patients. Similar drugs can prevent dire outcomes from influenza if given early, but research shows that only about 40{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} of high-risk patients during five recent flu seasons sought medical care within three days of falling ill.

“That’s just not human nature,” said Kelly Wroblewski, director of infectious disease programs for the Association of Public Health Laboratories. “If you have a sniffle, you wait to see if it gets worse.”

Even when patients do seek early care, access to covid testing has been wildly variable since the start of the pandemic. U.S. testing capacity continues to be plagued by a host of problems, including supply-chain bottlenecks, staffing shortages, intermittent spikes in demand and results that can take hours — or far longer.

PCR, or polymerase chain reaction tests, the gold standard to detect SARS-CoV-2, can require scheduled appointments at medical offices or urgent care centers, and patients often wait days to learn the results. Rapid antigen tests are faster but less accurate, and some medical providers are hesitant to rely on them. Over-the-counter tests that can be used at home provide results quickly but are hard to find in stores and remain expensive. And it’s not yet clear how those results would be confirmed and whether they would be accepted as a reason for treatment.

“Get ready,” Griffin said. “You don’t want to call someone four days later to say, ‘Ooh, you’re now outside the window,’ and the efficacy of this oral medication has been lost because of problems on our end with getting those results.”

The situation is expected to improve after a Biden administration push to invest $3 billion in rapid testing, including $650 million to ramp up manufacturing capacity for rapid tests. But it could be months before the change is apparent.

“Supplies will be getting better, but it’s going to be slow,” said Mara Aspinall, co-founder of Arizona State University’s biomedical diagnostics program, who writes a weekly newsletter monitoring national testing capacity.

If getting tests will be tough, acquiring doses of the antiviral drugs is expected to be tougher, at least at first. The federal government has agreed to purchase about 3.1 million courses of molnupiravir for $2.2 billion, which works out to about $700 per course of treatment. The Biden administration is planning to announce a deal to pay $5 billion for 10 million courses of the Pfizer drug, paying about $500 per treatment course, according to The Washington Post.

Doses of the drugs distributed by the federal government would go to states and patients at no cost. But only a fraction of the planned inventory will be available to start, said Dr. Lisa Piercey, Tennessee’s health commissioner, who has been part of a small group of state health officials working on the distribution plans.

Under one scenario, in which 100,000 courses of the Merck drug are available as early as Dec. 6, Piercey said Tennessee would receive just 2,000 patient courses even as the state is reporting more than 1,200 new cases a week on average. Deciding which sick patients receive those scarce supplies will be “an educated stab in the dark,” Piercey said.

U.S. Department of Health and Human Services officials have said the antiviral treatments will be distributed through the same state-based system adopted for monoclonal antibody treatments. The lab-made molecules, delivered via IV infusion or injection, mimic human antibodies that fight the covid virus and reduce the risk of severe disease and death. Federal officials took over distribution in September, after a covid surge in Southern states with low vaccination rates led to a run on national supplies. They’re now allotted to states based on the number of recent covid cases and hospitalizations and past use.

The antivirals will be cheaper than the monoclonal antibody treatments, which cost the government about $1,250 per dose and can carry infusion fees that leave patients with hundreds of dollars in copays. The pills are much easier to use, and pharmacies likely will be allowed to order and dispense them for home use.

Still, the antiviral pills won’t replace the antibody treatments, said Dr. Brandon Webb, an infectious-disease specialist at Intermountain Healthcare in Salt Lake City.

Questions remain about the long-term safety of the drugs in some populations. Merck’s molnupiravir works by causing mutations that prevent the virus from reproducing. The Pfizer treatment, which includes Paxlovid and a low dose of ritonavir, an HIV antiretroviral, may cause interactions with other drugs or even over-the-counter supplements, Webb said.

Consequently, the antivirals likely won’t be used in children, people with kidney or liver disease, or pregnant people. They’ll need to be administered to patients capable of taking multiple pills at once, a couple of times a day, and those patients should be monitored to make sure they complete the therapy.

“We’ll be on an interesting tightrope in which we’ll be trying to identify eligible patients early on to treat them with antivirals,” Webb said. “We’re just going to need to be nimble and ready to pivot.”

KHN (Kaiser Health News) is a national newsroom that produces in-depth journalism about health issues. Together with Policy Analysis and Polling, KHN is one of the three major operating programs at KFF (Kaiser Family Foundation). KFF is an endowed nonprofit organization providing information on health issues to the nation.

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November 23, 2021

Scam online pharmacies selling fake, dangerous pills find opportunity in the pandemic

The coronavirus pandemic has kick-started a host of on the internet and remote services, but not all of them are as valuable as expansions to telemedicine or having groceries requested on line and delivered to your doorstep: Pretend on line pharmacies have also proliferated all through COVID-19, putting their consumers at serious risk.

“Criminals will use any emergency or crisis to make revenue,” John Hertig, vice chair at Butler University’s University of Pharmacy and Well being Sciences and chairman of the Alliance for Risk-free On the net Pharmacies, explained to the Arizona Mirror.

Due to the pandemic, several men and women across the nation and in Arizona have been restricted in their actions, specially those with pre-existing wellbeing ailments that necessary unique medications. With that arrived a growth in faux on the web pharmacies taking gain of the condition, Hertig claimed.

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