Geneology International

Category: Alternative Medicine

  • LGBTQ+ Patients Have Higher Risk of Breast Cancer Recurrence

    LGBTQ+ Patients Have Higher Risk of Breast Cancer Recurrence

    LGBTQ+ clients with breast cancer encounter delays in analysis and have worse results than cisgender heterosexual individuals, according to investigate released in JAMA Oncology.

    Scientists located that LGBTQ+ sufferers have a better threat of cancer recurrence, and they are additional very likely to decrease their oncologist’s advisable study course of remedy.

    This retrospective, situation-regulate study provided 92 LGBTQ+ clients and 92 matched cisgender heterosexual clients. All individuals were being identified with breast cancer in a single health and fitness care technique involving January 2008 and January 2022.

    Go on Examining

    The demographic traits of the cohorts had been equivalent, besides for race and ethnicity. The LGBTQ+ team had extra non-Hispanic White clients (78.3{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} vs 63.{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}) and Hispanic sufferers (14.1{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} vs 7.6{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}) but much less Asian or Pacific Islander sufferers (3.3{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} vs 25.{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}) than the cisgender heterosexual group.

    In equally teams, the median age at analysis was 49 many years, and most sufferers experienced personal coverage. Baseline illness qualities have been very similar amongst the groups.

    Between the LGBTQ+ clients, 74 (80.4{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}) ended up cisgender lesbians, 12 (13{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}) had been cisgender bisexuals, 4 (4.3{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}) were heterosexual transgender males, 1 (1.1{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}) was a gay transgender guy, and 1 (1.1{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}) was an asexual transgender person. 

    The median time from symptom onset to diagnosis was lengthier for LGBTQ+ patients than for cisgender heterosexual individuals — 64 days and 34 times, respectively (modified hazard ratio [aHR], .65 95{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} CI, .42-.99 P =.04). 

    Nevertheless, the time from analysis to procedure was identical involving the groups. In addition, there had been no differences in prices of mastectomy, chest reconstruction, adjuvant radiation, neoadjuvant chemotherapy, antiestrogen treatment, or HER2-qualified remedy amongst the groups. 

    LGBTQ+ people ended up far more probable than cisgender heterosexual individuals to decline oncologist-suggested therapy — 38{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} and 20{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, respectively (altered odds ratio, 2.27 95{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} CI, 1.09-4.74 P =.03). The use of alternate medicine was bigger in LGBTQ+ sufferers than in cisgender heterosexual sufferers as perfectly — 46{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} and 30{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, respectively.

    The charge of recurrence was greater in LGBTQ+ individuals than in cisgender heterosexual individuals — 32.2{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} and 13.3{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, respectively. Area recurrence costs ended up 17.3{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} and 2.5{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, respectively. Fees of metastatic recurrence were being 24.7{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} and 13.6{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}, respectively.

    In a multivariable analysis, the chance of recurrence was 3-fold larger for LGBTQ+ clients (aHR, 3.07 95{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} CI, 1.56-6.03 P =.001).

    The scientists suggested that these disparities be further more investigated in potential, populace-dependent scientific studies, with the intention of informing wellness treatment interventions and bettering quality of treatment for LGBTQ+ people with breast cancer.

    Reference

    Eckhert E, Lansinger O, Ritter V, et al. Breast cancer diagnosis, therapy, and results of individuals from sexual intercourse and gender minority teams. JAMA Oncol. Published on-line February 2, 2023. doi:10.1001/jamaoncol.2022.7146

  • Kimberly Bailey Had Investigator Rick Post Tortured, Killed

    Kimberly Bailey Had Investigator Rick Post Tortured, Killed

    When millionaire Kimberly Bailey found out her sometime-boyfriend, Rick Post, was sleeping around and stealing from her, she had him kidnapped, tortured, and murdered. But it turned out Rick’s business associate was the one telling Bailey lies to get him out of the way.

    Richard “Rick” Post was born in 1945 and grew up in San Diego, California. He joined the U.S. Army at the age of 18 and served in the Vietnam War. 

    “He scored the highest IQ test in the whole western seaboard of the Army so they immediately put him into Army Intelligence,” Rick’s son Ian Post told “Snapped,” airing Sundays at 6/5c on Oxygen.

    Rick was married twice and had four kids. To support his family, he put his military training to use, opening Intellisource Security And Investigative Services, Inc. in San Diego.

    “The type of work ranged anywhere from, we’ll call it investigation to cheating investigation of a spouse or husband and anything in between,” said Ian.

    Rick wasn’t afraid of dangerous assignments and also worked murder cases that brought him face to face with killers.

    In the late 1990s, he hired aspiring young private investigator John Krueger to help with his caseload. 

    Then, in 1997, Intellisource was hired by a woman named Kimberly Bailey. Bailey owned a 33-acre farm north of San Diego where she grew holistic medicines and avocados and also sold alternative medical devices. 

    “She had a business known as AstroPulse and the idea was that by using electrical currents you could cure pretty much anything,” former FBI Special Agent Jeffrey Thurman told “Snapped.”

    By her early 40s, Bailey was a multi-millionaire. With success though, came suspicions. 

    “Kim was rather paranoid. She always believed that someone was watching her or after her,” former business associate Kenneth Altpeter told “Snapped.”

    Fearful people were stealing from her, Bailey hired Intellisource. The relationship between her and Rick eventually went from professional to romantic, but Rick later broke it off with Bailey.

    “I do remember my father telling me at our home he wanted to keep this relationship professional, that he did not want to have a romantic relationship with her,” said Ian Post.

    But then, on August 21, 1998, a secretary at Intellisource called 16-year-old Ian Post and asked if he knew where his father was. Ian hadn’t seen him in 24 hours and calls to his phone went unanswered. Rick’s car was parked in front of his house with the keys in the mailbox.

    Though Ian was used to his father leaving town abruptly for work, Rick always told him when he would be back and would make arrangements for someone to look after the teenager. 

    “Rick didn’t tell his 16-year-old boy that he was going any place. Took no clothes. Took no medications with him. That’s not a normal business trip. That’s suspicious,” former FBI Special Agent Nick McKean told “Snapped.”

    RELATED: ‘Show Me What Kind Of Man You Are,’ Woman Texts Boyfriend While Plotting Ex’s Murder

    John Krueger contacted Ian a week later to say Rick had left a voicemail message at the office. 

    “The voicemail was Rick’s voice and was directed to his office staff saying that he was going to be in Mexico for a few days and he was fine, not to worry about him,” FBI Special Agent Brett Fenoglio told “Snapped.”

    Though Krueger insisted the message was left the day before he disappeared, Ian thought it sounded like his father was being coerced.

    “It really wasn’t what my father was saying, it was his candor, the way he spoke,” said Ian.

    The Post family filed a missing persons report in August 1998. 

    Krueger told investigators he had last seen Rick on August 20, in the company of Kimberly Bailey. They then interviewed Bailey, who said she and Rick had traveled to Mexico for business on August 20. She claimed they went out for a meal while in Tijuana, during which Rick was approached by two men. 

    “At the conclusion of the conversation, Rick told Kimberly that he needed to make a business trip to Mexico City,” said Thurman.

    Bailey claimed she took Post to the airport where he boarded a plane. She then drove his car back to his home in San Diego, leaving the keys in his mailbox.  

    But four months later, the U.S. Attorney’s Office was contacted by lawyer Coleen Cusack. She was seeking blanket immunity for a client in exchange for information about the kidnapping and murder of a San Diego resident. The U.S. The Attorney’s Office refused the deal but passed the information to the FBI. With the few details they had, investigators believed the victim was Rick Post.  

    In May 1999, the FBI attempted to re-interview John Krueger. He said he would first have to speak with his lawyer, Coleen Cusack. He subsequently ended the interview. 

    “At that point we quickly made the connection that Rick Post was not just a missing person. Rick was murdered and John Krueger has information directly related to the kidnap of Rick Post,” said Fenoglio. 

    The FBI also learned Kimberly Bailey was under investigation for fraud related to the medical devices she sold and put her under surveillance. In November 1999, the FBI went to Bailey’s farm. There, they spoke with farmhand Bruce Perlowin and his wife, Svetlana Ogorodnikova. 

    “This moment was a jaw dropper for the agents. Svetlana was someone that was known to virtually every FBI agent who joined the agency during the 1980s and 1990s,” said Thurman. 

    During the 1980s, Ogorodnikova was convicted of espionage after seducing a Los Angeles FBI agent and passing confidential documents to the Soviet Union. She served nine years in prison before being deported and moving to Tijuana with her husband, according to the Berkeley Daily Planet newspaper. Ogorodnikova and Perlowin later entered the United States illegally and worked for Bailey at her farm. 

    Ogorodnikova said Bailey was upset Post broke off their romance and suspected him of stealing from her.  

    “Kimberley Bailey had actually confided in Svetlana that she had orchestrated the kidnap and murder of Rick Post,” said Fenoglio.

    Ogorodnikova agreed to record Bailey talking about the murder. The perfect opportunity arrived when Bailey asked Ogorodnikova to pick her up in Arizona and drive her back to California. Hidden recording devices in the car caught Bailey sharing details of Rick Post’s grim end.

    Kayla Nelson Kimberly Baldwin

    Bailey said Krueger had contacted her in August 1999 and told her Rick was stealing her money and sleeping around behind her back. Enraged, Bailey paid $40,000 to have an associate of Krueger’s named Humberto Iribe kidnap and torture Rick, according the Los Angeles Times.

    Bailey lured Rick to Tijuana where he was abducted by Iribe and tortured for five days, enduring beatings and having his fingers crushed with pliers. Bailey said she would travel down to where he was kept in Mexico to watch the torture.

    “Rick said, ‘I admit that I slept with other women.’ He’s always denied stealing anything,” Bailey told Ogorodnikova on the recordings, which were obtained by “Snapped.”  

    Bailey claimed she wanted to keep Rick alive and imprison him in a private dungeon but that Iribe said it was too dangerous. 

    “That’s when I said, ‘Do what you have to do,’” Bailey told Ogorodnikova.

    Bailey would later pay Iribe an additional $10,000 to have Rick executed, according to the Los Angeles Times. 

    Bailey subsequently asked Ogorodnikova to help her find someone to kill Krueger and Iribe. A meeting was set up between Bailey and former FBI Special Agent Nick McKean posing as a hitman.

    “She wanted three people killed. She wanted John Kreuger. She wanted her attorney and then she wanted her gardener,” said McKean. “I couldn’t get her to tell me why she wanted her gardener killed. Still don’t know.” 

    She then gave him $10,000 as a down payment.

    John Krueger was arrested in April 2000 in San Diego. Later that month, Kimberly Bailey was arrested at a Mexico City airport, where she was traveling with a Canadian passport. Humberto Iribe would avoid arrest until 2003, when he was extradited to the United States.          

    Krueger pleaded guilty to conspiring to kidnap Rick Post and agreed to testify against Bailey at her trial. He was sentenced to 12 years in prison and five years of supervised release, according to the Los Angeles Times, and released from prison in 2010. 

    He told authorities he was angry at Rick for not paying him enough. He admitted to fabricating the stories about Rick stealing from Bailey in order to rile her up.  

    “It was actually John Krueger who dripped the first poison in Kimberley Bailey’s ear, knowing how paranoid Kimberly Bailey was. John Krueger orchestrated this plot to get rid of Rick Post so that John could take over the business,” said Fenoglio.   

    Kimberley Bailey was convicted of kidnapping, conspiracy to kidnap, and using interstate commerce in a murder-for-hire scheme in connection with the disappearance of Richard Post. In 2003, she was sentenced to life in prison, according to The San Diego Union-Tribune newspaper.

    She died while incarcerated in 2008 after being diagnosed with cancer. 

    Humberto Iribe was found guilty of conspiracy and attempted kidnapping and sentenced to 25 years in prison. He was scheduled for release in December 2022, according to court documents.    

    For more on this case and others like it, watch “Snapped,” airing Sundays at 6/5c on Oxygen, or stream episodes here.

  • Here’s Why Big Pharma Spends More On Ads Pushing Lower Benefit Drugs, Study Suggests

    Here’s Why Big Pharma Spends More On Ads Pushing Lower Benefit Drugs, Study Suggests

    Topline

    Major pharma spends much more revenue on promotion for medicine that have lessen health and fitness gains for people, according to a analyze published in JAMA on Tuesday, shedding new light on the pretty much uniquely American observe amid fierce discussion in excess of irrespective of whether direct-to-customer prescription drug ads need to be banned.

    Crucial Info

    The proportion of marketing expending allocated to direct-to-consumer advertisements was an ordinary of 14.3 percentage details increased for medicine with a very low added benefit compared to all those with a substantial included advantage, according to the peer-reviewed evaluation of the 150 very best-selling branded prescription medication in 2020.

    Nearly two-thirds of the country’s best-selling prescription drugs—92 of the 135 medicines details was out there for—were rated as presenting individuals lower extra reward by health companies in France and Canada, the scientists identified, relying on the foreign companies as no U.S. company compares prescription prescription drugs for success.

    Promotional spending for prescription medicine different wildly, the scientists claimed, with a median shell out of $20.9 million for each drug and a median of 13.5{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c} of the advertising budget allocated to direct-to-customer ads.

    Manufacturers of the best six very best-advertising medicine invested the bulk of their advertising budgets—more than 90{fe463f59fb70c5c01486843be1d66c13e664ed3ae921464fa884afebcc0ffe6c}—targeting people right relatively than clinicians for a variety of treatment method selections for situations which include HIV, various sclerosis and many cancers.

    Meanwhile medicines that take care of metabolic troubles and digestive tract challenges been given a substantially decrease share of immediate-to-client promotion in comparison to all round advertising budgets, the scientists mentioned.

    The findings could propose pharma corporations are aiming marketing pounds immediately in direction of buyers, relatively than clinicians, as element of a “strategy to generate patient demand from customers for medications that clinicians would be significantly less most likely to prescribe,” claimed the study’s guide author Michael DiStefano, a researcher at Johns Hopkins.

    Surprising Actuality

    Just two nations in the globe permit drug makers to industry prescription medications immediately to buyers: the U.S. and New Zealand. Most countries ban the observe.

    Key History

    Most nations around the world prohibit right advertising and marketing prescription remedies to the community, a little something the WHO states influences both of those men and women and, indirectly, the health care pros treating them, creating it “harder to make choices on evidence dependent medicine.” The American Medical Affiliation opposes the apply and, alongside other health and fitness organizations, is pushing to outlaw it in the U.S. Pharmaceutical companies assert individuals gain from the commercials and that they have a ideal to know what selections are offered to them. Critics argue the ability to sideline professionals and marketplace to the community directly incentivizes organizations to exaggerate the advantage of their medications with out detailing attainable facet outcomes, a condition regulators hoped to cure by requiring adverts to dedicate time to hazards, primary to the well-recognized, speedy fire laundry record of aspect outcomes.

    Major Selection

    $6 billion. That’s how considerably researchers estimate pharma used on direct to client adverts in 2016. The determine grew noticeably from 1996, when purchaser ad budgets totaled $1.3 billion.

    Essential Quote

    “Another thought is the U.S. doesn’t at the moment level prescription medicines,” explained research writer Gerard Anderson, a professor of well being coverage at Johns Hopkins. “Imagine if the drug advertisements you noticed on Television have been needed to convey to you how well the drug executed in opposition to alternate drugs for the similar ailment. That may possibly improve how fascinated you would be in the drug.”

    Further more Reading through

    How lax social media policies assist fuel a prescription drug increase (Protocol)

  • Columbia Care Celebrates Launch of Adult Use Cannabis Sales in Missouri | News

    Columbia Care Celebrates Launch of Adult Use Cannabis Sales in Missouri | News

    NEW YORK–(Enterprise WIRE)–Feb 6, 2023–

    Columbia Care Inc. (NEO: CCHW) (CSE: CCHW) (OTCQX: CCHWF) (FSE: 3LP) (“Columbia Care” or the “Company”), just one of the premier and most experienced cultivators, manufacturers and stores of hashish goods in the U.S., introduced it commenced adult-use profits on February 4 at its Cannabist i dispensary, situated in Hermann, Missouri. The dispensary has been serving the clinical affected person group considering the fact that 2021.

    “We are thrilled to see the swift action taken by the Department of Health and Senior Companies to bring leisure hashish to Missourians so before long after the ballot measure passed in November. It has been a privilege to run in these types of a promptly escalating marketplace and serve our patients in the neighborhood Hermann group. We search ahead to welcoming new buyers as a result of our doorways in the coming weeks and introducing them to our Cannabist experience,” reported Jesse Channon, Main Expansion Officer, Columbia Treatment.

    Cannabist Hermann presents a extensive selection of solutions as well as manufacturers, which include Columbia Care’s Amber, Classix, Hedy and Seed & Pressure. In addition to its dispensary in Hermann, the Firm also operates a producing facility in nearby Columbia, Missouri, which produces vapes, edibles and pre-rolls.

    For much more data, pay a visit to https://gocannabist.com/hermann.

    i Cannabist Hermann is managed by Columbia Treatment, LLC on behalf of Columbia Care MO, LLC by way of a managed providers arrangement.

    About Columbia Care

    Columbia Care is 1 of the premier and most seasoned cultivators, makers and vendors of hashish goods and connected providers, with licenses in 18 U.S. jurisdictions. Columbia Care operates 128 services which includes 95 dispensaries and 33 cultivation and producing facilities, together with people beneath enhancement. Columbia Care is one particular of the initial multi-state vendors of health-related cannabis in the U.S. and now delivers industry-foremost goods and expert services to equally the medical and grownup-use markets. In 2021, the firm introduced Cannabist, its new retail brand, creating a national dispensary network that leverages proprietary know-how platforms. The business features goods spanning flower, edibles, oils and tablets, and manufactures popular models including Seed & Strain, Triple Seven, Hedy, gLeaf, Classix, Push, and Amber. For more information on Columbia Treatment, you should visit www.columbia.care.

    Caution About Ahead-Hunting Statements

    This push launch has certain statements that constitute “forward-looking information” or “forward-on the lookout statements” within the indicating of relevant securities laws and reflect the Company’s present-day expectations concerning future activities. Ahead-searching statements or information and facts contained in this release include, but are not restricted to, statements or info with regard to the Company’s ability to execute on retail, wholesale, manufacturer and product or service initiatives. These ahead-wanting statements or details, which even though considered sensible by the Firm, could verify to be incorrect and are matter to recognised and unknown hazards and uncertainties that may well result in actual outcomes, performance or achievements of the Firm to be materially various from those people expressed or implied by any ahead-wanting information. These risks, uncertainties and other factors include things like, amid other folks, favorable running and financial disorders acquiring and retaining all expected licenses and permits favorable manufacturing amounts and sustainable expenses from the Company’s functions and the amount of demand for hashish products and solutions, such as the Company’s items bought by third functions. In addition, securityholders ought to assessment the danger factors mentioned underneath “Risk Factors” in Columbia Care’s Kind 10 dated May perhaps 9, 2022, filed with the applicable securities regulatory authorities and described from time to time in documents submitted by the Firm with Canadian and U.S. securities regulatory authorities.

    Check out supply model on businesswire.com:https://www.businesswire.com/news/home/20230206005260/en/

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    Marketplace Search phrase: Alternate Medication Cannabis Health and fitness Buyer Women of all ages All-natural Sources Gentlemen

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  • From Clinical Trials to Real-World Practice, Experts Examine the Best Options for TNBC

    From Clinical Trials to Real-World Practice, Experts Examine the Best Options for TNBC

    CancerNetwork® recently hosted a first-of-its-kind Tweet Chat with co-hosts Hope S. Rugo, MD, and Paolo Tarantino, MD. Together, they reviewed a patient case of a 52-year-old woman who had been diagnosed with stage IIA triple-negative breast cancer (TNBC) and went into detail regarding treatment options for the metastatic population.

    Rugo, a professor of medicine, and director of Breast Oncology and Clinical Trials Education at the University of California San Francisco Helen Diller Comprehensive Cancer Center; and Tarantino, a Clinical Research Fellow at Dana-Farber Cancer Institute, also examined the use of neoadjuvant therapeutics for early disease and potential adjuvant therapy-sparing regimens.

    During the live Tweet Chat, both experts detailed the impact of antibody-drug conjugates (ADCs) on survival outcomes and the best approach for treating patients following disease recurrence after first-line therapy.

    In the first part of the patient case of a 52-year-old woman with stage IIA TNBC, Rugo mentioned the need for neoadjuvant chemotherapy, “We recommend [neoadjuvant chemotherapy] in this case, following the KN522 regimen. The [addition] of [pembrolizumab increases] pCR and EFS. @SABCS22 Gupta showed better outcomes adding platinum to T/[adjuvant chemotherapy].”

    Tarantino responded with results from the phase 3 KEYNOTE-522 trial (NCT03036488) wherein patients with TNBC received pembrolizumab (Keytruda) plus chemotherapy vs placebo as a neoadjuvant treatment and pembrolizumab vs placebo as adjuvant treatment.1

    Rugo questioned if there is a need to wait a year after starting pembrolizumab for a partial complete response (pCR) to be observed and, if not, whether capecitabine/pembrolizumab is a good alternative treatment option.

    Additionally, she introduced several studies assessing sacituzumab govitecan-nxki (Trodelvy) in patients with TNBC, “OptimICE pCR is an ALLIANCE trial that will randomize [patients] to [pembrolizumab] or not in those with pCR. OptimICE RD and the [phase 3] SASCIA trial [NCT04595565] are evaluating the addition of sacituzumab govitecan in patients with residual disease.”

    In response, Tarantino discussed data from phase 2 GeparNuevo trial (NCT02685059) which added a PD-L1 antibody to taxane chemotherapy.2 In this trial, patients had a high invasive disease-free survival. While OptimICE-pCR is still enrolling patients, he hopes that the results will show the ability to spare adjuvant immunotherapy.

    Next steps of treatment was also a topic of conversation, as the patient experienced recurrence after adjuvant capecitabine and radiation.

    Tarantino responded that chemotherapy and taxane rechallenge is the current standard of care for recurrent TNBC, “[Chemotherapy], with a taxane rechallenge [is] reasonable given [the] long time since completion of [adjuvant taxane].”

    When asked if she agreed with his reasoning behind using taxane in the first-line setting and sacituzumab govitecan in the second-line, Rugo mentioned the phase 3 ASCENT trial (NCT02574455), which had final data read out at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting, supported this thought process She mentions that this trial then led to the approval of sacituzumab govitecan in the second-line setting for patients with TNBC.3,4

    Another study that was presented at ASCO and, according to Tarantino, showed impressive results was the phase 3 DESTINY-Breast04 trial (NCT03734029) which analyzed fam-trastuzumab deruxtecan-nkxi (Enhertu) in patients with HER2-low breast cancer.5

    In response to data from the DESTINY-Breast04 trial that Tarantino presented, Rugo said, “Really incredible data from DB04 for HR+ and encouraging in TNBC; just [important] to remember that [there were] only 58 pts so 18 in the control arm. And only 1/3 of TNBC [cases] are HER2 low.”

    Rugo also mentioned the ongoing phase 3 ASCENT-03 trial (NCT05382299) examining sacituzumab govitecan vs physician’s choice therapy in previously untreated metastatic TNBC. There is also the phase 3 ASCENT-04 trial (NCT05382286) assessing sacituzumab govitecan plus pembrolizumab vs physician’s choice plus pembrolizumab previously untreated, locally advanced inoperable or metastatic TNBC. Both of these trials utilized sacituzumab govitecan as second-line treatment.

    Tarantino and Rugo also touched on trials involving ADCs such as the phase 1/2 BEGONIA trial (NCT03742102), assessing durvalumab (Imfinzi), capivasertib, oleclumab, paclitaxel, trastuzumab deruxtecan, and datopotamab deruxtecan for patients with metastatic TNBC.6 To better support the data presented with BEGONIA, Tarantino posted a graphic detailing the change from baseline target lesion size and the change from baseline of the number of target lesions over time.

    When asked how they would treat a patient if progression occurred 3 months after initial treatment with first-line therapy, Rugo responded, “Good question, and tragic situation; in this case, we treat as if we are second line, so [we] would use sacituzumab govitecan first-line. At least that is my approach. @PTarantinoMD?If PD-L1 positive how would you treat?”

    Tarantino noted that if a patient is PD-L1 positive, it is worth it to combine first-line pembrolizumab plus chemotherapy. He referenced the phase 3 KEYNOTE-355 trial (NCT02819518) as an example of when to use this treatment combination.7

    Rugo agreed with Tarantino’s recommended course of action, but questioned if the patient was on single arm pembrolizumab at the time of progression, what should be the standard of care? Tarantino noted this was a hard question but said that he would be inclined to administer treatment as though the patient was in the second line, moving to an ADC.

    He then inquired if the patient had a BRCA mutation, would it change the choice of treatment.

    Rugo responded with results from the phase 3 OlympiAD trial (NCT02000622) that focused on the use of olaparib in patients with a BRCA mutation.

    Survival was also improved in the phase 3 EMBRACA trial (NCT01945775), assessing talazoparib in patients with advanced breast cancer who had a germline BRCA mutation.

    In closing, Rugo said she is interested in seeing outcomes with the use of maintenance PARP inhibitors after response is achieved, specifically those with BRCA mutations. Tarantino responded that PARP maintenance is a very interesting strategy and could even have use in other populations outside of those with BRCA mutations.

    To view the full Tweet Chat, visit, https://bit.ly/3XKj1bk

    References

    1. Schmid P, Cortes J, Pusztai L, et al. Pembrolizumab for early triple-negative breast cancer. N Engl J Med. 2020;382(9):810-821. doi:10.1056/NEJMoa1910549
    2. Loibl S, Schneeweiss A, Huober J, et al. Neoadjuvant durvalumab improves survival in early triple-negative breast cancer independent of pathological complete response. Ann Oncol. 2022;33(11):1149-1158. doi:10.1016/j.annonc.2022.07.1940
    3. Final data from phase 3 ASCENT study demonstrates Trodelvy extends overall survival over chemotherapy in second-line metastatic TNBC. News release. Gilead. June 6, 2022. Accessed January 27, 2022. https://bit.ly/40aDYh8
    4. FDA grants regular approval to sacituzumab govitecan for triple-negative breast cancer. News release. FDA. April 7, 2021. Accessed January 27, 2023. https://bit.ly/3Hae98x
    5. Modi S, Jacot W, Yamashita T, et al. Trastuzumab deruxtecan in previously treated HER2-low advanced breast cancer. N Engl J Med. 2022; 387(1):9-20. doi:10.1056/NEJMoa2203690
    6. Loibl S, Schneeweiss A, Huober J, et al. Neoadjuvant durvalumab improves survival in early triple-negative breast cancer independent of pathological complete response. Ann Oncol. 2022;33(11):1149-1158. doi:10.1016/j.annonc.2022.07.1940
    7. Cortes J, Rugo HS, Cescon DW, et al. Pembrolizumab plus chemotherapy in advanced triple-negative breast cancer. N Engl J Med. 2022;387(3):217-226. doi:10.1056/NEJMoa2202809
  • It’s important to know misconceptions shrouding cancer treatment | Lifestyle Health

    It’s important to know misconceptions shrouding cancer treatment | Lifestyle Health

    There are many misconceptions bordering cancer treatment in Kerala. These are not wrong notions persisting in Kerala alone, but the total of India. Without doubt, the misconceptions are engendered by ignorance and outcome in concern psychosis. This procedure has been section historical and partly triggered by the unfold of half-baked truths or erroneous info. Right here is a record of this kind of wrong principles anyone connected with the treatment of cancer ought to be informed of:

    Most cancers is a demise sentence:

    Numerous persons consider that a cancer prognosis is a loss of life sentence, but with improvements in health care engineering and early detection, lots of sorts of most cancers can be dealt with and treated. The simple fact is cancer is a mixed bag and the prognosis and cure solutions fluctuate dependent on the internet site of the cancer and its stage at presentation. The previously it is identified the greater the treatment amount and hence its important to handle any considerations with a experienced clinical professional

    Different drugs is far better:

    Some persons think that alternate medications are extra efficient than typical most cancers treatment plans like chemotherapy or radiation therapy. Even so, there is confined scientific evidence to assist these promises. Some men and women think that cancer solutions like chemotherapy or radiation treatment cause extra damage than good. These conclusions are based on anecdotal tales or untrustworthy net blogs and web-sites that could have vested financial interests in peddling alternate types of treatment plans to even more their passions. Nonetheless, chemotherapy and radiation therapy have proven to be productive in treating cancer and saving lives and are evidence based.

    Most cancers treatment method is costly:

    Whilst some most cancers remedies can be costly, there are numerous economical choices offered, which includes governing administration-operate hospitals and insurance coverage protection. As well being consciousness increases in society, the coverage protection uptake also would be envisioned to enhance which would simplicity the fiscal stress for the afflicted individual.

    Most cancers is prompted by a one variable:

    Lots of folks think that most cancers is prompted by a person precise factor, such as unhealthy way of life practices or publicity to harmful substances. In reality, cancer is a advanced condition that is induced by a mix of genetic and environmental variables. Most cancers development is a elaborate interaction amongst the many environmental factors or extrinsic elements and genetic elements or intrinsic things. Many of the environmental or extrinsic components are modifiable in other words we can act on them to lower our hazards these kinds of as quitting smoking cigarettes, preserving a healthier bodyweight, averting or decreasing liquor usage, decreasing the ingestion of processed meat etcetera.

    Cancer is contagious

    Even though some cancers can be brought on by viruses and bacteria, cancers on their own are not contagious and can’t be distribute from 1 man or woman to a different by near speak to. Cancer sufferers will need compassion and guidance to assistance them get by way of complicated cases and the last matter they will need is isolation. It is important to teach oneself and find correct details from credible sources to dispel these misconceptions and make certain that 1 gets the very best achievable cure.

    (Dr Dhanasekaran VK is Advisor. Radiation Oncology, KIMSHEALTH Cancer Centre, Thiruvananthapuram)