Geneology International

Tag: safety

  • Bam Adebayo COVID-19 health and safety protocols update: How long is Heat star out in 2022 NBA playoffs?

    Bam Adebayo COVID-19 health and safety protocols update: How long is Heat star out in 2022 NBA playoffs?

    When the Warmth choose the courtroom to open the 2022 NBA Playoffs, there was a probability they would be without having just one of their best gamers.

    All-Star center Bam Adebayo entered COVID-19 wellbeing and protection protocols prior to Miami’s very last activity of the normal period towards the Magic.

    Adebayo, a two-time All-Defensive team choice, is the important to Erik Spoelstra’s defensive device, one particular that ranks fourth in the league in defensive score, according to NBA.com. He isn’t as well shabby on the other facet of the ball, either — he upped his scoring typical to a vocation-large 19.1 points for each sport on 55.7{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} shooting. All this for a participant who missed 26 online games immediately after struggling a torn UCL in his ideal thumb back in late November.

    Adebayo is 1 of the league’s brightest stars, capable of pouring buckets in on 1 end of the ground although locking down some of the league’s ideal threats in the paint. He proved as significantly in Miami’s run to the Finals back in 2020.

    Here is everything you want to know about Adebayo’s position heading into the series.

    When could Bam Adebayo return to the courtroom?

    Adebayo will be completely ready for Recreation 1.

    Adebayo entered health and fitness and security protocols last Sunday, according to Ira Winderman of the South Florida Sunlight-Sentinel.

    Miami hosts the Atlanta Hawks on Sunday, environment the stage for Adebayo to return in time for Match 1 of the series.

    IRVING: How 2022 NBA Playoffs can impact legacies of Chris Paul, James Harden and other stars

    Who will step up if Bam Adebayo is minimal?

    The Warmth have experienced to get used to getting without the need of Adebayo this season, and coming off of COVID-19 protocols, he could be restricted in Game 1.

    Veteran heart Dewayne Dedmon has started off 15 online games this time, and even though he doesn’t fairly possess Adebayo’s special mix of offensive talent and defensive solidity, he has carried out nicely in a platoon job. Dedmon has lengthy been one of the NBA’s best backup bigs, hardly ever obtaining shed in coverage when also serving as an productive deterrent to rim drives.

    On offense, meanwhile, Dedmon has demonstrated an effective article scorer and rim runner. The 9-yr vet has also additional a new wrinkle into his recreation this calendar year, flashing an enhanced 3-issue stroke. Dedmon is capturing 40 per cent from further than the arc, hitting 19 of his 47 tries in 67 online games this period.

    When he can not rather supply what Adebayo can, there are considerably worst possibilities than Dedmon. Miami won 10 of the 15 video games Dedmon started out this year. And in those game titles, Dedmon was quite effective, averaging 8.1 points and 8.1 assists in 23.1 minutes of game time.

    Dedmon may well not be able to recreate the gaudy numbers of Adebayo. But on a team brimming in talent — like Jimmy Butler, Kyle Lowry and Tyler Herro, as effectively as NBA Winner P.J. Tucker — he doesn’t need to.

  • Important update about Spring 2022 semester start and health and safety protocols | News

    Important update about Spring 2022 semester start and health and safety protocols | News

    Dear Vanderbilt local community,

    As we appear forward to the spring semester, we facial area yet one more problem from COVID-19 that will have to have our neighborhood to action up and perform with each other as A person Vanderbilt. The omicron variant is spreading rapidly throughout the nation and the planet. In light-weight of this, we should adapt to make certain that we can continue to pursue our educational and study mission as securely as attainable.

    To do that, we are taking these speedy steps:

    • The start off of the semester for undergraduates is delayed right up until Jan. 17, which is also Martin Luther King Jr. Working day. As in earlier decades, lessons will not be held that day to allow the neighborhood to participate in the virtual Commemorative Series events.
    • The dates for spring break (March 5–13) and Graduation (May perhaps 13) are unchanged. More element about the undergraduate academic calendar will be announced shortly.
    • Most graduate and expert applications will delay classes right until Jan. 17. Deans will communicate right with their learners, college and staff with faculty- and plan-precise data.
    • We are instituting enhanced security protocols for the total campus group, which includes a Commodores Care time period for pupils and the resumption of expected masking indoors.
    • In addition, we are tremendously expanding our testing software for the spring to help the wellness and security of our community. This will include essential screening for all returning learners right before they arrive on campus.

    Extra information and facts will be shared with you shortly, which include from academic deans, that will offer a lot more information.

    If you have not still attained your booster shot and are eligible, we strongly really encourage you to do so as shortly as doable and to register it on-line. Comprehensive vaccination in addition the booster is the most effective protection against COVID-19, and the documented facts considerably informs our designs. People who register their boosters will be exempt from quarantine in accordance with new CDC tips and subject matter to much less screening needs.

    Though there is continue to significantly to be learned about this variant and its impacts, we know that there will go on to be conditions in the Nashville community—and almost certainly a significant quantity of them—as we return to campus. Whilst it is possible that many members of our remarkably vaccinated campus local community who take a look at positive might continue to be asymptomatic or have only gentle indications, it is essential that we do all we can to protect the most vulnerable amongst us.

    In the deal with of this most recent obstacle, we are committed to continuing in-human being discovering. We are confident that if we do the job together to make overall health and basic safety a precedence, as we have effectively finished given that the commence of this pandemic, we can attain this intention. We will very carefully observe the data and will work carefully with our workforce of health and fitness professionals to information options for the spring semester and will share updates often.

    The pandemic has challenged us all, and we know the very first few months of the spring semester will be particularly tricky for some customers of our local community. We stimulate you to use campus means for mental health and fitness and properly-getting support and to assistance others when they are in have to have. We also encourage you to go to the upcoming virtual city halls for students and for college and workers.

    In the times ahead, locate time to relaxation and recharge as we head into 2022. We hope you are getting a fantastic break and would like you protected travels as you return to campus.

    Daniel Diermeier
    Chancellor

    Cybele Raver
    Provost and Vice Chancellor for Educational Affairs

    Eric Kopstain
    Vice Chancellor for Administration

    —

    Further facts for:

  • Health department provides tips on food safety for the holidays

    Health department provides tips on food safety for the holidays

    HARLINGEN, Texas (ValleyCentral) — As lots of put holiday getaway feasts out for pals and spouse and children to get pleasure from, health experts want to be positive you know leaving meals out for way too long can direct to illness.

    The town of Harlingen’s overall health department director, Josh Ramirez, stated hazardous organisms can be in meat and plant-primarily based foodstuff and individuals organisms can multiply.

    Ramirez described that it is important to cope with, get ready, and retail outlet food items properly to prevent any health and fitness problems.

    “E. coli which is the most common one that folks tend to overlook which is a thing that comes in the meat goods and it grows pretty fast underneath the right disorders,” he said.

    He reported cross-contamination and temperature can lead to the organisms these types of as E.coli to grow.

    “It is when it gets to be dangerously superior in numbers when it reaches the room temperature around 3 several hours, then it starts off growing and reproducing that the human body can’t manage and system that and which is when you come to be unwell,” stated Ramirez.

     He encouraged holding foods below 38 levels Fahrenheit or at 140 degrees Fahrenheit or greater to prevent organisms from developing and mentioned there is a good deal of misinformation out about storing warm foods in the fridge.

    “The difficulty is when you place a massive pot that is about seven to 8 inches deep with foods things in the refrigerator. You need to have to understand that in order for the cooling to access the middle it might take about 8 hrs if it’s scorching by now,” he stated,

    He explained employing shallow pans or trays to retail store very hot foods in the fridge will aid interesting the food stuff faster earning it safer to try to eat later.

    On the other hand, he reported there are also limits to how lengthy you can retail store leftovers ahead of they turn out to be unsafe.

    “Don’t let it go far more than 3 days to try to eat that contemporary item, they’re great up to seven days if the fridge is functioning accurately and you have the temperature set at the ideal degrees for that products,” he reported.

    Ramirez explained signs and symptoms such as tummy aches, diarrhea, vomiting, fever, and chills after consuming foodstuff you might imagine has long gone negative or remaining out for far too extended, should really be taken severely.

    “If you start off feeling indicators, seek the advice of your doctor correct absent, don’t enable it go much too prolonged, don’t say ‘well it will move,’ simply because you could danger functioning into a bigger issue, close up in a healthcare facility, or maybe die as well,” said Ramirez.

  • New COVID-19 safety guidance released after multi-county outbreak linked to high school wrestling tournaments > Washington State Department of Health” title=”New COVID-19 safety guidance released after multi-county outbreak linked to high school wrestling tournaments > Washington State Department of Health” src=”https://www.doh.wa.gov/portals/1/images/dohlogoblack-square.jpg” class=”attachment-post-thumbnail size-post-thumbnail wp-post-image” alt=”New COVID-19 safety guidance released after multi-county outbreak linked to high school wrestling tournaments > Washington State Department of Health” title=”New COVID-19 safety guidance released after multi-county outbreak linked to high school wrestling tournaments > Washington State Department of Health” style=”width:100%;height:100%;object-fit:cover;” decoding=”async” loading=”lazy” /></a></figure> <h2 class=New COVID-19 safety guidance released after multi-county outbreak linked to high school wrestling tournaments > Washington State Department of Health

    For rapid launch: December 17, 2021   (21-250)Spanish

    Get in touch with: DOH Communications

    General public inquiries: Condition COVID-19 Data Hotline, 1-800-525-0127

    New COVID-19 safety guidance unveiled immediately after multi-county outbreak joined to significant college wrestling tournaments

    OLYMPIA – The Washington State Division of Health and fitness (DOH), is updating the health and fitness and basic safety specifications for large speak to indoor sports activities in the wake of a multi-school, multi-county outbreak. The outbreaks are connected to a sequence of wrestling tournaments held in early December and are connected to an approximated 200 COVID-19 instances. Genomic sequencing lately confirmed at minimum a few circumstances are omicron.

    DOH normally takes these outbreaks quite critically and is altering the current steering by incorporating the subsequent wellness and basic safety measures for all indoor, superior-make contact with sports activities and things to do (basketball, wrestling, h2o polo, and aggressive cheer), powerful promptly:

      &#13

    • Expected tests of all athletes, coaches, trainers, and help staff, irrespective of vaccination position.

      • &#13

    • Elevated screening frequency to 3 situations per week. Amid people screening checks, at least one particular have to happen no faster than the working day prior to the competitors ideally, and anytime possible, the working day of the party.

      • &#13

    In addition, DOH desires to remind individuals of current prerequisites for all K-12 sporting events that assist preserve athletes, workers, and people safer when attending these gatherings:

      &#13

    • All indoor function spectators must wear masks and should really length from other people or homes to the diploma achievable.

      • &#13

    • Mask putting on is necessary among all athletes, coaches, trainers, and guidance personnel in indoor public areas apart from when actively competing.

      • &#13

    • Referees will have to put on masks apart from when actively officiated and working.

      • &#13

    DOH also acknowledges some of the influenced local health and fitness, education, or athletic leaders are choosing to postpone or terminate sporting occasions or pause sporting pursuits in buy to stop further more unfold of the condition. There may possibly be distinctions in how these activities are managed, so we would persuade people today to be affected person with any prospective process or scheduling alterations at the area level.

    “Omicron is a recreation-changer, but we know layered prevention actions gradual the spread of COVID-19 in sports, faculties, and communities.” mentioned Lacy Fehrenbach, Deputy Secretary for the COVID-19 response. “Please get vaccinated, boosted, use a very well-fitting mask, and manage your distance to aid our youngsters continue to be healthier, stay in the recreation, and continue to be in college.”

    “Vaccinations, in addition to tests and masking, will assistance preserve our athletes nutritious and enable all people to proceed to enjoy sporting situations when also limiting the distribute of disorder,” claimed Dr. Tao Sheng Kwan-Gett, Main Science Officer. “Getting a booster will make protection against the omicron variant even more robust. The booster vaccine is now readily available for every person 16 decades and more mature.”

    The DOH website is your resource for a nutritious dose of information and facts. Come across us on Fb and stick to us on Twitter. Indication up for the DOH site, General public Health Link. 

    ###

    Printable Variation (PDF)

  • Loudoun Co. health director offers COVID-19 holiday safety tips

    Loudoun Co. health director offers COVID-19 holiday safety tips

    With numerous men and women planning to rejoice Xmas with prolonged spouse and children for the very first time in two several years, Loudoun County wellness director Dr. David Goodfriend stated there are numerous things you should do to reduce COVID-19 from signing up for in.

    With several individuals planning to celebrate Xmas with extended household for the first time in two several years, Loudoun County wellbeing director Dr. David Goodfriend stated there are various items you ought to do to avert COVID-19 from becoming a member of the festivities.

    Irrespective of whether you system to get domestically or journey out of the place for a vacation, Goodfriend advisable a layered strategy together with vaccinations, screening, wearing masks and social distancing when indoors.

    “This is the best time to get your booster so that you will be thoroughly protected by Xmas,” Goodfriend claimed. “If you’ve not been vaccinated at all, you will not get total protection by getting vaccinated now, but it may possibly give you some.”

    So significantly, the omicron variant of COVID-19 has appeared moderate, but reportedly spreads additional quickly than delta, like to vaccinated persons. Goodfriend’s fears have been surrounded all those with delicate infections that could unfold to other, extra susceptible individuals.

    “Mild issues in youthful people may perhaps not be mild in our seniors,” Goodfriend explained. “What we’re acquiring is that notably with omicron … with no that booster shot, the efficiency of the vaccine does drop down substantially.”

    Goodfriend also explained testing will be significant to combatting the virus this getaway time.

    “If you feel you may have come in make contact with with COVID or have any signs and symptoms at all, get analyzed ahead of you go,” the doctor explained. “If you’re touring, you are likely to be in a close place with other folks, and even if they are vaccinated, that might be enough to make them ill.”

    They also pointed out that individuals can be stunned by their check effects.

    “Each week with our testing in the county, we uncover people who take a look at positive who did not feel they experienced any high hazard, did not have any symptoms, but just wished to get tested to be guaranteed,” Goodfriend said. “So there are easily a lot of individuals all over the region now who have no reason to consider that they would be contaminated. They’ve been thoroughly vaccinated, and they really don’t have any indicators but could be carrying the virus and passing it on to other folks.”

    Goodfriend stated it is continue to vital to don masks and retain a protected length from other people today you do not stay with when you are indoors, even if you are street-tripping and need to have to end for a fill-up at a fuel station.

    If you’re hosting a collecting and some company haven’t gotten vaccinated, you may perhaps think about inquiring attendees to get tested just before they come.

    “It truly is an individual case by circumstance problem of who’s staying invited, (and) what the threat variables are of individuals individuals currently being invited. If you’re inviting your 92-12 months-outdated grandparents, it’s extremely various than just acquiring 20-12 months-olds alongside one another,” Goodfriend said.

    Goodfriend warned that the coronavirus is spreading in the D.C. spot.

    “We’re seeing a very immediate increase in cases in Loudoun County and as a result of our area,” Goodfriend mentioned. So far, the county has not witnessed a substantial rise in hospitalizations or fatalities, but traditionally there is a lag time concerning a spike in cases and improves in folks heading to the clinic and even dying.

    He’s concerned about what the commence of the new yr will carry.

    “Every yr in our region, we come across that as folks come back again from Christmas holiday vacation, that is usually when the flu and other respiratory sicknesses pick up,” Goodfriend reported. “We do have prevalent influenza now in our region, which we did not have final year, and on top rated of that, we have higher transmission of COVID. So extremely likely, the selection of individuals who are sick, whether or not from flu, from COVID, or from other respiratory infections that are likely to be handed in the winter season, is likely to go up drastically in January.”

  • Efficacy and safety of medical cannabinoids in children: a systematic review and meta-analysis

    Efficacy and safety of medical cannabinoids in children: a systematic review and meta-analysis

  • 1.

    Park, J. Y. & Wu, L. T. Prevalence, reasons, perceived effects, and correlates of medical marijuana use: A review. Drug. Alcohol. Depend. 177, 1–13. https://doi.org/10.1016/j.drugalcdep.2017.03.009 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 2.

    Epidyolex|European Medicines Agency. https://www.ema.europa.eu/en/medicines/human/EPAR/epidyolex (2021).

  • 3.

    Anwar, A., Saleem, S., Patel, U. K., Arumaithurai, K. & Malik, P. Dravet syndrome: An overview. Cureus https://doi.org/10.7759/cureus.5006 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 4.

    Asadi-Pooya, A. A. Lennox-Gastaut syndrome: A comprehensive review. Neurol. Sci. 393(39), 403–414 (2017).


    Google Scholar     

  • 5.

    Swaminath, A. et al. The role of cannabis in the management of inflammatory bowel disease: a review of clinical, scientific, and regulatory informationcommissioned by the crohn’s and colitis foundation. Inflamm. Bowel Dis. 25, 427–435. https://doi.org/10.1093/ibd/izy319 (2019).

    Article 
    PubMed 

    Google Scholar     

  • 6.

    Aran, A., Cassuto, H., Lubotzky, A., Wattad, N. & Hazan, E. Brief report: Cannabidiol-rich cannabis in children with autism spectrum disorder and severe behavioral problems-a retrospective feasibility study. J. Autism Dev. Disord. 49, 1284–1288. https://doi.org/10.1007/s10803-018-3808-2 (2019).

    Article 
    PubMed 

    Google Scholar     

  • 7.

    Ben-Zeev, B. Medical cannabis for intractable epilepsy in childhood: A review. Rambam Maimonides Med. J. 11, e0004. https://doi.org/10.5041/RMMJ.10387 (2020).

    Article 
    PubMed Central 

    Google Scholar     

  • 8.

    Tramèr, M. R. et al. Cannabinoids for control of chemotherapy induced nausea and vomiting: Quantitative systematic review. Br. Med. J. 323, 16–21. https://doi.org/10.1136/bmj.323.7303.16 (2001).

    Article 

    Google Scholar     

  • 9.

    Pacher, P., Kogan, N. M. & Mechoulam, R. Beyond THC and endocannabinoids. Annu. Rev. Pharmacol. Toxicol. 60, 637–659. https://doi.org/10.1146/annurev-pharmtox-010818-021441 (2020).

    CAS 
    Article 
    PubMed 

    Google Scholar     

  • 10.

    Skrypek, M. M., Bostrom, B. C. & Bendel, A. E. Medical cannabis certification in a large pediatric oncology center. Children 6, 79. https://doi.org/10.3390/children6060079 (2019).

    Article 
    PubMed Central 

    Google Scholar     

  • 11.

    National Academies of Sciences, Engineering, and Medicine. The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. 58,91,97,245 (Washington, DC: The National Academies Press. 2017), DOI: https://doi.org/10.17226/24625.

  • 12.

    Bourgeois, F. T. et al. Pediatric versus adult drug trials for conditions with high pediatric disease burden. Pediatrics 130, 285–292. https://doi.org/10.1542/peds.2012-0139 (2012).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 13.

    Mueller, B. U. et al. Principles of pediatric patient safety: Reducing harm due to medical care. Pediatrics 143, 2. https://doi.org/10.1542/peds.2012-0139 (2019).

    Article 

    Google Scholar     

  • 14.

    Volkow, N. D., Baler, R. D., Compton, W. M. & Weiss, S. R. B. Adverse health effects of marijuana use. N. Engl. J. Med. 370, 2219–2227. https://doi.org/10.1056/NEJMra1402309 (2014).

    CAS 
    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 15.

    Kelly, B. F. & Nappe, T. M. Cannabinoid Toxicity. Treasure Island (FL): StatPearls (StatPearls Publishing, 2019). PMID: 29489164.

  • 16.

    Martín-Gómez, A., Palacios-Gómez, M. E. & García-Marcos, S. A. Severe intradialytic hypoglycemia associated with marijuana use. Nefrologia. 35, 328–329. https://doi.org/10.1016/j.nefroe.2015.02.001 (2015).

    Article 
    PubMed 

    Google Scholar     

  • 17.

    Naji, L. et al. The association between cannabis use and suicidal behavior in patients with psychiatric disorders: an analysis of sex differences. Biol. Sex Differ. 9, 22. https://doi.org/10.1186/s13293-018-0182-x (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 18.

    Ragazzi, T. C. C., Shuhama, R., Menezes, P. R. & Del-Ben, C. M. Cannabis use as a risk factor for psychotic-like experiences: A systematic review of non-clinical populations evaluated with the Community Assessment of Psychic Experiences. Early Interv. Psychiatry 12, 1013–1023. https://doi.org/10.1111/eip.12693 (2018).

    Article 
    PubMed 

    Google Scholar     

  • 19.

    Lev-Ran, S. et al. The association between cannabis use and depression: A systematic review and meta-analysis of longitudinal studies. Psychol. Med. 44, 797–810. https://doi.org/10.1017/S0033291713001438 (2014).

    CAS 
    Article 
    PubMed 

    Google Scholar     

  • 20.

    van Gastel, W. A. et al. Change in cannabis use in the general population: A longitudinal study on the impact on psychotic experiences. Schizophr. Res. 157, 266–270. https://doi.org/10.1016/J.SCHRES.2014.04.023 (2014).

    Article 
    PubMed 

    Google Scholar     

  • 21.

    Appelboam, A. & Oades, P. J. Coma due to cannabis toxicity in an infant. Eur. J. Emerg. Med. 13, 177–179. https://doi.org/10.1097/01.mej.0000194405.38206.f2 (2006).

    Article 
    PubMed 

    Google Scholar     

  • 22.

    Carstairs, S. D., Fujinaka, M. K., Keeney, G. E. & Ly, B. T. Prolonged coma in a child due to hashish ingestion with quantitation of THC metabolites in urine. J. Emerg. Med. 41, 3. https://doi.org/10.1016/j.jemermed.2010.05.032 (2011).

    Article 

    Google Scholar     

  • 23.

    Bonkowsky, J. L., Sarco, D. & Pomeroy, S. L. Ataxia and shaking in a 2-year-old girl: Acute marijuana intoxication presenting as seizure. Pediatr. Emerg. Care. 21, 527–528. https://doi.org/10.1097/01.pec.0000173349.38024.33 (2005).

    Article 
    PubMed 

    Google Scholar     

  • 24.

    Richards, J. R., Smith, N. E. & Moulin, A. K. Unintentional cannabis ingestion in children: A systematic review. J. Pediatr. 190, 142–152. https://doi.org/10.1016/j.jpeds.2017.07.005 (2017).

    Article 
    PubMed 

    Google Scholar     

  • 25.

    Corsi, D. J. et al. Maternal cannabis use in pregnancy and child neurodevelopmental outcomes. Nat. Med. 26, 1536–1540. https://doi.org/10.1038/s41591-020-1002-5 (2020).

    CAS 
    Article 
    PubMed 

    Google Scholar     

  • 26.

    Sadhana, D., Kathleen, M. & Jonathan, D. K. Marijuana and the pediatric population. Pediatrics https://doi.org/10.1542/peds.2019-2629 (2020).

    Article 

    Google Scholar     

  • 27.

    Wong, S. S. & Wilens, T. E. Medical cannabinoids in children and adolescents: A systematic review. Pediatrics 140, 5. https://doi.org/10.1542/peds.2017-1818 (2017).

    Article 

    Google Scholar     

  • 28.

    Devinsky, O. et al. Trial of cannabidiol for drug-resistant seizures in the dravet syndrome. N. Engl. J. Med. 376, 2011–2020. https://doi.org/10.1056/NEJMoa1611618 (2017).

    CAS 
    Article 
    PubMed 

    Google Scholar     

  • 29.

    Porcari, G. S., Fu, C., Doll, E. D., Carter, E. G. & Carson, R. P. Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center. Epilepsy Behav. 80, 240–246. https://doi.org/10.1016/j.yebeh.2018.01.026 (2018).

    Article 
    PubMed 

    Google Scholar     

  • 30.

    Devinsky, O. et al. Effect of cannabidiol on drop seizures in the lennox-gastaut syndrome. N. Engl. J. Med. 378, 1888–1897. https://doi.org/10.1056/NEJMoa1714631 (2018).

    CAS 
    Article 
    PubMed 

    Google Scholar     

  • 31.

    Lattanzi, S. et al. Efficacy and safety of cannabidiol in epilepsy: A systematic review and meta-analysis. Drugs 78, 1791–1804. https://doi.org/10.1007/s40265-018-0992-5 (2018).

    CAS 
    Article 
    PubMed 

    Google Scholar     

  • 32.

    de Carvalho, R. R., Almeida, K. J., da Silva, L. L., de Melo Mendes, C. M. & Bor-Seng-Shu, E. Efficacy and adverse event profile of cannabidiol and medicinal cannabis for treatment-resistant epilepsy: Systematic review and meta-analysis. Epilepsy Behav. 102, 106635. https://doi.org/10.1016/j.yebeh.2019.106635 (2020).

    Article 

    Google Scholar     

  • 33.

    Liberati, A. et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339, b2700. https://doi.org/10.1136/bmj.b2700 (2009).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 34.

    Ouzzani, M., Hammady, H., Fedorowicz, Z. & Elmagarmid, A. Rayyan-a web and mobile app for systematic reviews. Syst. Rev. 5(210), 1. https://doi.org/10.1186/s13643-016-0384-4 (2016).

    Article 

    Google Scholar     

  • 35.

    Sterne, J. A. et al. ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions. BMJ 355, i4919. https://doi.org/10.1136/bmj.i4919 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 36.

    Higgins, J. P. T. et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ 343, i7829. https://doi.org/10.1136/bmj.d5928 (2011).

    Article 

    Google Scholar     

  • 37.

    Busner, J. & Targum, S. D. The clinical global impressions scale: Applying a research tool in clinical practice. Psychiat. Edgmont 4(7), 28–37 (2007).


    Google Scholar     

  • 38.

    European Medicines Agency. Important medical event terms list (MedDRA version 23.0, updated). https://www.ema.europa.eu/en/documents/other/important-medical-event-terms-list-version-meddra-version-221_en.xls (2020).

  • 39.

    Viechtbauer, W. Conducting meta-analyses in R with the metafor. J. Stat. Softw. 36, 1–48. https://doi.org/10.18637/jss.v036.i03 (2010).

    Article 

    Google Scholar     

  • 40.

    Balduzzi, S., Rücker, G. & Schwarzer, G. How to perform a meta-analysis with R: A practical tutorial. Evid. Based. Ment. Health 22, 153–160. https://doi.org/10.1136/ebmental-2019-300117 (2019).

    Article 
    PubMed 

    Google Scholar     

  • 41.

    Rücker, G., Krahn, U., König, J., Efthimiou, O. & Schwarzer, G. Package ‘netmeta’ title network meta-analysis using frequentist methods. Epidemiol. Health https://doi.org/10.1007/978-3-319-21416 (2020).

    Article 

    Google Scholar     

  • 42.

    McGrath, S., Zhao, X., Steele, R. & Benedetti, A. Package ‘metamedian’ Title Meta-Analysis of Medians. (2020). https://doi.org/10.1002/sim.8013.

  • 43.

    Copenhagen Trial Unit. Trial Sequential Analysis Viewer. (2016).

  • 44.

    Wetterslev, J., Thorlund, K., Brok, J. & Gluud, C. Estimating required information size by quantifying diversity in random-effects model meta-analyses. BMC Med. Res. Methodol. 91(9), 1–12. https://doi.org/10.1186/1471-2288-9-86 (2009).

    CAS 
    Article 

    Google Scholar     

  • 45.

    Borenstein, M., Hedges, L., Higgins, J., Rothstein, H. & Biostat Englewood, N.J. Comprehensive Meta-Analysis 3. (2013).

  • 46.

    Dean, A.G., Sullivan, K.M., Soe, M.M. OpenEpi: Open source epidemiologic statistics for public health, Version. www.OpenEpi.com, updated 2013/04/06, accessed 2021/10/16.

  • 47.

    Page, M. J. et al. Epidemiology and reporting characteristics of systematic reviews of biomedical research: A cross-sectional study. PLOS Med. 13, e1002028. https://doi.org/10.1371/journal.pmed.1002028 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 48.

    Chan, S. G., Correia, A. J. & MecLeod, M. S. Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children: A double-blind, crossover trial. Pediatrics 79(6), 946–952 (1987).

    CAS 
    PubMed 

    Google Scholar     

  • 49.

    Dalzell, A. M., Bartlett, H. & Lilleyman, J. S. Nabilone: An alternative antiemetic for cancer chemotherapy. Arch. Dis. Child. 61, 502–505. https://doi.org/10.1136/adc.61.5.502 (1986).

    CAS 
    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 50.

    Miller, I. et al. Dose-ranging effect of adjunctive oral cannabidiol vs placebo on convulsive seizure frequency in dravet syndrome: A randomized clinical trial. JAMA Neurol. 77, 613–621. https://doi.org/10.1001/jamaneurol.2020.0073 (2020).

    Article 
    PubMed 

    Google Scholar     

  • 51.

    Fairhurst, C., Kumar, R., Checketts, D., Tayo, B. & Turner, S. Efficacy and safety of nabiximols cannabinoid medicine for paediatric spasticity in cerebral palsy or traumatic brain injury: a randomized controlled trial. Dev. Med. Child Neurol. 62, 1031–1039. https://doi.org/10.1111/dmcn.14548 (2020).

    Article 
    PubMed 

    Google Scholar     

  • 52.

    Efron, D. et al. A pilot randomised placebo-controlled trial of cannabidiol to reduce severe behavioural problems in children and adolescents with intellectual disability. Br. J. Clin. Pharmacol. 87, 436–446. https://doi.org/10.1111/bcp.14399 (2021).

    CAS 
    Article 
    PubMed 

    Google Scholar     

  • 53.

    Aran, A. et al. Cannabinoid treatment for autism: A proof-of-concept randomized trial. Mol. Autism 12, 1–11. https://doi.org/10.1186/S13229-021-00420-2 (2021).

    Article 

    Google Scholar     

  • 54.

    Devinsky, O. et al. Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome. Neurology 90, e1204–e1211. https://doi.org/10.1212/WNL.0000000000005254 (2018).

    CAS 
    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 55.

    Chesney, E. et al. Adverse effects of cannabidiol: A systematic review and meta-analysis of randomized clinical trials. Neuropsychopharmacology 45, 1799–1806. https://doi.org/10.1038/s41386-020-0667-2 (2020).

    CAS 
    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 56.

    Malyshevskaya, O. et al. Natural (∆ 9 -THC) and synthetic (JWH-018) cannabinoids induce seizures by acting through the cannabinoid CB 1 receptor. Sci. Rep. 2017(7), 1–8. https://doi.org/10.1038/s41598-017-10447-2 (2017).

    CAS 
    Article 

    Google Scholar     

  • 57.

    FDA Approves First Drug Comprised of an Active Ingredient Derived from Marijuana to Treat Rare, Severe Forms of Epilepsy. FDA https://www.fda.gov/news-events/press-announcements/fda-approves-first-drug-comprised-active-ingredient-derived-marijuana-treat-rare-severe-forms (2018).

  • 58.

    Ruggiero, A. et al. Acute chemotherapy-induced nausea and vomiting in children with cancer: Still waiting for a common consensus on treatment. J. Int. Med. Res. 46, 2149–2156. https://doi.org/10.1177/0300060518765324 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 59.

    NICE. Cannabis-based medicinal products: [A] Evidence review for intractable nausea and vomiting NICE guideline NG144 Evidence review underpinning recommendations 1.1.1 and 1.1.2 in the NICE guideline. (2019).

  • 60.

    Huestis, M. A. et al. Cannabidiol adverse effects and toxicity. Curr. Neuropharmacol. 17, 974–989. https://doi.org/10.2174/1570159×17666190603171901 (2019).

    CAS 
    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 61.

    Stockings, E. et al. Evidence for cannabis and cannabinoids for epilepsy: a systematic review of controlled and observational evidence. J. Neurol. Neurosurg. Psychiat. 89, 741–753. https://doi.org/10.1136/JNNP-2017-317168 (2018).

    Article 
    PubMed 

    Google Scholar     

  • 62.

    Wiley, J. L. et al. CB1 cannabinoid receptor-mediated modulation of food intake in mice. Br. J. Pharmacol. 145, 293. https://doi.org/10.1038/SJ.BJP.0706157 (2005).

    CAS 
    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 63.

    Jankowska, B. I., Jankowski, M. M. & Swiergiel, A. H. Cannabidiol decreases body weight gain in rats: involvement of CB2 receptors. Neurosci. Lett. 490, 82–84. https://doi.org/10.1016/J.NEULET.2010.12.031 (2011).

    Article 

    Google Scholar     

  • 64.

    Skluzacek, J. V., Watts, K. P., Parsy, O., Wical, B. & Camfield, P. Dravet syndrome and parent associations: The IDEA League experience with comorbid conditions, mortality, management, adaptation, and grief. Epilepsia 52, 95–101. https://doi.org/10.1111/j.1528-1167.2011.03012.x (2011).

    Article 
    PubMed 

    Google Scholar     

  • 65.

    Bandini, L. G. et al. Changes in food selectivity in children with autism spectrum disorder. J. Autism Dev. Disord. 47, 439–446. https://doi.org/10.1007/s10803-016-2963-6 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 66.

    Di Marzo, V. & Piscitelli, F. The endocannabinoid system and its modulation by phytocannabinoids. Neurotherapeutics 12, 692. https://doi.org/10.1007/s13311-015-0374-6 (2015).

    CAS 
    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 67.

    Zou, S. & Kumar, U. Cannabinoid receptors and the endocannabinoid system: Signaling and function in the central nervous system. Int. J. Mol. Sci. 1, 9. https://doi.org/10.3390/ijms19030833 (2018).

    CAS 
    Article 

    Google Scholar     

  • 68.

    Netzahualcoyotzi, C., Rodríguez-Serrano, L. M., Chávez-Hernández, M. E. & Buenrostro-Jáuregui, M. H. Early consumption of cannabinoids: From adult neurogenesis to behavior. Int. J. Mol. Sci. 22, 7450. https://doi.org/10.3390/ijms22147450 (2021).

    CAS 
    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 69.

    Solowij, N. et al. Therapeutic effects of prolonged cannabidiol treatment on psychological symptoms and cognitive function in regular cannabis users: A pragmatic open-label clinical trial. Cannabis Cannabinoid. Res. 3, 21–34. https://doi.org/10.1089/can.2017.004 (2018).

    CAS 
    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • 70.

    Osborne, A. L., Solowij, N. & Weston-Green, K. A systematic review of the effect of cannabidiol on cognitive function: Relevance to schizophrenia. Neurosci. Biobehav. Rev. 72, 310–324. https://doi.org/10.1016/j.neubiorev.2016.11.012 (2017).

    CAS 
    Article 
    PubMed 

    Google Scholar     

  • 71.

    Sidik, K. & Jonkman, J. N. A comparison of heterogeneity variance estimators in combining results of studies. Stat. Med. 26, 1964–1981 (2007).

    MathSciNet 
    Article 

    Google Scholar